onr:"swepub:oai:DiVA.org:uu-421050"
Search: onr:"swepub:oai:DiVA.org:uu-421050" > Caesalpinia cristac...
- 1 of 1
- Previous record
- Next record
- To hitlist
Caesalpinia cristacoat extract protects red blood cell from sodium nitrite-induced oxidative stress and exhibits antiplatelet activity
-
- Srinivasa, Chandramma (author)
- Tumkur Univ, Dept Studies & Res Biochem, BH Rd, Tumakuru 572103, India.
-
- Kengaiah, Jayanna (author)
- Tumkur Univ, Dept Studies & Res Biochem, BH Rd, Tumakuru 572103, India.
-
- Nandish, Sharath Kumar M. (author)
- Tumkur Univ, Dept Studies & Res Biochem, BH Rd, Tumakuru 572103, India.
- show more...
- show less...
- Tumkur Univ, Dept Studies & Res Biochem, BH Rd, Tumakuru 572103, India Kuvempu University, Dept Biochem Jnansahydri, Shivamogga, Karnataka, India. (creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2020
- 2020
- English.
- In: Blood Coagulation and Fibrinolysis. - : LIPPINCOTT WILLIAMS & WILKINS. - 0957-5235 .- 1473-5733. ; 31:5, s. 293-302
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- To understand the RBC protecting efficiency and antiplatelet activity of methanolic extract ofCaesalpinia cristacoat (MECCC). RBC-protecting activity of MECCC was evaluated using assays, such as DPPH, level of lipid peroxidation, protein carbonyl content, superoxide dismutase and catalase as a marker of oxidative stress whereas, platelet aggregation inhibition was performed using human platelet-rich plasma (PRP). MECCC showed about 76% of DPPH-scavenging activity, with an IC(50)value of 71.89 mu g/ml. The MECCC reduced the level of lipid peroxidation and protein carboxylation in RBC caused by NaNO(2)in a dose-dependent manner. In addition, MECCC normalized the levels of superoxide dismutase (SOD) and catalase (CAT) in oxidative stress-induced RBC in a dose-dependent manner. This suggested the protective effect of MECCC on RBC against oxidative stress. Furthermore, MECCC also exhibited mild antiplatelet activity by inhibiting both ADP and epinephrine agonists that induced platelet aggregation. The noticed inhibition percentage was found to be 28 and 23%, respectively at the concentration of 150 mu g. Interestingly, MECCC did not hydrolyse the RBC suggesting its nontoxic properties. MECCC possesses protective effect of RBC against NaNO2(10 mmol/l) induce oxidative stress and inhibits platelet aggregation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- antiplatelet
- 1
- 1-diphenyl-2-picrylhydrazyl
- red blood cell
- sodium nitrite
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Blood Coagulation and Fibrinolysis (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Srinivasa, Chand ...
- Kengaiah, Jayann ...
- Nandish, Sharath ...
- Ramachandraiah, ...
- Hanumegowda, Suj ...
- Shivaiah, Ashwin ...
- show more...
- Santhosh, Sebest ...
- Sannaningaiah, D ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Hematology
- Articles in the publication
- Blood Coagulatio ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
