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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004386naa a2200481 4500
001oai:DiVA.org:uu-369941
003SwePub
008181218s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3699412 URI
0247 a https://doi.org/10.1002/cpt.11832 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Guo, Yingyingu Eli Lilly & Co, Lilly Corp Ctr, Invest Drug Disposit, Indianapolis, IN 46285 USA4 aut
2451 0a Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
264 c 2018-09-12
264 1b John Wiley & Sons,c 2018
338 a print2 rdacarrier
520 a This white paper examines recent progress, applications, and challenges in predicting unbound and total tissue and intra/subcellular drug concentrations using in vitro and preclinical models, imaging techniques, and physiologically based pharmacokinetic (PBPK) modeling. Published examples, regulatory submissions, and case studies illustrate the application of different types of data in drug development to support modeling and decision making for compounds with transporter-mediated disposition, and likely disconnects between tissue and systemic drug exposure. The goals of this article are to illustrate current best practices and outline practical strategies for selecting appropriate in vitro and in vivo experimental methods to estimate or predict tissue and plasma concentrations, and to use these data in the application of PBPK modeling for human pharmacokinetic (PK), efficacy, and safety assessment in drug development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
7001 a Chu, Xiaoyanu Merck & Co Inc, Depat Pharmacokinet Pharmacodynam & Drug Metab, Kenilworth, NJ USA4 aut
7001 a Parrott, Neil J.u F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharmaceut Sci Pharmaceut Res & Early Dev, Basel, Switzerland4 aut
7001 a Brouwer, Kim L. R.u Univ N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27515 USA4 aut
7001 a Hsu, Vickyu US FDA, Off Clin Pharmacol, Off Translat Sci, Ctr Drug Evaluat & Res, Silver Spring, MD USA4 aut
7001 a Nagar, Swatiu Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19122 USA4 aut
7001 a Matsson, Pär,d 1978-u Uppsala universitet,Institutionen för farmaci4 aut0 (Swepub:uu)pamat517
7001 a Sharma, Pradeepu AstraZeneca R&D, IMED Biotech Unit, Safety & ADME Translat Sci Drug Safety & Metab, Cambridge, England4 aut
7001 a Snoeys, Janu Janssen R&D, Dept Pharmacokinet Dynam & Metab, Beerse, Belgium4 aut
7001 a Sugiyama, Yuichiu RIKEN, Res Cluster Innovat, RIKEN Innovat Ctr, Sugiyama Lab, Yokohama, Kanagawa, Japan4 aut
7001 a Tatosian, Danielu Merck & Co Inc, Depat Pharmacokinet Pharmacodynam & Drug Metab, Kenilworth, NJ USA4 aut
7001 a Unadkat, Jashvant D.u Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA4 aut
7001 a Huang, Shiew-Meiu US FDA, Off Clin Pharmacol, Off Translat Sci, Ctr Drug Evaluat & Res, Silver Spring, MD USA4 aut
7001 a Galetin, Aleksandrau Univ Manchester, Sch Hlth Sci, Ctr Appl Pharmacokinet Res, Manchester, Lancs, England4 aut
7102 a Eli Lilly & Co, Lilly Corp Ctr, Invest Drug Disposit, Indianapolis, IN 46285 USAb Merck & Co Inc, Depat Pharmacokinet Pharmacodynam & Drug Metab, Kenilworth, NJ USA4 org
7730 t Clinical Pharmacology and Therapeuticsd : John Wiley & Sonsg 104:5, s. 865-889q 104:5<865-889x 0009-9236x 1532-6535
8564 u https://europepmc.org/articles/pmc6197917?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369941
8564 8u https://doi.org/10.1002/cpt.1183

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