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Sökning: onr:"swepub:oai:DiVA.org:uu-458407" > Causal associations...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007420naa a2200565 4500
001oai:DiVA.org:uu-458407
003SwePub
008211110s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147906915
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4584072 URI
0247 a https://doi.org/10.1093/eurheartj/ehab1702 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1479069152 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ai, Sizhiu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut
2451 0a Causal associations of short and long sleep durations with 12 cardiovascular diseases :b linear and nonlinear Mendelian randomization analyses in UK Biobank
264 c 2021-04-05
264 1b Oxford University Press,c 2021
338 a print2 rdacarrier
520 a Aims Observational studies have suggested strong associations between sleep duration and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed. We aimed to determine the causal associations between genetically predicted sleep duration and 12 CVDs using both linear and nonlinear Mendelian randomization (MR) designs. Methods and results Genetic variants associated with continuous, short (<= 6 h) and long (>= 9 h) sleep durations were used to examine the causal associations with 12 CVDs among 404 044 UK Biobank participants of White British ancestry. Linear MR analyses showed that genetically predicted sleep duration was negatively associated with arterial hypertension, atrial fibrillation, pulmonary embolism, and chronic ischaemic heart disease after correcting for multiple tests (P <0.001). Nonlinear MR analyses demonstrated nonlinearity (L-shaped associations) between genetically predicted sleep duration and four CVDs, including arterial hypertension, chronic ischaemic heart disease, coronary artery disease, and myocardial infarction. Complementary analyses provided confirmative evidence of the adverse effects of genetically predicted short sleep duration on the risks of 5 out of the 12 CVDs, including arterial hypertension, pulmonary embolism, coronary artery disease, myocardial infarction, and chronic ischaemic heart disease (P< 0.001), and suggestive evidence for atrial fibrillation (P < 0.05). However, genetically predicted long sleep duration was not associated with any CVD. Conclusion This study suggests that genetically predicted short sleep duration is a potential causal risk factor of several CVDs, while genetically predicted long steep duration is unlikely to be a causal risk factor for most CVDs. [GRAPHICS] .
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Short steep duration
653 a Long steep duration
653 a Cardiovascular disease
653 a Mendelian randomization
653 a Linear
653 a Nonlinear
7001 a Zhang, Jihuiu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Southern Med Univ, Sch Clin Med 2, 253 Ind Ave Middle, Guangzhou 510280, Peoples R China.4 aut
7001 a Zhao, Guoanu Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut
7001 a Wang, Ningjianu Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Mfg Bur Rd, Shanghai 200011, Peoples R China.4 aut
7001 a Li, Guohuau Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.4 aut
7001 a So, Hon-Cheongu Chinese Univ Hong Kong, Fac Med,Sch Biomed Sci,Sha Tin Dist, Horse Mat Water,Cheung Res Ctr Management Parkins, Dept Psychiat,KIZ CUHK Joint Lab Bioresources & M, Da Xue Rd, Hong Kong 000000, Peoples R China.4 aut
7001 a Liu, Yapingu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut
7001 a Chau, Steven Wai-Hou Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut
7001 a Chen, Jieu Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut
7001 a Tan, Xiaou Karolinska Institutet,Uppsala universitet,Schiöth: Funktionell farmakologi4 aut0 (Swepub:uu)xzata683
7001 a Jia, Fujunu Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.4 aut
7001 a Tang, Xiangdongu Sichuan Univ, State Key Lab Biotherapy,West China Hosp, Sleep Med Ctr,Mental Hlth Ctr, Translat Neurosci Ctr,Dept Resp & Crit Care Med, 37 Guoxue Alley, Chengdu 610041, Peoples R China.4 aut
7001 a Shi, Jieu Peking Univ, Peking Univ Hosp 6, Natl Inst Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China.4 aut
7001 a Lu, Linu Peking Univ, Peking Univ Hosp 6, Natl Inst Drug Dependence, 38 Xueyuan Rd, Beijing 100191, Peoples R China.4 aut
7001 a Wing, Yun-Kwoku Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.4 aut
7102 a Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Xinxiang Med Univ, Heart Ctr, Dept Cardiol, Affiliated Hosp 1, 88 Jiankang Rd, Weihui 453100, Peoples R China.b Chinese Univ Hong Kong, Fac Med, Sha Tin Dist,Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, 33 A Kung Kok St, Hong Kong 000000, Peoples R China.;Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Mental Hlth Ctr, Yuexiu Dist, 123 Huifu West Rd, Guangzhou 510000, Peoples R China.;Southern Med Univ, Sch Clin Med 2, 253 Ind Ave Middle, Guangzhou 510280, Peoples R China.4 org
7730 t European Heart Journald : Oxford University Pressg 42:34, s. 3349-3357q 42:34<3349-3357x 0195-668Xx 1522-9645
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458407
8564 8u https://doi.org/10.1093/eurheartj/ehab170
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147906915

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