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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05007naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-395017 | |
| 003 | SwePub | |
| 008 | 191011s2018 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:138679389 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3950172 URI |
| 024 | 7 | a https://doi.org/10.1007/s00167-017-4621-82 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1386793892 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Alim, Md Abdulu Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:uu)abdal689 |
| 245 | 1 0 | a Achilles tendon rupture healing is enhanced by intermittent pneumatic compression upregulating collagen type I synthesis |
| 264 | c 2017-07-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a PURPOSE AND HYPOTHESIS: Adjuvant intermittent pneumatic compression (IPC) during leg immobilization following Achilles tendon rupture (ATR) has been shown to reduce the risk of deep venous thrombosis. The purpose of this study was to investigate whether IPC can also promote tendon healing.METHODS: One hundred and fifty patients with surgical repair of acute ATR were post-operatively leg immobilized and prospectively randomized. Patients were allocated for 2 weeks of either adjuvant IPC treatment (n = 74) or treatment-as-usual (n = 74) in a plaster cast without IPC. The IPC group received 6 h daily bilateral calf IPC applied under an orthosis on the injured side. At 2 weeks post-operatively, tendon healing was assessed using microdialysis followed by enzymatic quantification of tendon callus production, procollagen type I (PINP) and type III (PIIINP) N-terminal propeptide, and total protein content. 14 IPC and 19 cast patients (control group) consented to undergo microdialysis. During weeks 3-6, all subjects were leg-immobilized in an orthosis without IPC. At 3 and 12 months, patient-reported outcome was assessed using reliable questionnaires (ATRS and EQ-5D). At 12 months, functional outcome was measured using the validated heel-rise test.RESULTS: At 2 weeks post-rupture, the IPC-treated patients exhibited 69% higher levels of PINP in the ruptured Achilles tendon (AT) compared to the control group (p = 0.001). Interestingly, the IPC-treated contralateral, intact AT also demonstrated 49% higher concentrations of PINP compared to the non-treated intact AT of the plaster cast group (p = 0.002). There were no adverse events observed associated with IPC. At 3 and 12 months, no significant (n.s.) differences between the two treatments were observed using patient-reported and functional outcome measures.CONCLUSIONS: Adjuvant IPC during limb immobilization in patients with ATR seems to effectively enhance the early healing response by upregulation of collagen type I synthesis, without any adverse effects. Whether prolonged IPC application during the whole immobilization period can also lead to improved long-term clinical healing response should be further investigated. The healing process during leg immobilization in patients with Achilles tendon rupture can be improved through adjuvant IPC therapy, which additionally prevents deep venous thrombosis.LEVEL OF EVIDENCE: Randomized controlled trial, Level I. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a Achilles tendon rupture | |
| 653 | a Intermittent pneumatic compression devices | |
| 653 | a Microdialysis | |
| 653 | a Procollagen | |
| 653 | a Regeneration | |
| 700 | 1 | a Domeij-Arverud, Ericau Karolinska Institutet4 aut |
| 700 | 1 | a Nilsson, Gunnaru Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden4 aut |
| 700 | 1 | a Edman, Gunnaru Karolinska Institutet4 aut |
| 700 | 1 | a Ackermann, Paul Wu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Integrative Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden4 org |
| 773 | 0 | t Knee Surgery, Sports Traumatology, Arthroscopyd : Springer Science and Business Media LLCg 26:7, s. 2021-2029q 26:7<2021-2029x 0942-2056x 1433-7347 |
| 856 | 4 | u https://doi.org/10.1007/s00167-017-4621-8y Fulltext |
| 856 | 4 | u https://link.springer.com/article/10.1007%2Fs00167-017-4621-8y Publisher page |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs00167-017-4621-8.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-395017 |
| 856 | 4 8 | u https://doi.org/10.1007/s00167-017-4621-8 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138679389 |
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