Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

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Fältnamn	Indikatorer	Metadata
000		12047naa a2201213 4500
001		oai:DiVA.org:uu-412335
003		SwePub
008		200608s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:143636768
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4123352 URI
024	7	a https://doi.org/10.3324/haematol.2019.2207562 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436367682 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lazaryan, Aleksandru H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.4 aut
245	1 0	a Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation :b a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research
264		c 2019-09-26
264	1	b Ferrata Storti Foundation (Haematologica),c 2020
338		a electronic2 rdacarrier
520		a Cytogenetic risk stratification at diagnosis has long been one of the most useful tools to assess prognosis in acute lymphoblastic leukemia (ALL). To examine the prognostic impact of cytogenetic abnormalities on outcomes after allogeneic hematopoietic cell transplantation, we studied 1731 adults with Philadelphia-negative ALL in complete remission who underwent myeloablative or reduced intensity/non-myeloablative conditioning transplant from unrelated or matched sibling donors reported to the Center for International Blood and Marrow Transplant Research. A total of 632 patients had abnormal conventional metaphase cytogenetics. The leukemia-free survival and overall survival rates at 5 years after transplantation in patients with abnormal cytogenetics were 40% and 42%, respectively, which were similar to those in patients with a normal karyotype. Of the previously established cytogenetic risk classifications, modified Medical Research Council-Eastern Cooperative Oncology Group score was the only independent prognosticator of leukemia-free survival (P=0.03). In the multivariable analysis, monosomy 7 predicted post-transplant relapse [hazard ratio (HR)=2.11; 95% confidence interval (95% CI): 1.04-4.27] and treatment failure (HR=1.97; 95% CI: 1.20-3.24). Complex karyotype was prognostic for relapse (HR=1.69; 95% CI: 1.06-2.69), whereas t(8;14) predicted treatment failure (HR=2.85; 95% CI: 1.35-6.02) and overall mortality (HR=3.03; 95% CI: 1.44-6.41). This large study suggested a novel transplant-specific cytogenetic scheme with adverse [monosomy 7, complex karyotype, del(7q), t(8;14), t(11;19), del(7q), tetraploidy/near triploidy], intermediate (normal karyotype and all other abnormalities), and favorable (high hyperdiploidy) risks to prognosticate leukemia-free survival (P=0.02). Although some previously established high-risk Philadelphia-negative cytogenetic abnormalities in ALL can be overcome by transplantation, monosomy 7, complex karyotype, and t(8;14) continue to pose significant risks and yield inferior outcomes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
700	1	a Dolan, Michelleu Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.4 aut
700	1	a Zhang, Mei-Jieu Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut
700	1	a Wang, Hai-Linu Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.4 aut
700	1	a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.4 aut
700	1	a Marks, David, Iu Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.4 aut
700	1	a Bejanyan, Nelliu H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut
700	1	a Copelan, Edwardu Carolinas HealthCare Syst, Atrium Hlth, Levine Canc Inst, Charlotte, NC USA.4 aut
700	1	a Majhail, Navneet S.u Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.4 aut
700	1	a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.4 aut
700	1	a Chao, Nelsonu Duke Univ, Med Ctr, Dept Med, Div Cell Therapy & Hematol, Durham, NC 27710 USA.4 aut
700	1	a Prestidge, Timu Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.4 aut
700	1	a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.4 aut
700	1	a Kebriaei, Partowu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.4 aut
700	1	a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut
700	1	a Hamilton, Bettyu Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.4 aut
700	1	a Hashmi, Shahrukh K.u Mayo Clin, Dept Internal Med, Rochester, MN USA.;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.4 aut
700	1	a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.4 aut
700	1	a Bacher, Ulrikeu Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland.4 aut
700	1	a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut
700	1	a Stiff, Patrick J.u Loyola Univ Med Ctr, Maywood, IL 60153 USA.4 aut
700	1	a McGuirk, Josephu Univ Kansas, Med Ctr, Westwood, KS USA.4 aut
700	1	a Aldoss, Ibrahimu City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA.4 aut
700	1	a Beitinjaneh, Amer M.u Univ Miami, Miami, FL USA.4 aut
700	1	a Muffly, Loriu Stanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.4 aut
700	1	a Vij, Raviu Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.4 aut
700	1	a Olsson, Richardu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden4 aut0 (Swepub:uu)riols677
700	1	a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Schultz, Kirk R.u Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.4 aut
700	1	a Aljurf, Mahmoudu King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.4 aut
700	1	a Seftel, Matthewu CancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada.4 aut
700	1	a Savoie, Mary Lynnu Tom Baker Canc Clin, Calgary, AB, Canada.4 aut
700	1	a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut
700	1	a Verdonck, Leo F.u Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.4 aut
700	1	a Cairo, Mitchell S.u New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut
700	1	a Hossain, Nasheedu Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA.4 aut
700	1	a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut
700	1	a Frangoul, Haydar A.u Childrens Hosp TriStar Centennial, Nashville, TN USA.;Sarah Cannon Res Inst, Nashville, TN USA.4 aut
700	1	a Abdel-Azim, Hishamu Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA.4 aut
700	1	a Al Malki, Monzru City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA.4 aut
700	1	a Munker, Reinholdu Louisiana State Univ Hlth Shreveport, Dept Internal Med, Sect Hematol Oncol, Shreveport, LA USA.4 aut
700	1	a Rizzieri, Davidu Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.4 aut
700	1	a Khera, Nanditau Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA.4 aut
700	1	a Nakamura, Ryotarou City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.4 aut
700	1	a Ringden, Olleu Karolinska Institutet4 aut
700	1	a van der Poel, Marjoleinu Acad Ziekenhuis Maastricht, Maastricht, Netherlands.4 aut
700	1	a Murthy, Hemant S.u Mayo Clin Florida, Jacksonville, FL USA.4 aut
700	1	a Liu, Hongtaou Univ Chicago Med, Chicago, IL USA.4 aut
700	1	a Mori, Shahramu Florida Hosp Med Grp, Blood & Marrow Transplant Ctr, Orlando, FL USA.4 aut
700	1	a De Oliveira, Satirou UCLA, Med Ctr, Los Angeles, CA 90024 USA.4 aut
700	1	a Bolanos-Meade, Javieru Sidney Kimmel Comprehens Canc Ctr Johns Hopkins B, Baltimore, MD USA.4 aut
700	1	a Elsawy, Mahmoudu Dalhousie Univ, QE II Hlth Sci Ctr, Halifax, NS, Canada.4 aut
700	1	a Barba, Pereu Hosp Valle De Hebron, Barcelona, Spain.4 aut
700	1	a Nathan, Sunitau Rush Univ, Med Ctr, Chicago, IL 60612 USA.4 aut
700	1	a George, Bijuu Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.4 aut
700	1	a Pawarode, Attapholu Univ Michigan, Dept Internal Med, Div Hematol Oncol, Med Sch,Blood & Marrow Transplantat Program, Ann Arbor, MI USA.4 aut
700	1	a Grunwald, Michaelu Atrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.4 aut
700	1	a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut
700	1	a Wang, Youjinu NCI, Rockville, MD USA.4 aut
700	1	a Assal, Ameru Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USA.4 aut
700	1	a Caro, Paul Castillou UF Hlth Shands Childrens Hosp, Gainesville, FL USA.4 aut
700	1	a Kuwatsuka, Yachiyou Nagoya Univ Hosp, Dept Adv Med, Nagoya, Aichi, Japan.4 aut
700	1	a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.4 aut
700	1	a Ustun, Celalettinu Rush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA.4 aut
700	1	a Politikos, Ioannisu Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut
700	1	a Lazarus, Hillard M.u Case Western Reserve Univ, Cleveland, OH 44106 USA.4 aut
700	1	a Saber, Waelu Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.4 aut
700	1	a Sandmaier, Brenda M.u Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut
700	1	a De Lima, Marcosu Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.4 aut
700	1	a Litzow, Marku Mayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA.4 aut
700	1	a Bachanova, Veronikau Univ Minnesota, Med Ctr, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA.4 aut
700	1	a Weisdorf, Danielu Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.4 aut
710	2	a H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.b Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.4 org
773	0	t Haematologicad : Ferrata Storti Foundation (Haematologica)g 105:5, s. 1329-1338q 105:5<1329-1338x 0390-6078x 1592-8721
856	4	u https://doi.org/10.3324/haematol.2019.220756y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1436732/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://haematologica.org/article/download/9388/68438
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412335
856	4 8	u https://doi.org/10.3324/haematol.2019.220756
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143636768

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By the author/editor: Lazaryan, Aleksa ...; Dolan, Michelle; Zhang, Mei-Jie; Wang, Hai-Lin; Kharfan-Dabaja, ...; Marks, David, I; show more...; Bejanyan, Nelli; Copelan, Edward; Majhail, Navneet ...; Waller, Edmund K ...; Chao, Nelson; Prestidge, Tim; Nishihori, Taiga; Kebriaei, Partow; Inamoto, Yoshihi ...; Hamilton, Betty; Hashmi, Shahrukh ...; Kamble, Rammurti ...; Bacher, Ulrike; Hildebrandt, Ger ...; Stiff, Patrick J ...; McGuirk, Joseph; Aldoss, Ibrahim; Beitinjaneh, Ame ...; Muffly, Lori; Vij, Ravi; Olsson, Richard; Byrne, Michael; Schultz, Kirk R.; Aljurf, Mahmoud; Seftel, Matthew; Savoie, Mary Lyn ...; Savani, Bipin N.; Verdonck, Leo F.; Cairo, Mitchell ...; Hossain, Nasheed; Bhatt, Vijaya Ra ...; Frangoul, Haydar ...; Abdel-Azim, Hish ...; Al Malki, Monzr; Munker, Reinhold; Rizzieri, David; Khera, Nandita; Nakamura, Ryotar ...; Ringden, Olle; van der Poel, Ma ...; Murthy, Hemant S ...; Liu, Hongtao; Mori, Shahram; De Oliveira, Sat ...; Bolanos-Meade, J ...; Elsawy, Mahmoud; Barba, Pere; Nathan, Sunita; George, Biju; Pawarode, Attaph ...; Grunwald, Michae ...; Agrawal, Vaibhav; Wang, Youjin; Assal, Amer; Caro, Paul Casti ...; Kuwatsuka, Yachi ...; Seo, Sachiko; Ustun, Celaletti ...; Politikos, Ioann ...; Lazarus, Hillard ...; Saber, Wael; Sandmaier, Brend ...; De Lima, Marcos; Litzow, Mark; Bachanova, Veron ...; Weisdorf, Daniel; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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