Sökning: onr:"swepub:oai:DiVA.org:uu-453372" > A meta-analysis of ...
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000 | 06921naa a2201381 4500 | |
001 | oai:DiVA.org:uu-453372 | |
003 | SwePub | |
008 | 210916s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:147597035 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4533722 URI |
024 | 7 | a https://doi.org/10.1002/hbm.256252 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475970352 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gutman, Boris A4 aut |
245 | 1 0 | a A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium |
264 | c 2021-09-08 | |
264 | 1 | b John Wiley & Sons,c 2022 |
338 | a print2 rdacarrier | |
520 | a Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a schizophrenia | |
653 | a structure | |
653 | a subcortical shape | |
700 | 1 | a van Erp, Theo G M4 aut |
700 | 1 | a Alpert, Kathryn4 aut |
700 | 1 | a Ching, Christopher R K4 aut |
700 | 1 | a Isaev, Dmitry4 aut |
700 | 1 | a Ragothaman, Anjani4 aut |
700 | 1 | a Jahanshad, Neda4 aut |
700 | 1 | a Saremi, Arvin4 aut |
700 | 1 | a Zavaliangos-Petropulu, Artemis4 aut |
700 | 1 | a Glahn, David C4 aut |
700 | 1 | a Shen, Li4 aut |
700 | 1 | a Cong, Shan4 aut |
700 | 1 | a Alnaes, Dag4 aut |
700 | 1 | a Andreassen, Ole Andreas4 aut |
700 | 1 | a Doan, Nhat Trung4 aut |
700 | 1 | a Westlye, Lars T4 aut |
700 | 1 | a Kochunov, Peter4 aut |
700 | 1 | a Satterthwaite, Theodore D4 aut |
700 | 1 | a Wolf, Daniel H4 aut |
700 | 1 | a Huang, Alexander J4 aut |
700 | 1 | a Kessler, Charles4 aut |
700 | 1 | a Weideman, Andrea4 aut |
700 | 1 | a Nguyen, Dana4 aut |
700 | 1 | a Mueller, Bryon A4 aut |
700 | 1 | a Faziola, Lawrence4 aut |
700 | 1 | a Potkin, Steven G4 aut |
700 | 1 | a Preda, Adrian4 aut |
700 | 1 | a Mathalon, Daniel H4 aut |
700 | 1 | a Bustillo, Juan4 aut |
700 | 1 | a Calhoun, Vince4 aut |
700 | 1 | a Ford, Judith M4 aut |
700 | 1 | a Walton, Esther4 aut |
700 | 1 | a Ehrlich, Stefan4 aut |
700 | 1 | a Ducci, Giuseppe4 aut |
700 | 1 | a Banaj, Nerisa4 aut |
700 | 1 | a Piras, Fabrizio4 aut |
700 | 1 | a Piras, Federica4 aut |
700 | 1 | a Spalletta, Gianfranco4 aut |
700 | 1 | a Canales-Rodríguez, Erick J4 aut |
700 | 1 | a Fuentes-Claramonte, Paola4 aut |
700 | 1 | a Pomarol-Clotet, Edith4 aut |
700 | 1 | a Radua, Joaquim4 aut |
700 | 1 | a Salvador, Raymond4 aut |
700 | 1 | a Sarró, Salvadoru Karolinska Institutet4 aut |
700 | 1 | a Dickie, Erin W4 aut |
700 | 1 | a Voineskos, Aristotle4 aut |
700 | 1 | a Tordesillas-Gutiérrez, Diana4 aut |
700 | 1 | a Crespo-Facorro, Benedicto4 aut |
700 | 1 | a Setién-Suero, Esther4 aut |
700 | 1 | a van Son, Jacqueline Mayoral4 aut |
700 | 1 | a Borgwardt, Stefan4 aut |
700 | 1 | a Schönborn-Harrisberger, Fabienne4 aut |
700 | 1 | a Morris, Derek4 aut |
700 | 1 | a Donohoe, Gary4 aut |
700 | 1 | a Holleran, Laurena4 aut |
700 | 1 | a Cannon, Dara4 aut |
700 | 1 | a McDonald, Colmu Karolinska Institutet4 aut |
700 | 1 | a Corvin, Aiden4 aut |
700 | 1 | a Gill, Michael4 aut |
700 | 1 | a Filho, Geraldo Busatto4 aut |
700 | 1 | a Rosa, Pedro G P4 aut |
700 | 1 | a Serpa, Mauricio H4 aut |
700 | 1 | a Zanetti, Marcus V4 aut |
700 | 1 | a Lebedeva, Irina4 aut |
700 | 1 | a Kaleda, Vasily4 aut |
700 | 1 | a Tomyshev, Alexander4 aut |
700 | 1 | a Crow, Tim4 aut |
700 | 1 | a James, Anthony4 aut |
700 | 1 | a Cervenka, Simon4 aut |
700 | 1 | a Sellgren, Carl M4 aut |
700 | 1 | a Fatouros-Bergman, Helenau Karolinska Institutet4 aut |
700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
700 | 1 | a Howells, Fleur4 aut |
700 | 1 | a Stein, Dan J4 aut |
700 | 1 | a Temmingh, Henk4 aut |
700 | 1 | a Uhlmann, Anne4 aut |
700 | 1 | a de Zubicaray, Greig I4 aut |
700 | 1 | a McMahon, Katie L4 aut |
700 | 1 | a Wright, Margie4 aut |
700 | 1 | a Cobia, Derin4 aut |
700 | 1 | a Csernansky, John G4 aut |
700 | 1 | a Thompson, Paul M4 aut |
700 | 1 | a Turner, Jessica A4 aut |
700 | 1 | a Wang, Lei4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Human Brain Mappingd : John Wiley & Sonsg 43:1, s. 352-372q 43:1<352-372x 1065-9471x 1097-0193 |
856 | 4 | u https://doi.org/10.1002/hbm.25625y Fulltext |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25625 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453372 |
856 | 4 8 | u https://doi.org/10.1002/hbm.25625 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147597035 |
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