Sökning: onr:"swepub:oai:DiVA.org:uu-4057" > Towards the Develop...
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000 | 03392nam a2200469 4500 | |
001 | oai:DiVA.org:uu-4057 | |
003 | SwePub | |
008 | 040311s2004 | |||||||||||000 ||eng| | |
020 | a 9155458971q print | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-40572 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a dok2 swepub-publicationtype |
100 | 1 | a Erdélyi, Máté,d 1975-u Uppsala universitet,Avdelningen för organisk kemi4 aut |
245 | 1 0 | a Towards the Development of Photoswitchable β-Hairpin Mimetics |
264 | 1 | a Uppsala :b Acta Universitatis Upsaliensis,c 2004 |
300 | a 90 s. | |
338 | a electronic2 rdacarrier | |
490 | 0 | a Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology,x 1104-232X ;v 950 |
520 | a Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. This thesis addresses the design, synthesis and conformational analysis of photoswitchable β-hairpin mimetics.The developmental work included the establishment of an improved procedure for cross coupling of aryl halides with terminal alkynes. Microwave mediated Sonogashira couplings in closed vessels were optimized under homogeneous and solid-phase conditions furnishing excellent yields for a large variety of substrates within 5 – 25 minutes. In addition, microwave heating was shown not to have any non-conventional effect on the reaction rate.Furthermore, the most important factors affecting β-hairpin stability were evaluated. Studies of tetrapeptide and decapeptide analogues revealed the essential role of the β-turn in initiation of hairpin folding. Moreover, hydrogen bonding was shown to be the main interchain stabilizing force, whereas hydrophobic interactions were found to be relatively weak. Nevertheless, hydrophobic packing appears to provide an important contribution to the thermodynamic stability of β-hairpins.Photoswitchable peptidomimetics were prepared by incorporation of various stilbene moieties into tetra- and decapeptides. Synthesis, photochemical isomerisation and spectroscopic conformational analysis of the compounds were performed. | |
650 | 7 | a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng |
653 | a Organic chemistry | |
653 | a β-hairpin | |
653 | a peptidomimetics | |
653 | a Sonogashira | |
653 | a NMR | |
653 | a photochemistry | |
653 | a microwave | |
653 | a peptide | |
653 | a palladium | |
653 | a Organisk kemi | |
653 | a Organic chemistry | |
653 | a Organisk kemi | |
700 | 1 | a Gogoll, Adolf4 ths |
700 | 1 | a Karlén, Anders4 ths |
700 | 1 | a Robinson, John A.,c Professoru Institute of Organic Chemistry, Zürich4 opn |
710 | 2 | a Uppsala universitetb Avdelningen för organisk kemi4 org |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:164205/FULLTEXT01.pdfx primaryx Raw objecty fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4057 |
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