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Sökning: onr:"swepub:oai:DiVA.org:uu-448194" > Genome evolution an...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005480naa a2200541 4500
001oai:DiVA.org:uu-448194
003SwePub
008210702s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4481942 URI
0247 a https://doi.org/10.1038/s41467-021-20988-w2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mageiros, Leonardosu Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England4 aut
2451 0a Genome evolution and the emergence of pathogenicity in avian Escherichia coli
264 c 2021-02-03
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
520 a Chickens are the most common birds on Earth and colibacillosis is among the most common diseases affecting them. This major threat to animal welfare and safe sustainable food production is difficult to combat because the etiological agent, avian pathogenic Escherichia coli (APEC), emerges from ubiquitous commensal gut bacteria, with no single virulence gene present in all disease-causing isolates. Here, we address the underlying evolutionary mechanisms of extraintestinal spread and systemic infection in poultry. Combining population scale comparative genomics and pangenome-wide association studies, we compare E. coli from commensal carriage and systemic infections. We identify phylogroup-specific and species-wide genetic elements that are enriched in APEC, including pathogenicity-associated variation in 143 genes that have diverse functions, including genes involved in metabolism, lipopolysaccharide synthesis, heat shock response, antimicrobial resistance and toxicity. We find that horizontal gene transfer spreads pathogenicity elements, allowing divergent clones to cause infection. Finally, a Random Forest model prediction of disease status (carriage vs. disease) identifies pathogenic strains in the emergent ST-117 poultry-associated lineage with 73% accuracy, demonstrating the potential for early identification of emergent APEC in healthy flocks.
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
7001 a Méric, Guillaumeu Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England4 aut
7001 a Bayliss, Sion C.u Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England; MRC Cloud Infrastruct Microbial Bioinformat CLIMB, London, England4 aut
7001 a Pensar, Johanu Univ Oslo, Dept Biostat, Oslo, Norway; Univ Helsinki, Helsinki Inst Informat Technol, Dept Math & Stat, Helsinki, Finland4 aut
7001 a Pascoe, Benu Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England; Univ Oslo, Dept Biostat, Oslo, Norway4 aut
7001 a Mourkas, Evangelosu Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England4 aut
7001 a Calland, Jessica K.u Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England4 aut
7001 a Yahara, Kojiu Natl Inst Infect Dis, Antimicrobial Resistance Res Ctr, Tokyo, Japan4 aut
7001 a Murray, Susanu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)susmu240
7001 a Wilkinson, Thomas S.u Swansea Univ, Inst Life Sci, Med Sch, Swansea SA2 8PP, W Glam, Wales4 aut
7001 a Williams, Lisa K.u Swansea Univ, Inst Life Sci, Med Sch, Swansea SA2 8PP, W Glam, Wales4 aut
7001 a Hitchings, Matthew D.u Swansea Univ, Inst Life Sci, Med Sch, Swansea SA2 8PP, W Glam, Wales4 aut
7001 a Porter, Jonathanu Environm Agcy, Natl Lab Serv, Starcross, England4 aut
7001 a Kemmett, Kirstyu Univ Liverpool, Inst Infect & Global Hlth, Dept Epidemiol & Populat Hlth, Leahurst Campus, Wirral, Merseyside, England4 aut
7001 a Feil, Edward J.u Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England4 aut
7001 a Jolley, Keith A.u Univ Oxford, Dept Zool, South Parks Rd, Oxford OX1 3PS, England4 aut
7001 a Williams, Nicola J.u Univ Liverpool, Inst Infect & Global Hlth, Dept Epidemiol & Populat Hlth, Leahurst Campus, Wirral, Merseyside, England4 aut
7001 a Corander, Jukkau Univ Oslo, Dept Biostat, Oslo, Norway; Univ Helsinki, Helsinki Inst Informat Technol, Dept Math & Stat, Helsinki, Finland; Wellcome Sanger Inst, Parasites & Microbes, Cambridge, England4 aut
7001 a Sheppard, Samuel K.u Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England; MRC Cloud Infrastruct Microbial Bioinformat CLIMB, London, England; Univ Oxford, Dept Zool, South Parks Rd, Oxford OX1 3PS, England4 aut
7102 a Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, Englandb Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath, Avon, England; MRC Cloud Infrastruct Microbial Bioinformat CLIMB, London, England4 org
7730 t Nature Communicationsd : Springer Natureg 12:1q 12:1x 2041-1723
8564 u https://doi.org/10.1038/s41467-021-20988-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1577567/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41467-021-20988-w.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448194
8564 8u https://doi.org/10.1038/s41467-021-20988-w

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