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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004066naa a2200517 4500
001oai:DiVA.org:uu-368156
003SwePub
008181204s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:139389828
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681562 URI
0247 a https://doi.org/10.1158/0008-5472.CAN-18-05022 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1393898282 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gaudet, Mia M4 aut
2451 0a Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype.
264 1c 2018
338 a print2 rdacarrier
520 a Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differences in reproductive factors, but associations with other risk factors are inconsistent. To clarify etiologic heterogeneity, we pooled data from nine cohort studies. Multivariable, joint Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI) for molecular subtypes. Of 606,025 women, 11,741 invasive breast cancers with complete tissue markers developed during follow-up: 8,700 luminal A–like (ER+ or PR+/HER2−), 1,368 luminal B–like (ER+ or PR+/HER2+), 521 HER2-enriched (ER−/PR−/HER2+), and 1,152 triple-negative (ER−/PR−/HER2−) disease. Ever parous compared with never was associated with lower risk of luminal A–like (HR, 0.78; 95% CI, 0.73–0.83) and luminal B–like (HR, 0.74; 95% CI, 0.64–0.87) as well as a higher risk of triple-negative disease (HR, 1.23; 95% CI, 1.02–1.50; P value for overall tumor heterogeneity < 0.001). Direct associations with luminal-like, but not HER2-enriched or triple-negative, tumors were found for age at first birth, years between menarche and first birth, and age at menopause (P value for overall tumor heterogeneity < 0.001). Age-specific associations with baseline body mass index differed for risk of luminal A–like and triple-negative breast cancer (P value for tumor heterogeneity = 0.02). These results provide the strongest evidence for etiologic heterogeneity of breast cancer to date from prospective studies.Significance: These findings comprise the largest study of prospective data to date and contribute to the accumulating evidence that etiological heterogeneity exists in breast carcinogenesis. Cancer Res; 78(20); 6011–21. ©2018 AACR..
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Gierach, Gretchen L4 aut
7001 a Carter, Brian D4 aut
7001 a Luo, Juhua4 aut
7001 a Milne, Roger L4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Giles, Graham G4 aut
7001 a Tamimi, Rulla M4 aut
7001 a Eliassen, A Heather4 aut
7001 a Rosner, Bernard4 aut
7001 a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516
7001 a Adami, Hans-Olovu Karolinska Institutet4 aut
7001 a Margolis, Karen L4 aut
7001 a Gapstur, Susan M4 aut
7001 a Garcia-Closas, Montserrat4 aut
7001 a Brinton, Louise A4 aut
7102 a Karolinska Institutetb Ortopedi4 org
7730 t Cancer Researchg 78:20, s. 6011-6021q 78:20<6011-6021x 0008-5472x 1538-7445
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368156
8564 8u https://doi.org/10.1158/0008-5472.CAN-18-0502
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139389828

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