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FältnamnIndikatorerMetadata
00008871naa a2200817 4500
001oai:DiVA.org:uu-390915
003SwePub
008190815s2019 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:f6d3e570-d49e-4af5-ad21-ad4f26e42c5a
009oai:prod.swepub.kib.ki.se:141276750
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3909152 URI
0247 a https://doi.org/10.1002/mnfr.2018014052 DOI
0247 a https://lup.lub.lu.se/record/f6d3e570-d49e-4af5-ad21-ad4f26e42c5a2 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412767502 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Myhrstad, Mari C. W.u Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norway,Oslo Metropolitan University,University of Eastern Finland4 aut
2451 0a Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
264 c 2019-04-18
264 1b John Wiley & Sons,c 2019
338 a print2 rdacarrier
520 a Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-kappa B, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a gene-expression
653 a healthy Nordic diet
653 a metabolic syndrome
653 a peripheral blood mononuclear cells
653 a transcriptome
653 a gene-expression
653 a healthy Nordic diet
653 a metabolic syndrome
653 a peripheral blood mononuclear cells
653 a transcriptome
7001 a de Mello, Vanessa D.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland4 aut
7001 a Dahlman, Ingridu Karolinska Institutet4 aut
7001 a Kolehmainen, Marjukkau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland4 aut
7001 a Paananen, Jussiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland4 aut
7001 a Rundblad, Amandau Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway,University of Oslo4 aut
7001 a Carlberg, Carstenu Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland4 aut
7001 a Olstad, Ole Kristofferu Oslo Univ Hosp, Dept Med Biochem, N-0424 Oslo, Norway,Oslo university hospital4 aut
7001 a Pihlajamaki, Jussiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland,Kuopio University Hospital,University of Eastern Finland4 aut
7001 a Holven, Kirsten B.u Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway;Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Norwegian Natl Advisory Unit Familial Hypercholes, N-0424 Oslo, Norway,University of Oslo,Oslo university hospital4 aut
7001 a Hermansen, Kjeldu Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8200 Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Dragsted, Lars O.u Univ Copenhagen, Dept Nutr Exercise & Sports, Fac Sci, DK-2200 Copenhagen N, Denmark,University of Copenhagen4 aut
7001 a Gunnarsdottir, Ingibjoergu Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland,National University Hospital of Iceland4 aut
7001 a Cloetens, Lieselotteu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tbio-lce
7001 a Storm, Matilda Ulmiusu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)kcx-mui
7001 a Åkesson, Björnu Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital4 aut0 (Swepub:lu)kc-bak
7001 a Rosqvist, Fredrik,d 1985-u Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)frero353
7001 a Hukkanen, Janneu Univ Oulu, Dept Internal Med, Oulu 90014, Finland;Univ Oulu, Bioctr Oulu, Oulu 90014, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu 90014, Finland,University of Oulu,Oulu University Hospital4 aut
7001 a Herzig, Karl-Heinzu Univ Oulu, MRC, Inst Biomed, Oulu 90014, Finland;Univ Oulu, MRC, Bioctr Oulu, Oulu 90014, Finland;Univ Hosp, Oulu 90014, Finland;Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-1061701 Poznan, Poland,Oulu University Hospital,Poznan University of Medical Sciences,University of Oulu4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
7001 a Thorsdottir, Ingau Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland,National University Hospital of Iceland4 aut
7001 a Poutanen, Kaisa S.u Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;VTT Tech Res Ctr Finland, Espoo 02044, Finland,University of Eastern Finland,VTT Technical Research Center of Finland, Espoo4 aut
7001 a Savolainen, Markku J.u Univ Oulu, Dept Internal Med, Oulu 90014, Finland;Univ Oulu, Bioctr Oulu, Oulu 90014, Finland;Oulu Univ Hosp, Med Res Ctr, Oulu 90014, Finland,University of Oulu,Oulu University Hospital4 aut
7001 a Schwab, Ursulau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland;Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland,University of Eastern Finland,Kuopio University Hospital4 aut
7001 a Arner, Peteru Karolinska Institutet4 aut
7001 a Uusitupa, Mattiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland,University of Eastern Finland4 aut
7001 a Ulven, Stine M.u Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway,University of Oslo4 aut
7102 a Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norwayb Oslo Metropolitan University4 org
7730 t Molecular Nutrition & Food Researchd : John Wiley & Sonsg 63:13q 63:13x 1613-4125x 1613-4133
8564 u https://www.duo.uio.no/bitstream/10852/76426/1/Myhrstad%2bet%2bal.pdf
8564 u http://dx.doi.org/10.1002/mnfr.201801405y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390915
8564 8u https://doi.org/10.1002/mnfr.201801405
8564 8u https://lup.lub.lu.se/record/f6d3e570-d49e-4af5-ad21-ad4f26e42c5a
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141276750

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