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Sökning: onr:"swepub:oai:DiVA.org:uu-405280" > Investigating d-cyc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004089naa a2200481 4500
001oai:DiVA.org:uu-405280
003SwePub
008200228s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:138258691
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4052802 URI
0247 a https://doi.org/10.1177/02698811187546792 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1382586912 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Woud, Marcella L.u Ruhr Univ Bochum, Dept Psychol, Bochum, Germany4 aut
2451 0a Investigating d-cycloserine as a potential pharmacological enhancer of an emotional bias learning procedure
264 c 2018-02-15
264 1b SAGE PUBLICATIONS LTD,c 2018
338 a print2 rdacarrier
520 a The partial N-methyl-D-aspartate receptor agonist d-cycloserine may enhance psychological therapies. However, its exact mechanism of action is still being investigated. Cognitive bias modification techniques allow isolation of cognitive processes and thus investigation of how they may be affected by d-cycloserine. We used a cognitive bias modification paradigm targeting appraisals of a stressful event, Cognitive Bias Modification-Appraisal, to investigate whether d-cycloserine enhanced the modification of appraisal, and whether it caused greater reduction in indices of psychopathology. Participants received either 250 mg of d-cycloserine (n=19) or placebo (n=19). As a stressor task, participants recalled a negative life event, followed by positive Cognitive Bias Modification-Appraisal training. Before and after Cognitive Bias Modification-Appraisal, appraisals and indices of psychopathology related to the stressor were assessed. Cognitive Bias Modification-Appraisal successfully modified appraisals, but d-cycloserine did not affect appraisals post-training. There were no post-training group differences in frequency of intrusions. Interestingly, d-cycloserine led to a greater reduction in distress and impact on state mood from recalling the event, and lower distress post-training was associated with fewer intrusions. Therefore, d-cycloserine may affect emotional reactivity to recalling a negative event when combined with induction of a positive appraisal style, but via a mechanism other than enhanced learning of the appraisal style.
650 7a SAMHÄLLSVETENSKAPx Psykologix Tillämpad psykologi0 (SwePub)501022 hsv//swe
650 7a SOCIAL SCIENCESx Psychologyx Applied Psychology0 (SwePub)501022 hsv//eng
653 a d-Cycloserine
653 a emotional learning
653 a appraisal
653 a emotional reactivity
653 a cognitive bias modification
7001 a Blackwell, Simon E.u Ruhr Univ Bochum, Dept Psychol, Bochum, Germany4 aut
7001 a Steudte-Schmiedgen, Susannu Tech Univ Dresden, Dept Psychol, Dresden, Germany4 aut
7001 a Browning, Michaelu Univ Oxford, Dept Psychiat, Oxford, England4 aut
7001 a Holmes, Emily A.u Karolinska Institutet4 aut0 (Swepub:uu)emiho252
7001 a Harmer, Catherine J.u Univ Oxford, Dept Psychiat, Oxford, England4 aut
7001 a Margraf, Juergenu Ruhr Univ Bochum, Dept Psychol, Bochum, Germany4 aut
7001 a Reinecke, Andreau Univ Oxford, Dept Psychiat, Oxford, England4 aut
7102 a Ruhr Univ Bochum, Dept Psychol, Bochum, Germanyb Tech Univ Dresden, Dept Psychol, Dresden, Germany4 org
7730 t Journal of Psychopharmacologyd : SAGE PUBLICATIONS LTDg 32:5, s. 569-577q 32:5<569-577x 0269-8811x 1461-7285
8564 u https://ora.ox.ac.uk/objects/uuid:9ecc9487-8710-408c-bd61-0d6f84c9c5c8/download_file?safe_filename=MS%2BWoud%2B20.10.pdf&file_format=application%2Fpdf&type_of_work=Journal+article
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-405280
8564 8u https://doi.org/10.1177/0269881118754679
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:138258691

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