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Phosphorylation of ...
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
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Rondinone, C M (författare)
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Carvalho, E (författare)
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Rahn, T (författare)
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Manganiello, V C (författare)
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- Degerman, Eva (författare)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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Smith, U P (författare)
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 275:14, s. 10093-10098
- Relaterad länk:
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http://www.jbc.org/c... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Phosphatidylinositol 3-kinase mediates several actions of insulin including its antilipolytic effect. This effect is elicited by the insulin-stimulated serine phosphorylation and activation of cGMP-inhibited phosphodiesterase (PDE3B). In human adipocytes, we found that insulin differentially stimulated phosphatidylinositol 3-kinase activity; the lipid kinase activity was associated with IRS-1, whereas the serine kinase activity was associated with the insulin receptor and phosphorylated a number of proteins including p85, p110, and a 135-kDa protein identified as PDE3B. PDE3B phosphorylation was associated with enzyme activation, thus initiating the antilipolytic effect of insulin. These results show a novel pathway for intracellular signaling through the insulin receptor leading to the serine phosphorylation of key proteins involved in insulin action.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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