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Sökning: onr:"swepub:oai:DiVA.org:uu-432655" > Effects of Fecal Mi...

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FältnamnIndikatorerMetadata
00006941naa a2200493 4500
001oai:DiVA.org:uu-432655
003SwePub
008210122s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4326552 URI
0247 a https://doi.org/10.1001/jamanetworkopen.2020.304152 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Leong, Karen S. W.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.4 aut
2451 0a Effects of Fecal Microbiome Transfer in Adolescents With Obesity The Gut Bugs Randomized Controlled Trial
264 c 2020-12-21
264 1b AMER MEDICAL ASSOC,c 2020
338 a electronic2 rdacarrier
520 a Importance Treatment of pediatric obesity is challenging. Preclinical studies in mice indicated that weight and metabolism can be altered by gut microbiome manipulation. Objective To assess efficacy of fecal microbiome transfer (FMT) to treat adolescent obesity and improve metabolism. Design, Setting, and Participants This randomized, double-masked, placebo-controlled trial (October 2017-March 2019) with a 26-week follow-up was conducted among adolescents aged 14 to 18 years with a body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) of 30 or more in Auckland, New Zealand. A total of 87 individuals took part-565 individuals responded to advertisements, 328 were ineligible, and 150 declined participation. Clinical data were analyzed from September 2019 to May 2020. Interventions Single course of oral encapsulated fecal microbiome from 4 healthy lean donors of the same sex or saline placebo. Main Outcomes and Measures Primary outcome was BMI standard deviation score at 6 weeks using intention-to-treat analysis. Secondary outcomes included body composition, cardiometabolic parameters, well-being, and gut microbiome composition. Results Eighty-seven participants (59% female adolescents, mean [SD] age 17.2 [1.4] years) were randomized 1:1, in groups stratified by sex, to FMT (42 participants) or placebo (45 participants). There was no effect of FMT on BMI standard deviation score at 6 weeks (adjusted mean difference [aMD] -0.026; 95% CI -0.074, 0.022). Reductions in android-to-gynoid-fat ratio in the FMT vs placebo group were observed at 6, 12, and 26 weeks, with aMDs of -0.021 (95% CI, -0.041 to -0.001), -0.023 (95% CI, -0.043 to -0.003), and -0.029 (95% CI, -0.049 to -0.008), respectively. There were no observed effects on insulin sensitivity, liver function, lipid profile, inflammatory markers, blood pressure, total body fat percentage, gut health, and health-related quality of life. Gut microbiome profiling revealed a shift in community composition among the FMT group, maintained up to 12 weeks. In post-hoc exploratory analyses among participants with metabolic syndrome at baseline, FMT led to greater resolution of this condition (18 to 4) compared with placebo (13 to 10) by 26 weeks (adjusted odds ratio, 0.06; 95% CI, 0.01-0.45; P = .007). There were no serious adverse events recorded throughout the trial. Conclusions and Relevance In this randomized clinical trial of adolescents with obesite, there was no effect of FMT on weight loss in adolescents with obesity, although a reduction in abdominal adiposity was observed. Post-hoc analyses indicated a resolution of undiagnosed metabolic syndrome with FMT among those with this condition. Further trials are needed to confirm these results and identify organisms and mechanisms responsible for mediating the observed benefits.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Jayasinghe, Thilini N.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.4 aut
7001 a Wilson, Brooke C.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.4 aut
7001 a Derraik, José G. B.u Uppsala universitet,Institutionen för kvinnors och barns hälsa,Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.;Zhejiang Univ, Childrens Hosp, Sch Med, Hangzhou, Peoples R China.4 aut0 (Swepub:uu)josde820
7001 a Albert, Benjamin B.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.4 aut
7001 a Chiavaroli, Valentinau Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy.4 aut
7001 a Svirskis, Darren M.u Univ Auckland, Sch Pharm, Fac Med & Hlth Sci, Auckland, New Zealand.4 aut
7001 a Beck, Kathryn L.u Massey Univ, Sch Sport Exercise & Nutr, Coll Hlth, Auckland, New Zealand.4 aut
7001 a Conlon, Cathryn A.u Massey Univ, Sch Sport Exercise & Nutr, Coll Hlth, Auckland, New Zealand.4 aut
7001 a Jiang, Yannanu Univ Auckland, Dept Stat, Auckland, New Zealand.4 aut
7001 a Schierding, Williamu Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.4 aut
7001 a Vatanen, Tommiu Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
7001 a Holland, David J.u Counties Manukau Dist Hlth Board, Dept Infect Dis, Auckland, New Zealand.4 aut
7001 a O'Sullivan, Justin M.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.;Univ Auckland, Maurice Wilkins Ctr, Auckland, New Zealand.;Univ Southampton, MRC Lifecourse Unit, Southampton, Hants, England.4 aut
7001 a Cutfield, Wayne S.u Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.;Zhejiang Univ, Childrens Hosp, Sch Med, Hangzhou, Peoples R China.4 aut
7102 a Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Better Start Natl Sci Challenge, Auckland, New Zealand.b Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.4 org
7730 t JAMA Network Opend : AMER MEDICAL ASSOCg 3:12q 3:12x 2574-3805
8564 u https://doi.org/10.1001/jamanetworkopen.2020.30415y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1521357/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2774355/leong_2020_oi_200956_1607700283.46455.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-432655
8564 8u https://doi.org/10.1001/jamanetworkopen.2020.30415

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