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The CD34+ Cell Dose...
The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors
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- Remberger, Mats (author)
- Uppsala universitet,Hematologi,Oslo University Hospital
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Grønvold, B. (author)
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Ali, M. (author)
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- Mattsson, J. (author)
- Karolinska Institutet
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Egeland, T. (author)
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Lundin, K. U. (author)
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Myhre, A. (author)
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Abrahamsen, I. (author)
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Heldal, D. (author)
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Dybedal, I. (author)
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Tjønnfjord, G. E. (author)
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Gedde-Dahl, T. (author)
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Fløisand, Y. (author)
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Clinical Hematology International. - : Springer Science and Business Media LLC. - 2590-0048. ; 2:2, s. 74-81
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Abstract
Subject headings
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- The effect of CD34+ cell dose in allogeneic hematopoietic stem cell transplantation (HSCT) on overall survival (OS) and incidence of acute and chronic graft-versus-host disease (GvHD) has not been established and few studies have been performed. Our single center analysis included 189 patients with hematological malignancies who received peripheral blood stem cell (PBSC) grafts from sibling donors. Myeloablative conditioning was used in 88 cases and 101 received reduced intensity conditioning. The median CD34+ cell dose was 5.6 × 106/kg (0.6–17.0). In the multivariate analysis, a CD34 cell dose of 6–7 × 106/kg was associated with better OS and lower transplant-related mortality (TRM), while a dose of <5 × 106/kg led to increased relapse and reduced chronic GVHD (cGVHD). A high CD34 cell-dose (>6.5 × 106/kg) correlated with less acute GVHD (aGVHD) II–IV. We conclude that the CD34 cell dose has an impact on the outcome of HSCT from sibling donor PBSCs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Cell dose
- CD34
- HSCT
- GVHD
- PBSC
- Klinisk immunologi
- Clinical Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Remberger, Mats
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Grønvold, B.
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Ali, M.
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Mattsson, J.
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Egeland, T.
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Lundin, K. U.
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show more...
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Myhre, A.
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Abrahamsen, I.
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Heldal, D.
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Dybedal, I.
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Tjønnfjord, G. E ...
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Gedde-Dahl, T.
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Fløisand, Y.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Clinical Hematol ...
- By the university
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Uppsala University
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Karolinska Institutet