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Sökning: onr:"swepub:oai:DiVA.org:uu-419795" > Post-Discharge Blee...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006082naa a2200553 4500
001oai:DiVA.org:uu-419795
003SwePub
008200916s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4197952 URI
0247 a https://doi.org/10.1016/j.jacc.2020.05.0312 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Marquis-Gravel, Guillaumeu Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.4 aut
2451 0a Post-Discharge Bleeding and Mortality Following Acute Coronary Syndromes With or Without PCI
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
520 a BACKGROUND The long-term prognostic impact of post-discharge bleeding in the unique population of patients with acute coronary syndrome (ACS) treated without percutaneous coronary intervention (PCI) remains unexplored.OBJECTIVES The aim of this study was to assess the association between post-discharge bleeding and subsequent mortality after ACS according to index strategy (PCI or no PCI) and to contrast with the association between post-discharge myocardial infarction (MI) and subsequent mortality.METHODS In a harmonized dataset of 4 multicenter randomized trials (APPRAISE-2 [Apixaban for Prevention of Acute Ischemic Events-2], PLATO [Study of Platelet Inhibition and Patient Outcomes], TRACER [Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome], and TRILOGY ACS [Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes]), the association between post-discharge noncoronary artery bypass graft-related GUSTO (Global Use of Strategies to Open Occluded Coronary Arteries) moderate, severe, or life-threatening bleeding (landmark 7 days post-ACS) and subsequent all-cause mortality was evaluated in a time-updated Cox proportional hazards analysis. Interaction with index treatment strategy was assessed. Results were contrasted with risk for mortality following post-discharge MI.RESULTS Among 45,011 participants, 1,133 experienced post-discharge bleeding events (2.6 per 100 patient-years), and 2,149 died during follow-up. The risk for mortality was significantly higher <30 days (adjusted hazard ratio: 15.7; 95% confidence interval: 12.3 to 20.0) and 30 days to 12 months (adjusted hazard ratio: 2.7; 95% confidence interval: 2.1 to 3.4) after bleeding, and this association was consistent in participants treated with or without PCI for their index ACS (p for interaction = 0.240). The time-related association between post-discharge bleeding and mortality was similar to the association between MI and subsequent mortality in participants treated with and without PCI (p for interaction = 0.696).CONCLUSIONS Post-discharge bleeding after ACS is associated with a similar increase in subsequent all-cause mortality in participants treated with or without PCI and has an equivalent prognostic impact as post-discharge MI.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a acute coronary syndrome
653 a bleeding
653 a mortality
653 a percutaneous coronary intervention
653 a randomized trial
7001 a Dalgaard, Frederiku Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.4 aut
7001 a Jones, Aaron D.u Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.4 aut
7001 a Lokhnygina, Yuliyau Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.4 aut
7001 a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Harrington, Robert A.u Stanford Univ, Dept Med, Stanford, CA 94305 USA.4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7001 a Steg, Philippe Gabrielu Univ Paris, AP HP, Paris, France.;INSERM U1148, Paris, France.;Imperial Coll, Royal Brompton Hosp, London, England.4 aut
7001 a Lopes, Renato D.u Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.;Duke Univ, Sch Med, Div Cardiol, Durham, NC 27708 USA.4 aut
7001 a Storey, Robert F.u Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England.4 aut
7001 a Goodman, Shaun G.u Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada.;Univ Toronto, St Michaels Hosp, Toronto, ON, Canada.4 aut
7001 a Mahaffey, Kenneth W.u Stanford Sch Med, Dept Med, Stanford Ctr Clin Res, Palo Alto, CA USA.4 aut
7001 a Tricoci, Pierluigiu CSL Behring, Durham, NC USA.4 aut
7001 a White, Harvey D.u Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.4 aut
7001 a Armstrong, Paul W.u Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada.;Univ Alberta, Div Cardiol, Edmonton, AB, Canada.4 aut
7001 a Ohman, E. Magnusu Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.;Duke Univ, Sch Med, Div Cardiol, Durham, NC 27708 USA.4 aut
7001 a Alexander, John H.u Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.;Duke Univ, Sch Med, Div Cardiol, Durham, NC 27708 USA.4 aut
7001 a Roe, Matthew T.u Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.;Duke Univ, Sch Med, Div Cardiol, Durham, NC 27708 USA.4 aut
7102 a Duke Clin Res Inst, 200 Morris St,Room 7410, Durham, NC 27701 USA.b Kardiologi4 org
7730 t Journal of the American College of Cardiologyd : Elsevier BVg 76:2, s. 162-171q 76:2<162-171x 0735-1097x 1558-3597
8564 u https://doi.org/10.1016/j.jacc.2020.05.031
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419795
8564 8u https://doi.org/10.1016/j.jacc.2020.05.031

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