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FältnamnIndikatorerMetadata
00024014naa a2201621 4500
001oai:DiVA.org:uu-427542
003SwePub
008201209s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-175926
009oai:prod.swepub.kib.ki.se:144635887
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4275422 URI
024a https://doi.org/10.1186/s12916-020-01703-w2 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1759262 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1446358872 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Seyed Khoei, Nazlisadatu Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.4 aut
2451 0a Circulating bilirubin levels and risk of colorectal cancer :b serological and Mendelian randomization analyses
264 c 2020-09-03
264 1b Springer Nature,c 2020
338 a electronic2 rdacarrier
520 a BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex.METHODS: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.RESULTS: The associations between circulating UCB levels and CRC risk differed by sex (Pheterogeneity = 0.008). Among men, higher levels of UCB were positively associated with CRC risk (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.04-1.36; per 1-SD increment of log-UCB). In women, an inverse association was observed (OR = 0.86 (0.76-0.97)). In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02-1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96-1.06); P = 0.73). Raised bilirubin levels, predicted by instrumental variables excluding rs6431625, were suggestive of an inverse association with CRC in men, but not in women. These differences by sex did not reach formal statistical significance (Pheterogeneity ≥ 0.2).CONCLUSIONS: Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Anti-oxidants
653 a Bilirubin
653 a Cancer
653 a Colorectal cancer
653 a Mendelian randomization analysis
700a Jenab, Mazdau Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.,Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.4 aut
700a Murphy, Neilu Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.4 aut
700a Banbury, Barbara L.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.,Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.4 aut
700a Carreras-Torres, Robertu Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat, Barcelona, Spain.4 aut
700a Viallon, Vivianu Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.4 aut
700a Kühn, Tilmanu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.4 aut
700a Bueno-de-Mesquita, Basu Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.; Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.4 aut
700a Aleksandrova, Krasimirau Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.4 aut
700a Cross, Amanda J.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.4 aut
700a Weiderpass, Elisabeteu International Agency for Research on Cancer (IARC-WHO), Lyon, France.4 aut
700a Stepien, Magdalenau Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.4 aut
700a Bulmer, Andrewu School of Medicine, Griffith University, Brisbane, QLD, Australia.; Alliance for Vascular Access Teaching and Research (AVATAR), Menzies Health Institute Queensland, Griffith University, Brisbane, QLD, Australia.4 aut
700a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.4 aut
700a Boutron-Ruault, Marie-Christineu CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.; Institut Gustave Roussy, Villejuif, France.4 aut
700a Severi, Gianlucau CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.; Institut Gustave Roussy, Villejuif, France.4 aut
700a Carbonnel, Francku CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.; Institut Gustave Roussy, Villejuif, France.; Department of Gastroenterology, Bicêtre University Hospital, Public Assistance Hospitals of Paris, Le Kremlin Bicêtre, France.4 aut
700a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.4 aut
700a Boeing, Heineru Department of Epidemiology, German Institute of Human Nutrition Postdam-Rehbrücke, Nuthetal, Germany.4 aut
700a Bergmann, Manuela M.u Department of Epidemiology, German Institute of Human Nutrition Postdam-Rehbrücke, Nuthetal, Germany.4 aut
700a Trichopoulou, Antoniau Hellenic Health Foundation, Athens, Greece.4 aut
700a Karakatsani, Annau Hellenic Health Foundation, Athens, Greece.; 2nd Pulmonary Medicine Department, School of Medicine, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Haidari, Greece.4 aut
700a Martimianaki, Georgiau Hellenic Health Foundation, Athens, Greece.4 aut
700a Palli, Domenicou Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy.,Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.4 aut
700a Tagliabue, Giovannau Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.4 aut
700a Panico, Salvatoreu Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.4 aut
700a Tumino, Rosariou Cancer Registry and Histopathology Department, “M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy.4 aut
700a Sacerdote, Carlottau Karolinska Institutet4 aut
700a Skeie, Guriu Department of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT), The Arctic University of Norway, Tromsø, Norway.; Nutritional Epidemiology Group, School of Food and Nutrition, University of Leeds, Leeds, UK.4 aut
700a Merino, Susanau Public Health Directorate, Asturias, Spain.4 aut
700a Bonet, Catalinau Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.4 aut
700a Rodríguez-Barranco, Miguelu Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria, ibs. GRANADA, Universidad de Granada, Granada, Spain.; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.4 aut
700a Gil, Leireu Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain.4 aut
700a Chirlaque, Maria-Doloresu Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain.; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.4 aut
700a Ardanaz, Evau Navarra Public Health Institute, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.4 aut
700a Myte, Robinu Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.4 aut0 (Swepub:umu)romy0001
700a Hultdin, Johanu Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.4 aut0 (Swepub:umu)johu0007
700a Perez-Cornago, Aurorau Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.4 aut
700a Aune, Dagfinnu Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Nutrition, Bjørknes University College, Oslo, Norway.; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.4 aut
700a Tsilidis, Konstantinos K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.4 aut
700a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.4 aut
700a Baron, John A.u Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.4 aut
700a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.4 aut
700a Bézieau, Stéphaneu Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.,Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.4 aut
700a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.4 aut
700a Campbell, Peter T.u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.4 aut
700a Casey, Grahamu Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.4 aut
700a Chan, Andrew T.u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.4 aut
700a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.4 aut
700a Chanock, Stephen J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.4 aut
700a Cotterchio, Michelleu Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.4 aut
700a Gallinger, Stevenu Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.4 aut
700a Gruber, Stephen B.u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.4 aut
700a Haile, Robert W.u Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA.4 aut
700a Hampe, Jochenu Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.4 aut
700a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.4 aut
700a Hopper, John L.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.4 aut
700a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA.4 aut
700a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.4 aut
700a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.4 aut
700a Joshi, Amit D.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.4 aut
700a Kampman, Ellenu Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.4 aut
700a Larsson, Susanna C.u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.4 aut0 (Swepub:uu)susla720
700a Le Marchand, Loicu University of Hawaii Cancer Center, Honolulu, HI, USA.4 aut
700a Li, Christopher I.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.4 aut
700a Li, Liu Department of Family Medicine, University of Virginia, Charlottesville, VA, USA.,Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.,Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.4 aut
700a Lindblom, Annikau Karolinska Institutet4 aut
700a Lindor, Noralane M.u Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.4 aut
700a Martín, Vicenteu CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Biomedicine Institute (IBIOMED), University of León, León, Spain.4 aut
700a Moreno, Victoru Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat, Barcelona, Spain.; Cancer Epidemiology Research Program, Unit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.4 aut
700a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.4 aut
700a Offit, Kennethu Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA.; Department of Medicine, Weill Cornell Medical College, New York, USA.4 aut
700a Ogino, Shujiu Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.4 aut
700a Parfrey, Patrick S.u The Clinical Epidemiology Unit, Memorial University Medical School, Newfoundland, Canada.4 aut
700a Pharoah, Paul D. P.u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.4 aut
700a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.; Clalit National Cancer Control Center, Haifa, Israel.4 aut
700a Sakoda, Lori C.u Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.4 aut
700a Schafmayer, Clemensu Department of General, Visceral, Vascular, and Transplantation Surgery, University Hospital Rostock, Rostock, Germany.4 aut
700a Schmit, Stephanie L.u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.4 aut
700a Schoen, Robert E.u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.4 aut
700a Slattery, Martha L.u Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.4 aut
700a Thibodeau, Stephen N.u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.4 aut
700a Ulrich, Cornelia M.u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.4 aut
700a van Duijnhoven, Franzel J. B.u Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.4 aut
700a Weigl, Korbinianu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty, University of Heidelberg, Heidelberg, Germany.4 aut
700a Weinstein, Stephanie J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.4 aut
700a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.4 aut
700a Wolk, Alicjau Karolinska Institutet4 aut
700a Woods, Michael O.u Discipline of Genetics, Memorial University of Newfoundland, St. John’s, Canada.4 aut
700a Wu, Anna H.u University of Southern California, Preventative Medicine, Los Angeles, CA, USA.4 aut
700a Zhang, Xuehongu Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.4 aut
700a Ferrari, Pietrou Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.4 aut
700a Anton, Gabrieleu Institute of Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.4 aut
700a Peters, Annetteu Institute of Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany.4 aut
700a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.4 aut
700a Gunter, Marc J.u Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.4 aut
700a Wagner, Karl-Heinzu Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.4 aut
700a Freisling, Heinzu Nutritional Methodology and Biostatistics Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France.4 aut
710a Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria.b Nutritional Epidemiology Group, Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.4 org
773t BMC Medicined : Springer Natureg 18:1q 18:1x 1741-7015
856u https://uu.diva-portal.org/smash/get/diva2:1507893/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-020-01703-w
856u https://doi.org/10.1186/s12916-020-01703-wy Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427542
8564 8u https://doi.org/10.1186/s12916-020-01703-w
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175926
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144635887

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