Sökning: onr:"swepub:oai:DiVA.org:uu-406215" >
alpha-Synuclein str...
alpha-Synuclein strains target distinct brain regions and cell types
-
- Lau, Angus (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Biochem, Toronto, ON, Canada
-
- So, Raphaella W. L. (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Biochem, Toronto, ON, Canada
-
- Lau, Heather H. C. (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Biochem, Toronto, ON, Canada
-
visa fler...
-
- Sang, Jason C. (författare)
- Univ Cambridge, Dept Chem, Cambridge, England
-
- Ruiz-Riquelme, Alejandro (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany
-
- Fleck, Shelaine C. (författare)
- Univ Alberta, Ctr Prions & Prot Folding Dis, Edmonton, AB, Canada;Univ Alberta, Dept Biochem, Edmonton, AB, Canada
-
- Stuart, Erica (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
-
- Menon, Sindhu (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
-
- Visanji, Naomi P. (författare)
- Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Ctr, Toronto, ON, Canada;Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada
-
- Meisl, Georg (författare)
- Univ Cambridge, Dept Chem, Cambridge, England
-
- Faidi, Rania (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
-
- Marano, Maria M. (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Med, Toronto, ON, Canada
-
- Schmitt-Ulms, Cian (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
-
- Wang, Zhilan (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
-
- Fraser, Paul E. (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
-
- Tandon, Anurag (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Med, Toronto, ON, Canada
-
- Hyman, Bradley T. (författare)
- Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA USA;Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA;Harvard Med Sch, Neurosci Program, Boston, MA 02115 USA
-
- Wille, Holger (författare)
- Univ Alberta, Ctr Prions & Prot Folding Dis, Edmonton, AB, Canada;Univ Alberta, Dept Biochem, Edmonton, AB, Canada
-
- Ingelsson, Martin (författare)
- Uppsala universitet,Geriatrik
-
- Klenerman, David (författare)
- Univ Cambridge, Dept Chem, Cambridge, England;Univ Cambridge, UK Dementia Res Inst, Cambridge, England
-
- Watts, Joel C. (författare)
- Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada;Univ Toronto, Dept Biochem, Toronto, ON, Canada
-
visa färre...
-
(creator_code:org_t)
- 2019-12-02
- 2020
- Engelska.
-
Ingår i: Nature Neuroscience. - : NATURE PUBLISHING GROUP. - 1097-6256 .- 1546-1726. ; 23, s. 21-31
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The clinical and pathological differences between synucleinopathies such as Parkinson's disease and multiple system atrophy have been postulated to stem from unique strains of alpha-synuclein aggregates, akin to what occurs in prion diseases. Here we demonstrate that inoculation of transgenic mice with different strains of recombinant or brain-derived alpha-synuclein aggregates produces clinically and pathologically distinct diseases. Strain-specific differences were observed in the signs of neurological illness, time to disease onset, morphology of cerebral alpha-synuclein deposits and the conformational properties of the induced aggregates. Moreover, different strains targeted distinct cellular populations and cell types within the brain, recapitulating the selective targeting observed among human synucleinopathies. Strain-specific clinical, pathological and biochemical differences were faithfully maintained after serial passaging, which implies that alpha-synuclein propagates via prion-like conformational templating. Thus, pathogenic alpha-synuclein exhibits key hallmarks of prion strains, which provides evidence that disease heterogeneity among the synucleinopathies is caused by distinct alpha-synuclein strains.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lau, Angus
-
So, Raphaella W. ...
-
Lau, Heather H. ...
-
Sang, Jason C.
-
Ruiz-Riquelme, A ...
-
Fleck, Shelaine ...
-
visa fler...
-
Stuart, Erica
-
Menon, Sindhu
-
Visanji, Naomi P ...
-
Meisl, Georg
-
Faidi, Rania
-
Marano, Maria M.
-
Schmitt-Ulms, Ci ...
-
Wang, Zhilan
-
Fraser, Paul E.
-
Tandon, Anurag
-
Hyman, Bradley T ...
-
Wille, Holger
-
Ingelsson, Marti ...
-
Klenerman, David
-
Watts, Joel C.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Nature Neuroscie ...
- Av lärosätet
-
Uppsala universitet