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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007260naa a2200745 4500
001oai:DiVA.org:uu-446847
003SwePub
008210805s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:154400671
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4468472 URI
0247 a https://doi.org/10.1016/j.lanepe.2021.1000492 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1544006712 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Osterlund, Piau Karolinska Institutet,Tampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.4 aut
2451 0a Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO) :b A nationwide prospective intervention study
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
520 a Background: Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice. Methods: A prospective Finnish nationwide study enrolled treatable metastatic CRC patients. The intervention was the assessment of resectability upfront and twice during first-line therapy by the multidisciplinary team (MDT) at Helsinki tertiary referral centre. The primary outcome was resection rates and survival. Findings: In 2012-2018, 1086 patients were included. Median follow-up was 58 months. Multiple metastatic sites were present in 500 (46%) patients at baseline and in 820 (76%) during disease trajectory. In MDT assessments, 447 (41%) were classified as resectable, 310 (29%) upfront and 137 (18%) after conversion therapy. Sixhundred and ninety curative intent resections or local ablative therapies (LAT) were performed in 399 patients (89% of 447 resectable). Multiple metastasectomies for multisite or later developing metastases were performed in 148 (37%) patients. Overall, 414 liver, 112 lung, 57 peritoneal, and 107 other metastasectomies were performed. Median OS was 80.4 months in R0/1-resected (HR 0.15; CI95% 0.12-0.19), 39.1 months in R2-resected/LAT (0.39; 0.29-0.53) patients, and 20.8 months in patients treated with "systemic therapy alone" (reference), with 5-year OS rates of 66%, 40%, and 6%, respectively. Interpretation: Repeated centralized MDT assessment in real-world metastatic CRC patients generates high resectability (41%) and resection rates (37%) with impressive survival, even when multisite metastases are present or develop later.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Colorectal cancer
653 a Metastatic
653 a Multidisciplinary
653 a Resection
653 a Resectability
653 a Multisite metastases
653 a Conversion
7001 a Salminen, Tapiou Tampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.4 aut
7001 a Soveri, Leena-Maijau Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Hyvinkaa Hosp & Home Care, Dept Palliat Care, Hyvinkaa, Finland.4 aut
7001 a Kallio, Raijau Oulu Univ Hosp, Dept Oncol, Oulu, Finland.;Univ Oulu, Oulu, Finland.4 aut
7001 a Kellokumpu, Ilmou Cent Hosp Cent Finland, Dept Gastrointestinal Surg, Jyyaskyla, Finland.4 aut
7001 a Lamminmäki, Annamarjau Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland.;Univ Kuopio, Kuopio, Finland.4 aut
7001 a Halonen, Päiviu Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.4 aut
7001 a Ristamäki, Raijau Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.4 aut
7001 a Lantto, Eilau Helsinki Univ Hosp, Dept Radiol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.;Paijat Home Cent Hosp, Dept Radiol, Lahti, Finland.4 aut
7001 a Uutela, Akiu Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.4 aut
7001 a Österlund, Emeriku Uppsala universitet,Experimentell och klinisk onkologi,Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.;Akad Sjukhuset, Uppsala, Sweden.4 aut0 (Swepub:uu)emeos639
7001 a Ovissi, Aliu Helsinki Univ Hosp, Dept Radiol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.4 aut
7001 a Nordin, Arnou Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.4 aut
7001 a Heervä, Eetuu Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.4 aut
7001 a Lehtomäki, Kaisau Tampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.4 aut
7001 a Räsänen, Jariu Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Thorac Surg, Helsinki, Finland.4 aut
7001 a Murashev, Maijau Satakunta Cent Hosp, Dept Oncol, Pori, Finland.4 aut
7001 a Aroviita, Laurau Kanta Hame Cent Hosp, Dept Oncol, Hameenlinna, Finland.4 aut
7001 a Jekunen, Anttiu Vaasa Cent Hosp, Dept Oncol, Vaasa, Finland.4 aut
7001 a Lindvall-Andersson, Reneeu Aland Cent Hosp, Dept Oncol, Mariehamn, Finland.4 aut
7001 a Nyandoto, Paulu Paijat Name Cent Hosp, Dept Oncol, Lahti, Finland.4 aut
7001 a Kononen, Juhau Cent Hosp Cent Finland, Dept Oncol, Jyvaskyla, Finland.4 aut
7001 a Lepistö, Annau Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Gastrointestinal Surg, Helsinki, Finland.4 aut
7001 a Poussa, Tuijau StatConsulting, Nokia, Finland.4 aut
7001 a Muhonen, Timou South Carelia Cent Hosp, Dept Oncol, Lappeenranta, Finland.4 aut
7001 a Ålgars, Annikau Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.4 aut
7001 a Isoniemi, Helenau Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Helsinki, Finland.4 aut
7102 a Karolinska Institutetb Tampere Univ Hosp, Dept Oncol, Teiskontie 35,POB 2000, Tampere 33520, Finland.;Univ Tampere, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.4 org
7730 t The Lancet Regional Healthd : Elsevierg 3q 3x 2666-7762
8564 u https://doi.org/10.1016/j.lanepe.2021.100049y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1583254/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.lanepe.2021.100049
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446847
8564 8u https://doi.org/10.1016/j.lanepe.2021.100049
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:154400671

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