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Sökning: onr:"swepub:oai:DiVA.org:uu-381764" > PET/MRI of glucose ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003906naa a2200409 4500
001oai:DiVA.org:uu-381764
003SwePub
008190415s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3817642 URI
0247 a https://doi.org/10.1038/s41598-021-87768-w2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lundström, Elinu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)ellun086
2451 0a PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
264 c 2021-07-22
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
500 a Title in dissertation list of papers: PET/MRI of glucose uptake, lipid content and perfusion in human brown adipose tissue.
520 a This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (V-A) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and V-A were quantified with dynamic [O-15]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [F-18]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBAT(HI), by MRglu>11 mu mol/100 cm(3)/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (rho <=- 0.87). After 3 h of cold, sBAT-FF decreased (- 2.13 percentage points) but tended to normalize during reheating although sBAT(HI)-FF remained low. sBAT-perfusion and sBAT-V-A increased during cold exposure (perfusion:+5.2 ml/100 cm(3)/min, V-A:+4.0 ml/100 cm(3)). sBAT-perfusion remained elevated and sBAT-V-A normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and V-A, on the changes in FF observed during cold exposure, could not be ruled out.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Andersson, Jonathanu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jonan358
7001 a Engström, Mathiasu GE Healthcare4 aut
7001 a Lubberink, Marku Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.4 aut0 (Swepub:uu)marklubb
7001 a Strand, Robin,d 1978-u Uppsala universitet,Avdelningen för visuell information och interaktion,Radiologi4 aut0 (Swepub:uu)rostr275
7001 a Ahlström, Håkan,d 1953-u Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.4 aut0 (Swepub:uu)hakanahl
7001 a Kullberg, Joel,d 1979-u Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.4 aut0 (Swepub:uu)jokul377
7102 a Uppsala universitetb Radiologi4 org
7730 t Scientific Reportsd : Springer Natureg 11q 11x 2045-2322
8564 u https://doi.org/10.1038/s41598-021-87768-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1305166/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-021-87768-w.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381764
8564 8u https://doi.org/10.1038/s41598-021-87768-w

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