Augmenting inpatient treatment for post-traumatic stress disorder with a computerised cognitive bias modification procedure targeting appraisals (CBM-App): protocol for a randomised controlled trial

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Woud, Marcella L.Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany (author)

Augmenting inpatient treatment for post-traumatic stress disorder with a computerised cognitive bias modification procedure targeting appraisals (CBM-App) : protocol for a randomised controlled trial

Article/chapterEnglish2018

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2018-06-30
BMJ PUBLISHING GROUP,2018
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LIBRIS-ID:oai:DiVA.org:uu-405279
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-405279URI
https://doi.org/10.1136/bmjopen-2017-019964DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139047839URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Introduction Influential theories of post-traumatic stress disorder (PTSD) suggest that dysfunctional appraisals of trauma play a key role in the maintenance of symptoms, and this suggestion is increasingly supported by research. Experimental studies have indicated that a simple computerised cognitive training procedure, here termed cognitive bias modification-appraisals (CBM-App), can modify trauma-relevant appraisals and reduce analogue trauma symptoms among healthy volunteers. This suggests the possibility that CBM-App could improve outcomes in PTSD via targeting the key process of dysfunctional appraisals, for example, if applied as an adjunct to treatment. Methods and analysis The study is a randomised controlled trial with two parallel arms. It is planned to randomise 80 patients admitted for treatment for PTSD to an inpatient treatment clinic to complete either sessions of CBM-App or a sham-training control condition, the peripheral vision task. Both interventions comprise eight sessions scheduled over a 2-week period and are completed in addition to the standard treatment programme in the clinic. Outcome assessment occurs pretraining, after 1 week of training, post-training, at discharge from the inpatient clinic and 6 weeks and 3 months postdischarge. The primary outcome is dysfunctional trauma-relevant appraisals at post-training, measured using a scenario completion task. Secondary outcomes include symptom measures and hair cortisol. Outcome analyses will be primarily via mixed linear models and conducted with both intention to treat and per protocol samples. Ethics and dissemination The trial has been approved by the Ethics Committee for the Faculty of Psychology, Ruhr-Universitat Bochum (approval no 204) and the Ethics Committee for the Faculty of Medicine, Ruhr-Universitat Bochum (approval no 15-5477). Results will be published in peer-reviewed journals and will inform future clinical and experimental studies into targeting maladaptive appraisals for the reduction of PTSD symptoms.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Blackwell, Simon E.Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany (author)
Cwik, Jan C.Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany (author)
Margraf, JuergenRuhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany (author)
Holmes, Emily A.Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden(Swepub:uu)emiho252 (author)
Steudte-Schmiedgen, SusannTech Univ Dresden, Dept Psychol, Dresden, Germany;Tech Univ Dresden, Dept Psychotherapy & Psychosomat Med, Dresden, Germany (author)
Herpertz, StephanRuhr Univ Bochum, LWL Univ Hosp, Dept Psychosomat Med & Psychotherapy, Bochum, Germany (author)
Kessler, HenrikRuhr Univ Bochum, LWL Univ Hosp, Dept Psychosomat Med & Psychotherapy, Bochum, Germany (author)
Karolinska InstitutetRuhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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