Sökning: onr:"swepub:oai:DiVA.org:uu-423938" > A Grading System fo...
Fältnamn | Indikatorer | Metadata |
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000 | 08259naa a2200913 4500 | |
001 | oai:DiVA.org:uu-423938 | |
003 | SwePub | |
008 | 201109s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4239382 URI |
024 | 7 | a https://doi.org/10.1016/j.jtho.2020.06.0012 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Moreira, Andre L.u New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.4 aut |
245 | 1 0 | a A Grading System for Invasive Pulmonary Adenocarcinoma :b A Proposal From the International Association for the Study of Lung Cancer Pathology Committee |
264 | 1 | b ELSEVIER SCIENCE INC,c 2020 |
338 | a print2 rdacarrier | |
520 | a Introduction: A grading system for pulmonary adenocarcinoma has not been established. The International Association for the Study of Lung Cancer pathology panel evaluated a set of histologic criteria associated with prognosis aimed at establishing a grading system for invasive pulmonary adenocarcinoma. Methods: A multi-institutional study involving multiple cohorts of invasive pulmonary adenocarcinomas was conducted. A cohort of 284 stage I pulmonary adenocarcinomas was used as a training set to identify histologic features associated with patient outcomes (recurrence-free survival [RFS] and overall survival [OS]). Receiver operating characteristic curve analysis was used to select the best model, which was validated (n = 212) and tested (n = 300, including stage I-III) in independent cohorts. Reproducibility of the model was assessed using kappa statistics. Results: The best model (area under the receiver operating characteristic curve [AUC] = 0.749 for RFS and 0.787 for OS) was composed of a combination of predominant plus high-grade histologic pattern with a cutoff of 20% for the latter. The model consists of the following: grade 1, lepidic predominant tumor; grade 2, acinar or papillary predominant tumor, both with no or less than 20% of high-grade patterns; and grade 3, any tumor with 20% or more of high-grade patterns (solid, micropapillary, or complex gland). Similar results were seen in the validation (AUC = 0.732 for RFS and 0.787 for OS) and test cohorts (AUC = 0.690 for RFS and 0.743 for OS), confirming the predictive value of the model. Interobserver reproducibility revealed good agreement (k = 0.617). Conclusions: A grading system based on the predominant and high-grade patterns is practical and prognostic for invasive pulmonary adenocarcinoma. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Adenocarcinoma | |
653 | a Tumor grading | |
653 | a Lung | |
653 | a Model | |
653 | a Prognosis | |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Ocampo, Paolo S. S.u New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.4 aut |
700 | 1 | a Xia, Yuheu New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 aut |
700 | 1 | a Zhong, Huau New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 aut |
700 | 1 | a Russell, Prudence A.u St Vincents Hosp, Dept Pathol, Fitzroy, Vic, Australia.4 aut |
700 | 1 | a Minami, Yukou Ibarakihigashi Natl Hosp, Dept Pathol, Tokai, Ibaraki, Japan.4 aut |
700 | 1 | a Cooper, Wendy A.u Royal Prince Alfred Hosp, Dept Pathol, Camperdown, NSW, Australia.4 aut |
700 | 1 | a Yoshida, Akihikou Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut |
700 | 1 | a Bubendorf, Lukasu Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland.4 aut |
700 | 1 | a Papotti, Maurou Univ Turin, Dept Oncol, Turin, Italy.4 aut |
700 | 1 | a Pelosi, Giuseppeu Univ Milan, Dept Pathol, Milan, Italy.;IRCCS MultiMed, Milan, Italy.4 aut |
700 | 1 | a Lopez-Rios, Fernandou HM Hosp, Pathol Lab Dianas Terapeut, Madrid, Spain.4 aut |
700 | 1 | a Kunitoki, Keikou Harvard TH Chan Sch Publ Hlth, Boston, MA USA.4 aut |
700 | 1 | a Ferrari-Light, Danau New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.4 aut |
700 | 1 | a Sholl, Lynette M.u Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.4 aut |
700 | 1 | a Beasley, Mary Bethu Mt Sinai Hlth Syst, Icahn Sch Med, Dept Pathol, New York, NY USA.4 aut |
700 | 1 | a Borczuk, Alainu Weill Cornell Med, Dept Pathol, New York, NY USA.4 aut |
700 | 1 | a Botling, Johanu Uppsala universitet,Klinisk och experimentell patologi,Johan Botling4 aut0 (Swepub:uu)johanbot |
700 | 1 | a Brambilla, Elisabethu Univ Grenoble Alpes, Dept Anat Pathol & Cytol, Grenoble, France.4 aut |
700 | 1 | a Chen, Gangu Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China.4 aut |
700 | 1 | a Chou, Teh-Yingu Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan.4 aut |
700 | 1 | a Chung, Jin-Haengu Seoul Natl Univ, Dept Pathol, Bundang Hosp, Seoul, South Korea.4 aut |
700 | 1 | a Dacic, Sanjau Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA USA.4 aut |
700 | 1 | a Jain, Deepaliu All India Inst Med Sci, Dept Pathol, New Delhi, India.4 aut |
700 | 1 | a Hirsch, Fred R.u Tisch Canc Inst, Ctr Thorac Oncol, New York, NY USA.4 aut |
700 | 1 | a Hwang, Davidu Sunnybrook Hlth Sci Ctr, Dept Lab Med & Mol Diagnost, Toronto, ON, Canada.4 aut |
700 | 1 | a Lantuejoul, Sylvieu Ctr Leon Berard Unicanc, Dept Pathol, Lyon, France.4 aut |
700 | 1 | a Lin, Dongmeiu Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing, Peoples R China.4 aut |
700 | 1 | a Longshore, John W.u Atrium Hlth, Carolinas Pathol Grp, Charlotte, NC USA.4 aut |
700 | 1 | a Motoi, Norikou Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut |
700 | 1 | a Noguchi, Masayukiu Univ Tsukuba, Dept Pathol, Tsukuba, Ibaraki, Japan.4 aut |
700 | 1 | a Poleri, Claudiau Off Pathol Consultants, Buenos Aires, DF, Argentina.4 aut |
700 | 1 | a Rekhtman, Natashau Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Tsao, Ming-Soundu Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.4 aut |
700 | 1 | a Thunnissen, Eriku Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands.4 aut |
700 | 1 | a Travis, William D.u Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Yatabe, Yasushiu Natl Canc Ctr, Dept Diagnost Pathol, Tokyo, Japan.4 aut |
700 | 1 | a Roden, Anja C.u Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.4 aut |
700 | 1 | a Daigneault, Jillian B.u Int Assoc Study Lung Canc, Aurora, CO USA.4 aut |
700 | 1 | a Wistuba, Ignacio I.u Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA.4 aut |
700 | 1 | a Kerr, Keith M.u Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland.4 aut |
700 | 1 | a Pass, Harveyu New York Univ Langone Hlth, Dept Surg, New York, NY 10016 USA.4 aut |
700 | 1 | a Nicholson, Andrew G.u Royal Brompton & Harefield NHS Fdn Trust, Dept Pathol, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.4 aut |
700 | 1 | a Mino-Kenudson, Mariu Harvard Med Sch, Dept Pathol, Massachusetts Gen Hosp, Boston, MA 02115 USA.4 aut |
710 | 2 | a New York Univ Langone Hlth, Dept Pathol, 560 First Ave,TH 4-15B, New York, NY 10016 USA.b New York Univ Langone Hlth, Dept Biostat, New York, NY 10016 USA.4 org |
773 | 0 | t Journal of Thoracic Oncologyd : ELSEVIER SCIENCE INCg 15:10, s. 1599-1610q 15:10<1599-1610x 1556-0864x 1556-1380 |
856 | 4 | u http://www.jto.org/article/S1556086420304688/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423938 |
856 | 4 8 | u https://doi.org/10.1016/j.jtho.2020.06.001 |
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