Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

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Fältnamn	Indikatorer	Metadata
000		08837naa a2202137 4500
001		oai:DiVA.org:uu-427567
003		SwePub
008		201209s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:146374388
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4275672 URI
024	7	a https://doi.org/10.1093/jnci/djaa0562 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1463743882 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kapoor, Pooja Middha4 aut
245	1 0	a Combined associations of a polygenic risk score and classical risk factors with breast cancer risk
264		c 2020-05-02
264	1	b Oxford University Press (OUP),c 2021
338		a electronic2 rdacarrier
520		a We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a Breast cancer
653		a Epidemiology
653		a Gene-environment interactions
653		a Genetic susceptibility
653		a Polygenic risk score
653		a Risk factors
653		a Risk prediction
700	1	a Mavaddat, Nasim4 aut
700	1	a Choudhury, Parichoy Pal4 aut
700	1	a Wilcox, Amber N.4 aut
700	1	a Lindström, Sara4 aut
700	1	a Behrens, Sabine4 aut
700	1	a Michailidou, Kyriaki4 aut
700	1	a Dennis, Joe4 aut
700	1	a Bolla, Manjeet K.4 aut
700	1	a Wang, Qin4 aut
700	1	a Jung, Audrey4 aut
700	1	a Abu-Ful, Zomoroda4 aut
700	1	a Ahearn, Thomas4 aut
700	1	a Andrulis, Irene L.4 aut
700	1	a Anton-Culver, Hoda4 aut
700	1	a Arndt, Volker4 aut
700	1	a Aronson, Kristan J.4 aut
700	1	a Auer, Paul L.4 aut
700	1	a Beane Freeman, Laura E.4 aut
700	1	a Becher, Heiko4 aut
700	1	a Beckmann, Matthias W.4 aut
700	1	a Beeghly-Fadiel, Alicia4 aut
700	1	a Benitez, Javier4 aut
700	1	a Bernstein, Leslie4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Brauch, Hiltrud4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Brüning, Thomas4 aut
700	1	a Cai, Qiuyin4 aut
700	1	a Campa, Daniele4 aut
700	1	a Canzian, Federico4 aut
700	1	a Carracedo, Angel4 aut
700	1	a Carter, Brian D.4 aut
700	1	a Castelao, Jose E.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Clarke, Christine L.4 aut
700	1	a Couch, Fergus J.4 aut
700	1	a Cox, Angela4 aut
700	1	a Cross, Simon S.4 aut
700	1	a Czene, Kamilau Karolinska Institutet4 aut
700	1	a Dai, James Y.4 aut
700	1	a Earp, H. Shelton4 aut
700	1	a Ekici, Arif B.4 aut
700	1	a Eliassen, A. Heather4 aut
700	1	a Eriksson, Mikaelu Karolinska Institutet4 aut
700	1	a Evans, D. Gareth4 aut
700	1	a Fasching, Peter A.4 aut
700	1	a Figueroa, Jonine4 aut
700	1	a Fritschi, Lin4 aut
700	1	a Gabrielson, Marikeu Karolinska Institutet4 aut
700	1	a Gago-Dominguez, Manuela4 aut
700	1	a Gao, Chi4 aut
700	1	a Gapstur, Susan M.4 aut
700	1	a Gaudet, Mia M.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a González-Neira, Anna4 aut
700	1	a Guénel, Pascal4 aut
700	1	a Haeberle, Lothar4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Håkansson, Niclasu Karolinska Institutet4 aut
700	1	a Hall, Peru Karolinska Institutet4 aut
700	1	a Hamann, Ute4 aut
700	1	a Hatse, Sigrid4 aut
700	1	a Heyworth, Jane4 aut
700	1	a Holleczek, Bernd4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Hopper, John L.4 aut
700	1	a Howell, Anthony4 aut
700	1	a Hunter, David J.4 aut
700	1	a John, Esther M.4 aut
700	1	a Jones, Michael E.4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Keeman, Renske4 aut
700	1	a Kitahara, Cari M.4 aut
700	1	a Ko, Yon-Dschun4 aut
700	1	a Koutros, Stella4 aut
700	1	a Kurian, Allison W.u Karolinska Institutet4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Lee, Eunjung4 aut
700	1	a Lejbkowicz, Flavio4 aut
700	1	a Linet, Martha4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Llaneza, Ana4 aut
700	1	a MacInnis, Robert J.4 aut
700	1	a Martinez, Maria Elena4 aut
700	1	a Maurer, Tabea4 aut
700	1	a McLean, Catriona4 aut
700	1	a Neuhausen, Susan L.4 aut
700	1	a Newman, William G.4 aut
700	1	a Norman, Aaron4 aut
700	1	a O'Brien, Katie M.4 aut
700	1	a Olshan, Andrew F.4 aut
700	1	a Olson, Janet E.4 aut
700	1	a Olsson, Håkan4 aut
700	1	a Orr, Nick4 aut
700	1	a Perou, Charles M.4 aut
700	1	a Pita, Guillermo4 aut
700	1	a Polley, Eric C.4 aut
700	1	a Prentice, Ross L.4 aut
700	1	a Rennert, Gad4 aut
700	1	a Rennert, Hedy S.4 aut
700	1	a Ruddy, Kathryn J.4 aut
700	1	a Sandler, Dale P.4 aut
700	1	a Saunders, Christobel4 aut
700	1	a Schoemaker, Minouk J.4 aut
700	1	a Schöttker, Ben4 aut
700	1	a Schumacher, Fredrick4 aut
700	1	a Scott, Christopher4 aut
700	1	a Scott, Rodney J.4 aut
700	1	a Shu, Xiao-Ou4 aut
700	1	a Smeets, Ann4 aut
700	1	a Southey, Melissa C.4 aut
700	1	a Spinelli, John J.4 aut
700	1	a Stone, Jennifer4 aut
700	1	a Swerdlow, Anthony J.4 aut
700	1	a Tamimi, Rulla M.4 aut
700	1	a Taylor, Jack A.4 aut
700	1	a Troester, Melissa A.4 aut
700	1	a Vachon, Celine M.4 aut
700	1	a van Veen, Elke M.4 aut
700	1	a Wang, Xiaoliang4 aut
700	1	a Weinberg, Clarice R.4 aut
700	1	a Weltens, Caroline4 aut
700	1	a Willett, Walter4 aut
700	1	a Winham, Stacey J.4 aut
700	1	a Wolk, Alicjau Uppsala universitet,Medicinsk epidemiologi,Karolinska institutet4 aut0 (Swepub:uu)alwol516
700	1	a Yang, Xiaohong R.4 aut
700	1	a Zheng, Wei4 aut
700	1	a Ziogas, Argyrios4 aut
700	1	a Dunning, Alison M.4 aut
700	1	a Pharoah, Paul D. P.4 aut
700	1	a Schmidt, Marjanka K.4 aut
700	1	a Kraft, Peter4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Milne, Roger L.4 aut
700	1	a García-Closas, Montserrat4 aut
700	1	a Chang-Claude, Jenny4 aut
710	2	a Karolinska Institutetb Medicinsk epidemiologi4 org
773	0	t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 113:3, s. 329-337q 113:3<329-337x 0027-8874x 1460-2105
856	4	u https://doi.org/10.1093/jnci/djaa056y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1508008/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/jnci/article-pdf/113/3/329/36419054/djaa056.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427567
856	4 8	u https://doi.org/10.1093/jnci/djaa056
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:146374388

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Av författaren/redakt...: Kapoor, Pooja Mi ...; Mavaddat, Nasim; Choudhury, Paric ...; Wilcox, Amber N.; Lindström, Sara; Behrens, Sabine; visa fler...; Michailidou, Kyr ...; Dennis, Joe; Bolla, Manjeet K ...; Wang, Qin; Jung, Audrey; Abu-Ful, Zomorod ...; Ahearn, Thomas; Andrulis, Irene ...; Anton-Culver, Ho ...; Arndt, Volker; Aronson, Kristan ...; Auer, Paul L.; Beane Freeman, L ...; Becher, Heiko; Beckmann, Matthi ...; Beeghly-Fadiel, ...; Benitez, Javier; Bernstein, Lesli ...; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Brüning, Thomas; Cai, Qiuyin; Campa, Daniele; Canzian, Federic ...; Carracedo, Angel; Carter, Brian D.; Castelao, Jose E ...; Chanock, Stephen ...; Chatterjee, Nila ...; Chenevix-Trench, ...; Clarke, Christin ...; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Dai, James Y.; Earp, H. Shelton; Ekici, Arif B.; Eliassen, A. Hea ...; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter ...; Figueroa, Jonine; Fritschi, Lin; Gabrielson, Mari ...; Gago-Dominguez, ...; Gao, Chi; Gapstur, Susan M ...; Gaudet, Mia M.; Giles, Graham G.; González-Neira, ...; Guénel, Pascal; Haeberle, Lothar; Haiman, Christop ...; Håkansson, Nicla ...; Hall, Per; Hamann, Ute; Hatse, Sigrid; Heyworth, Jane; Holleczek, Bernd; Hoover, Robert N ...; Hopper, John L.; Howell, Anthony; Hunter, David J.; John, Esther M.; Jones, Michael E ...; Kaaks, Rudolf; Keeman, Renske; Kitahara, Cari M ...; Ko, Yon-Dschun; Koutros, Stella; Kurian, Allison ...; Lambrechts, Diet ...; Le Marchand, Loi ...; Lee, Eunjung; Lejbkowicz, Flav ...; Linet, Martha; Lissowska, Jolan ...; Llaneza, Ana; MacInnis, Robert ...; Martinez, Maria ...; Maurer, Tabea; McLean, Catriona; Neuhausen, Susan ...; Newman, William ...; Norman, Aaron; O'Brien, Katie M ...; Olshan, Andrew F ...; Olson, Janet E.; Olsson, Håkan; Orr, Nick; Perou, Charles M ...; Pita, Guillermo; Polley, Eric C.; Prentice, Ross L ...; Rennert, Gad; Rennert, Hedy S.; Ruddy, Kathryn J ...; Sandler, Dale P.; Saunders, Christ ...; Schoemaker, Mino ...; Schöttker, Ben; Schumacher, Fred ...; Scott, Christoph ...; Scott, Rodney J.; Shu, Xiao-Ou; Smeets, Ann; Southey, Melissa ...; Spinelli, John J ...; Stone, Jennifer; Swerdlow, Anthon ...; Tamimi, Rulla M.; Taylor, Jack A.; Troester, Meliss ...; Vachon, Celine M ...; van Veen, Elke M ...; Wang, Xiaoliang; Weinberg, Claric ...; Weltens, Carolin ...; Willett, Walter; Winham, Stacey J ...; Wolk, Alicja; Yang, Xiaohong R ...; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison ...; Pharoah, Paul D. ...; Schmidt, Marjank ...; Kraft, Peter; Easton, Douglas ...; Milne, Roger L.; García-Closas, M ...; Chang-Claude, Je ...; visa färre...

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