Sökning: onr:"swepub:oai:DiVA.org:uu-430223" > Accuracy and precis...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05377naa a2200601 4500 | |
001 | oai:DiVA.org:uu-430223 | |
003 | SwePub | |
008 | 210108s2020 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/300159 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4302232 URI |
024 | 7 | a https://doi.org/10.1186/s40658-020-00347-22 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/3001592 URI |
040 | a (SwePub)uud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sousa, João M.u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)joasi889 |
245 | 1 0 | a Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [11C]PE2I PET-MR brain imaging |
264 | c 2020-12-28 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
338 | a electronic2 rdacarrier | |
500 | a De två första författarna delar förstaförfattarskapet | |
520 | a BACKGROUND: A valid photon attenuation correction (AC) method is instrumental for obtaining quantitatively correct PET images. Integrated PET/MR systems provide no direct information on attenuation, and novel methods for MR-based AC (MRAC) are still under investigation. Evaluations of various AC methods have mainly focused on static brain PET acquisitions. In this study, we determined the validity of three MRAC methods in a dynamic PET/MR study of the brain.METHODS: Nine participants underwent dynamic brain PET/MR scanning using the dopamine transporter radioligand [11C]PE2I. Three MRAC methods were evaluated: single-atlas (Atlas), multi-atlas (MaxProb) and zero-echo-time (ZTE). The 68Ge-transmission data from a previous stand-alone PET scan was used as reference method. Parametric relative delivery (R1) images and binding potential (BPND) maps were generated using cerebellar grey matter as reference region. Evaluation was based on bias in MRAC maps, accuracy and precision of [11C]PE2I BPND and R1 estimates, and [11C]PE2I time-activity curves. BPND was examined for striatal regions and R1 in clusters of regions across the brain.RESULTS: For BPND, ZTE-MRAC showed the highest accuracy (bias < 2%) in striatal regions. Atlas-MRAC exhibited a significant bias in caudate nucleus (- 12%) while MaxProb-MRAC revealed a substantial, non-significant bias in the putamen (9%). R1 estimates had a marginal bias for all MRAC methods (- 1.0-3.2%). MaxProb-MRAC showed the largest intersubject variability for both R1 and BPND. Standardized uptake values (SUV) of striatal regions displayed the strongest average bias for ZTE-MRAC (~ 10%), although constant over time and with the smallest intersubject variability. Atlas-MRAC had highest variation in bias over time (+10 to - 10%), followed by MaxProb-MRAC (+5 to - 5%), but MaxProb showed the lowest mean bias. For the cerebellum, MaxProb-MRAC showed the highest variability while bias was constant over time for Atlas- and ZTE-MRAC.CONCLUSIONS: Both Maxprob- and ZTE-MRAC performed better than Atlas-MRAC when using a 68Ge transmission scan as reference method. Overall, ZTE-MRAC showed the highest precision and accuracy in outcome parameters of dynamic [11C]PE2I PET analysis with use of kinetic modelling. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
653 | a Atlas | |
653 | a Binding potential | |
653 | a Dopamine transporter | |
653 | a MRAC | |
653 | a MaxProb | |
653 | a ZTE | |
653 | a rCBF | |
700 | 1 | a Appel, Lieuweu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)lap02157 |
700 | 1 | a Merida, Inés4 aut |
700 | 1 | a Heckemann, Rolf A.u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics4 aut0 (Swepub:gu)xhecro |
700 | 1 | a Costes, Nicolas4 aut |
700 | 1 | a Engström, Mathias4 aut |
700 | 1 | a Papadimitriou, Stergiosu Uppsala universitet,Landtblom: Neurovetenskap4 aut |
700 | 1 | a Nyholm, Dagu Uppsala universitet,Landtblom: Neurovetenskap4 aut0 (Swepub:uu)danyh856 |
700 | 1 | a Ahlström, Håkan,d 1953-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)hakanahl |
700 | 1 | a Hammers, Alexander4 aut |
700 | 1 | a Lubberink, Marku Uppsala universitet,Radiologi4 aut0 (Swepub:uu)marklubb |
710 | 2 | a Uppsala universitetb Radiologi4 org |
773 | 0 | t EJNMMI Physicsd : Springer Science and Business Media LLCg 7:1q 7:1x 2197-7364 |
856 | 4 | u https://doi.org/10.1186/s40658-020-00347-2y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1515126/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://ejnmmiphys.springeropen.com/track/pdf/10.1186/s40658-020-00347-2 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430223 |
856 | 4 8 | u https://doi.org/10.1186/s40658-020-00347-2 |
856 | 4 8 | u https://gup.ub.gu.se/publication/300159 |
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