Evaluation of dyskerin expression and the Cajal body protein WRAP53 beta as potential prognostic markers for patients with primary vaginal carcinoma

Ranhem, CeciliaUppsala universitet,Centrum för klinisk forskning, Västerås,Karolinska Inst, Dept Womens & Childrens Hlth, Tomtebodavagen 18A, S-17177 Stockholm, Sweden (author)

Primary vaginal cancer (PVC) is a rare gynaecological malignancy, which, at present, lacks appropriate biomarkers for prognosis. The proteins dyskerin and WD repeat containing antisense to TP53 (WRAP53 beta), both of which exert their functions in the telomerase holoenzyme complex, have been shown to be upregulated in different cancer types. These proteins have also been proposed as prognostic markers in some types of cancer. The aim of the present study was to examine the expression patterns of dyskerin and WRAP53 beta in patients with PVC. Moreover, as part of a search for effective biomarkers to evaluate prognosis in PVC, the expression of these two proteins and their potential association with clinical variables and survival were also evaluated. The expression of dyskerin and WRAP53 beta was assessed in PVC tumour samples from 68 patients using immunohistochemistry. The majority of tumour samples showed low and moderate expression levels of dyskerin. Upregulation of dyskerin in tumour samples was significantly associated with a shorter survival time and a poorer cancer-specific survival rate. WRAP53 beta was also expressed in most of the cells but was not significantly associated with clinical variables or survival. This study demonstrates that upregulation of dyskerin is significantly associated with poor prognosis. Thus, dyskerin may serve as a promising prognostic marker and a potential putative therapeutic target in PVC.

Larsson, GabriellaOrebro Univ, Sch Hlth & Med Sci, Campus USO, S-70182 Orebro, Sweden.;Orebro Univ Hosp, Dept Lab Med, S-70185 Orebro, Sweden. (author)
Lindqvist, DavidUmea Univ, Dept Radiat Sci, S-90187 Umea, Sweden. (author)
Sorbe, BengtOrebro Univ Hosp, Dept Oncol, Orebro, Sweden. (author)
Karlsson, MatsOrebro Univ, Sch Med Sci, S-70185 Orebro, Sweden. (author)
Farnebo, MarianneKarolinska Inst, Dept Biosci & Nutr, S-14183 Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden. (author)
Hellman, KristinaKarolinska Inst, Dept Oncol Pathol, S-17164 Stockholm, Sweden. (author)
Kovaleska, LarysaNatl Acad Sci Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine. (author)
Kashuba, ElenaNatl Acad Sci Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine.;Karolinska Inst, Dept Microbiol Tumour & Cell Biol, S-17165 Stockholm, Sweden. (author)
Andersson, SoniaKarolinska Inst, Dept Womens & Childrens Hlth, Tomtebodavagen 18A, S-17177 Stockholm, Sweden. (author)
Uppsala universitetCentrum för klinisk forskning, Västerås (creator_code:org_t)

By the author/editor: Ranhem, Cecilia; Larsson, Gabriel ...; Lindqvist, David; Sorbe, Bengt; Karlsson, Mats; Farnebo, Mariann ...; show more...; Hellman, Kristin ...; Kovaleska, Larys ...; Kashuba, Elena; Andersson, Sonia; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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