Sökning: onr:"swepub:oai:DiVA.org:uu-472404" > Temporal distributi...
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000 | 18481naa a2201609 4500 | |
001 | oai:DiVA.org:uu-472404 | |
003 | SwePub | |
008 | 220419s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:149135963 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4724042 URI |
024 | 7 | a https://doi.org/10.1186/s12936-021-03980-z2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1491359632 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dahal, Prabinu World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.4 aut |
245 | 1 0 | a Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy :b an individual participant data meta-analysis |
264 | c 2022-03-24 | |
264 | 1 | b Springer Nature,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a Background: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria.Methods: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up.Results: Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged < 5 years) and 23 studies conducted in Asia and South America (5272 patients of all ages). Using molecular genotyping, 519 (14.0%) recurrences were ascribed as recrudescent infections. A 28 day artemether-lumefantrine (AL) efficacy trial would not have detected 58% [95% confidence interval (CI) 47-74%] of recrudescences in African children and 32% [95% CI 15-45%] in patients of all ages in Asia/South America. The corresponding estimate following a 42 day dihydroartemisinin-piperaquine (DP) efficacy trial in Africa was 47% [95% CI 19-90%] in children under 5 years old treated with > 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0-22%] in those treated with <= 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up following AL underestimated the risk of recrudescence by a median of 2.8 percentage points compared to day 63 estimates and those limited to 42 days following DP underestimated the risk of recrudescence by a median of 2.0 percentage points compared to day 42 estimates. The analysis was limited by few clinical trials following patients for longer than 42 days (9 out of 83 trials) and the imprecision of PCR genotyping which overcalls recrudescence in areas of higher transmission biasing the later distribution.Conclusions: Restricting follow-up of clinical efficacy trials to day 28 for AL and day 42 for DP will miss a proportion of late recrudescent treatment failures but will have a modest impact in derived efficacy. The results highlight that as genotyping methods improve consideration should be given for trials with longer duration of follow-up to detect early indications of emerging drug resistance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a Malaria | |
653 | a Plasmodium falciparum | |
653 | a Efficacy | |
653 | a Follow-up | |
653 | a Recrudescence | |
653 | a Distribution | |
700 | 1 | a Simpson, Julie Anneu Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.4 aut |
700 | 1 | a Abdulla, Salimu Ifakara Hlth Inst, Dar Es Salaam, Tanzania.4 aut |
700 | 1 | a Achan, Janeu Malaria Consortium, London, England.4 aut |
700 | 1 | a Adam, Ishagu Univ Khartoum, Fac Med, Khartoum, Sudan.4 aut |
700 | 1 | a Agarwal, Aartiu New York City Dept Hlth & Mental Hyg, New York, NY USA.4 aut |
700 | 1 | a Allan, Richardu Mentor Initiat, Chicago, IL USA.4 aut |
700 | 1 | a Anvikar, Anupkumar R.u Natl Inst Malaria Res, Sect 8, New Delhi 110077, Uganda.4 aut |
700 | 1 | a Ashley, Elizabeth A.u Myanmar Oxford Clin Res Unit, Yangon, Myanmar.;Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.;Nangarhar Univ, Med Fac, Ghulam Rahim Awab, Afghanistan.;MORU Trop Hlth Network, Bangkok, Thailand.4 aut |
700 | 1 | a Bassat, Quiqueu Ctr Invest Manhica CISM, Maputo, Mozambique.;Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain.;ICREA, Pg Lluis Co 23, Barcelona 08010, Spain.;Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain.;Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden.4 aut |
700 | 1 | a Borrmann, Steffenu Univ Tubingen, Inst Trop Med, Tubingen, Germany.;Kenya Med Res Inst Wellcome Trust Res Programme, Kilifi, Kenya.;Heidelberg Univ, Dept Infect Dis, Sch Med, Heidelberg, Germany.4 aut |
700 | 1 | a Bousema, Teunu Radboudumc Nijmegen, Radboud Inst Hlth Sci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, Njimegen, Netherlands.4 aut |
700 | 1 | a Bukirwa, Hasifau African Field Epidemiol Network, Kampala, Uganda.4 aut |
700 | 1 | a Carrara, Verena, Iu Shoklo Malaria Res Unit, Mae Sot, Thailand.;Mahidol Oxford Univ Res Unit, Bangkok, Thailand.4 aut |
700 | 1 | a Corsi, Marcou Sigma Tau SpA Ind Farmaceut Riunite, Private Consultancy Drug Dev Trop Dis, Rome, Italy.;Univ Paris, MERIT, IRD, F-75006 Paris, France.4 aut |
700 | 1 | a D'Alessandro, Umbertou London Sch Hyg & Trop Med, Med Res Council Unit Gambia, Fajara, Gambia.;London Sch Hyg & Trop Med, London, England.4 aut |
700 | 1 | a Davis, Timothy M. E.u Univ Western Australia, Med Sch, Crawley, WA, Australia.4 aut |
700 | 1 | a Deloron, Philippeu Univ Paris, MERIT, IRD 216, F-75006 Paris, France.4 aut |
700 | 1 | a Desai, Meghnau Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA.4 aut |
700 | 1 | a Dimbu, Pedro Rafaelu Natl Malaria Control Program, Luanda, Angola.4 aut |
700 | 1 | a Djalle, Djibrineu Inst Pasteur, BP 923, Bangui, Cent Afr Republ.4 aut |
700 | 1 | a Djimde, Abdoulayeu Univ Sci Tech & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali.4 aut |
700 | 1 | a Dorsey, Grantu Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Drakeley, Chris J.u London Sch Hyg & Trop Med, Dept Infect Biol, London, England.4 aut |
700 | 1 | a Duparc, Stephanu Med Malaria Venture, Geneva, Switzerland.4 aut |
700 | 1 | a Edstein, Michael D.u Australian Def Force Malaria & Infect Dis Inst, Brisbane, Qld, Australia.4 aut |
700 | 1 | a Espie, Emmanuelleu GSK Vaccines, R&D Ctr, Clin & Epidemiol Dept, Ave Fleming 20, B-1300 Wavre, Belgium.;Epicentre, 8 Rue St Sabin, F-75011 Paris, France.4 aut |
700 | 1 | a Faiz, Abul4 aut |
700 | 1 | a Falade, Catherineu Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria.4 aut |
700 | 1 | a Fanello, Caterinau Univ Oxford, Ctr Global Hlth, Nuffield Dept Med, Oxford, England.4 aut |
700 | 1 | a Faucher, Jean-Francoisu INSERM, U1094, Trop Neuroepidemiol, Limoges, France.;Dept Infect Dis & Trop Med, F-87042 Limoges, France.4 aut |
700 | 1 | a Faye, Babacaru Univ Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal.4 aut |
700 | 1 | a Fortes, Filomeno de Jesusu Univ Nova Lisboa Portugal, Inst Hyg & Trop Med, Lisbon, Portugal.4 aut |
700 | 1 | a Gadalla, Nahla B.u Sudanese Amer Med Assoc, Fairfax, VA USA.4 aut |
700 | 1 | a Gaye, Oumaru Univ Cheikh Anta Diop, Dept Med Parasitol, Med Fac, Dakar, Senegal.4 aut |
700 | 1 | a Gil, J. Pedrou Karolinska Institutet4 aut |
700 | 1 | a Gilayeneh, Juliusu Minist Hlth, Natl Malaria Control Program, Monrovia, Liberia.4 aut |
700 | 1 | a Greenwood, Brianu London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England.4 aut |
700 | 1 | a Grivoyannis, Anastasiau Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.4 aut |
700 | 1 | a Hien, Tran Tinhu Oxford Univ Clin Res Unit OUCRU, Ctr Trop Med, Wellcome Trust Major Overseas Program MOP, Oxford, England.4 aut |
700 | 1 | a Hwang, Jimeeu US Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA.;Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Janssens, Bartu Med Sans Frontieres, Brussels, Belgium.4 aut |
700 | 1 | a Juma, Elizabethu Kenya Govt Med Res Ctr, Nairobi, Kenya.4 aut |
700 | 1 | a Kamugisha, Erasmusu Catholic Univ Hlth & Allied Sci, Mwanza, Tanzania.4 aut |
700 | 1 | a Karema, Corineu Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Univ Basel, Basel, Switzerland.4 aut |
700 | 1 | a Karunajeewa, Harin A.u Univ Melbourne, Melbourne Med Sch, Western Hlth, Melbourne, Vic, Australia.;Sunshine Hosp, Western Hlth Chron Dis Alliance, Furlong Rd, St Albans, Vic 3021, Australia.4 aut |
700 | 1 | a Kiechel, Jean R.u Drugs Neglected Dis Initiat, Geneva, Switzerland.4 aut |
700 | 1 | a Kironde, Fredu Islamic Univ Uganda, Fac Hlth Sci, Dept Microbiol, Mbale, Uganda.4 aut |
700 | 1 | a Kofoed, Poul-Eriku Indepth Network, Bandim Hlth Project, Apartado 861, Bissau, Guinea Bissau.;Kolding Cty Hosp, Dept Paediat, Kolding, Denmark.;Univ Southern Denmark, IRS, Aarhus, Denmark.4 aut |
700 | 1 | a Kremsner, Peter G.u Univ Tubingen, Inst Trop Med, Tubingen, Germany.;Ctr Rech Med Lambarene, Lambarene, Gabon.4 aut |
700 | 1 | a Lee, Sue J.u Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand.4 aut |
700 | 1 | a Marsh, Kevinu Univ Oxford, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.;Kenya Med Res Inst Wellcome Trust Res Programme, Kilifi, Kenya.4 aut |
700 | 1 | a Mårtensson, Andreas,d 1963-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)andma331 |
700 | 1 | a Mayxay, Mayfongu Mahosot Hosp, Lao Oxford Mahosot Hosp Wellcome Trust Res Unit, Microbiol Lab, Viangchan, Laos.;Churchill Hosp, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England.4 aut |
700 | 1 | a Menan, Herveu Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire.4 aut |
700 | 1 | a Mens, Petrau Amsterdam Univ Med Ctr, Parasitol, Med Microbiol, Amsterdam, Netherlands.4 aut |
700 | 1 | a Mutabingwa, Theonest K.u Hubert Kairuki Mem Univ, Dar Es Salaam, Tanzania.;London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London, England.4 aut |
700 | 1 | a Ndiaye, Jean-Louisu Univ Thies, Dept Parasitol & Mycol, Hlth Sci Res & Training Unit, Thies, Senegal.4 aut |
700 | 1 | a Ngasala, Billyu Uppsala universitet,Internationell barnhälsa och nutrition,Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania.4 aut0 (Swepub:uu)bilng827 |
700 | 1 | a Noedl, Haraldu Malaria Res Initiat, Bandarban, Bangladesh.4 aut |
700 | 1 | a Nosten, Francoisu Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med Res Bldg,Old Rd Campus, Oxford, England.;Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand.4 aut |
700 | 1 | a Offianan, Andre Toureu Inst Pasteur Cote Ivoire, Malariol Dept, Abidjan, Cote Ivoire.4 aut |
700 | 1 | a Ogutu, Bernhards R.u Kenya Govt Med Res Ctr, US Army Med Res Unit, Kisumu, Kenya.4 aut |
700 | 1 | a Olliaro, Piero L.u Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.4 aut |
700 | 1 | a Ouedraogo, Jean Boscou Inst Rech Sci Sante IRSS, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso.;Ctr Muraz Bobo Dioulasso, Non Transmissible Dis Dept, Bobo Dioulasso, Burkina Faso.;Ctr Muraz Bobo Dioulasso, Non Transmissible Dis Dept, Bobo Dioul Asso, Burkina Faso.4 aut |
700 | 1 | a Piola, Patriceu Inst Pasteur Cambodge, Phnom Penh, Cambodia.4 aut |
700 | 1 | a Plowe, Christopher, Vu Duke Univ, Duke Global Hlth Inst, Durham, NC USA.4 aut |
700 | 1 | a Plucinski, Mateusz M.u US Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA.;Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.4 aut |
700 | 1 | a Pratt, Oliver Jamesu Minist Hlth & Social Welf, Natl Malaria Control Program, Monrovia, Liberia.4 aut |
700 | 1 | a Premji, Zulfikaraliu Muhimbili Univ, Coll Hlth Sci, Dar Es Salaam, Tanzania.4 aut |
700 | 1 | a Ramharter, Michaelu Univ Med Ctr Hamburg Eppendorf, Dept Trop Med, Bernhard Nocht Inst Trop Med, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany.;Univ Tubingen, Inst Tropenmed, Tubingen, Germany.4 aut |
700 | 1 | a Rogier, Christopheu Inst Pasteur, BP 923, Bangui, Cent Afr Republ.;French Armed Forces Biomed Res Inst IRBA, Marseille, France.4 aut |
700 | 1 | a Vitare, Primumu Ifakara Hlth Inst, Dar Es Salaam, Tanzania.4 aut |
700 | 1 | a Rombo, Larsu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)larra728 |
700 | 1 | a Rosenthal, Philip J.u Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.4 aut |
700 | 1 | a Sibley, Carolu World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Washington, Dept Genome Sci, Seattle, WA USA.4 aut |
700 | 1 | a Sirima, Sodiomonu Grp Rech Act Sante GRAS, 06 BP 10248, Ouagadougou 06, Burkina Faso.4 aut |
700 | 1 | a Smithuis, Franku Myanmar Oxford Clin Res Unit, Oxford, England.;Med Act Myanmar, Yangon, Myanmar.4 aut |
700 | 1 | a Staedke, Sarah G.u Infect Dis Res Collaborat, Kampala, Uganda.;London Sch Hyg & Trop Med, Dept Clin Res, London, England.4 aut |
700 | 1 | a Sutanto, Ingeu Univ Indonesia, Fac Med, Dept Parasitol, 6 Salemba Raya, Jakarta 10430, Indonesia.4 aut |
700 | 1 | a Talisuna, Ambrose Otauu World Hlth Org, Reg Off Africa, Brazzaville, Rep Congo.4 aut |
700 | 1 | a Tarning, Joelu Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;WorldWide Antimalarial Resistance Network, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.4 aut |
700 | 1 | a Taylor, Walter R. J.u Ctr Rech Med Lambarene, Lambarene, Gabon.;Mahidol Univ, Fac Trop Med, Bangkok, Thailand.4 aut |
700 | 1 | a Temu, Emmanuelu UNOPS RBM Partnership End Malaria, Geneva, Switzerland.4 aut |
700 | 1 | a Thriemer, Kamalau Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.4 aut |
700 | 1 | a Thuy-Nhien, Nguyenu Oxford Univ Clin Res Unit OUCRU, Ctr Trop Med, Wellcome Trust Major Overseas Program MOP, Oxford, England.4 aut |
700 | 1 | a Udhayakumar, Venkatachalamu Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.;Ctr Dis Control & Prevent, Presidents Malaria Initiat, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA.4 aut |
700 | 1 | a Ursing, Johan D.u Indepth Network, Bandim Hlth Project, Apartado 861, Bissau, Guinea Bissau.;Danderyd Hosp, Karolinska Inst, Epartment Clin Sci, Stockholm, Sweden.;Danderyd Hosp, Dept Infect Dis, Stockholm, Sweden.4 aut |
700 | 1 | a van Herp, Michelu Operat Ctr Brussels, Med Sans Frontieres, Brussels, Belgium.4 aut |
700 | 1 | a van Lenthe, Maritu Med Sans Frontieres Operat Ctr Amsterdam, Amsterdam, Netherlands.4 aut |
700 | 1 | a van Vugt, Micheleu Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Div Infect Dis, Amsterdam, Netherlands.4 aut |
700 | 1 | a William, Yavou Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire.4 aut |
700 | 1 | a Winnips, Cornelisu Novartis Int AG, Basel, Switzerland.4 aut |
700 | 1 | a Zaloumis, Sophie4 aut |
700 | 1 | a Zongo, Issakau Inst Rech Sci Sante IRSS, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso.4 aut |
700 | 1 | a White, Nick J.u Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Mahidol Oxford Res Unit, Bangkok, Thailand.4 aut |
700 | 1 | a Guerin, Philippe J.u World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.4 aut |
700 | 1 | a Stepniewska, Kasiau World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.4 aut |
700 | 1 | a Price, Ric N.u World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.;Menzies Sch Hlth Res, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT, Australia.4 aut |
700 | 1 | a Arinaitwe, Emmanuelu Infect Dis Res Collaborat, Kampala, Uganda.4 aut |
710 | 2 | a World Wide Antimalarial Resistance Network WWARN, Oxford, England.;Infect Dis Data Observ IDDO, Oxford, England.;Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.b Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.4 org |
773 | 0 | t Malaria Journald : Springer Natureg 21q 21x 1475-2875 |
856 | 4 | u https://doi.org/10.1186/s12936-021-03980-zy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1652695/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-472404 |
856 | 4 8 | u https://doi.org/10.1186/s12936-021-03980-z |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149135963 |
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