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Sökning: onr:"swepub:oai:DiVA.org:uu-458805" > Key Characteristics...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005902naa a2200517 4500
001oai:DiVA.org:uu-458805
003SwePub
008211119s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4588052 URI
0247 a https://doi.org/10.1289/EHP93212 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind
2451 0a Key Characteristics of Cardiovascular Toxicants
264 1b US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE,c 2021
338 a electronic2 rdacarrier
520 a BACKGROUND: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches. OBJECTIVES: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them. METHODS: An expert working group was convened to discuss mechanisms associated with CV toxicity. RESULTS: The group identified 12 KCs of CV toxicants, defined as exogenous agents that adversely interfere with function of the CV system. The KCs were organized into those primarily affecting cardiac tissue (numbers 1-4 below), the vascular system (5-7), or both (8-12), as follows: 1) impairs regulation of cardiac excitability, 2) impairs cardiac contractility and relaxation, 3) induces cardiomyocyte injury and death, 4) induces proliferation of valve stroma, 5) impacts endothelial and vascular function, 6) alters hemostasis, 7) causes dyslipidemia, 8) impairs mitochondrial function, 9) modifies autonomic nervous system activity, 10) induces oxidative stress, 11) causes inflammation, and 12) alters hormone signaling. DISCUSSION: These 12 KCs can be used to help identify pharmaceuticals and environmental pollutants as CV toxicants, as well as to better understand the mechanistic underpinnings of their toxicity. For example, evidence exists that fine particulate matter [PM <= 2.5 mu m in aerodynamic diameter (PM2.5)] air pollution, arsenic, anthracycline drugs, and other exogenous chemicals possess one or more of the described KCs. In conclusion, the KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
7001 a Araujo, Jesus A.u UCLA, Univ Calif Angeles UCLA, David Geffen Sch Med, Div Cardiol, Los Angeles, CA USA.;UCLA, Fielding Sch Publ Hlth & Mol Biol Inst, Dept Environm Hlth Sci, Los Angeles, CA USA.4 aut
7001 a Barchowsky, Aaronu Univ Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA USA.4 aut
7001 a Belcher, Scottu North Carolina State Univ, Dept Biol Sci, Raleigh, NC USA.4 aut
7001 a Berridge, Brian R.u Natl Inst Environm Hlth Sci, Natl Inst Hlth, Dept Hlth & Human Serv, Div Natl Toxicol Program, Res Triangle Pk, NC USA.4 aut
7001 a Chiamvimonvat, Nipavanu Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.4 aut
7001 a Chiu, Weihsueh A.u Texas A&M Univ, Coll Vet Med & Biomed Sci, College Pk, MD 95616 USA.4 aut
7001 a Cogliano, Vincent J.u Calif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA.4 aut
7001 a Elmore, Sarahu Calif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA.4 aut
7001 a Farraj, Aimen K.u US EPA, Ctr Publ Hlth & Environm, Publ Hlth & Integrated Toxicol Div, Res Triangle Pk, NC 27711 USA.4 aut
7001 a V. Gomes, Aldrinu Univ Calif Davis, Coll Biol Sci, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA.4 aut
7001 a McHale, Cliona M.u Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, 5 123 Berkeley Way West, Berkeley, CA 94720 USA.4 aut
7001 a Meyer-Tamaki, Kathleen B.u Sangamo Therapeut, Brisbane, CA USA.4 aut
7001 a Posnack, Nikki Gillumu Natl Childrens Hosp, Childrens Natl Heart Inst, Washington, DC USA.;Natl Childrens Hosp, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA.4 aut
7001 a Vargas, Hugo M.u Amgen Inc, Translat Safety & Bioanalyt Sci, Thousand Oaks, CA 91320 USA.4 aut
7001 a Yang, Xiu Food & Drug Adm, Ctr Drug Evaluat & Res, Off Cardiol Hematol Endocrinol & Nephrol, Div Pharmacol & Toxicol, Silver Spring, MD USA.4 aut
7001 a Zeise, Laurenu Calif Environm Protect Agcy EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA.4 aut
7001 a Zhou, Changchengu Univ Calif Riverside, Sch Med, Div Biomed Sci, Riverside, CA 92521 USA.4 aut
7001 a Smith, Martyn T.u Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, 5 123 Berkeley Way West, Berkeley, CA 94720 USA.4 aut
7102 a Uppsala universitetb Klinisk epidemiologi4 org
7730 t Journal of Environmental Health Perspectivesd : US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCEg 129:9q 129:9x 0091-6765x 1552-9924
8564 u https://doi.org/10.1289/EHP9321y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1612870/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458805
8564 8u https://doi.org/10.1289/EHP9321

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