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Sökning: onr:"swepub:oai:DiVA.org:uu-473585" > Health-Related Qual...

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FältnamnIndikatorerMetadata
00008756naa a2200721 4500
001oai:DiVA.org:uu-473585
003SwePub
008220429s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:149311185
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4735852 URI
0247 a https://doi.org/10.3390/cancers140717132 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1493111852 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lehtomaki, Kaisau Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.4 aut
2451 0a Health-Related Quality of Life in Metastatic Colorectal Cancer Patients Treated with Curative Resection and/or Local Ablative Therapy or Systemic Therapy in the Finnish RAXO-Study
264 c 2022-03-28
264 1b MDPI,c 2022
338 a electronic2 rdacarrier
520 a Metastatic colorectal cancer is the second most common cause of cancer death. Long-term survival and cure can be achieved after intensive treatments, including metastasectomy, i.e., the removal of all metastases. We wanted to clarify whether a patient health-related quality of life (HRQoL) was reduced by treatments that aimed to maximise metastasectomy rates, and whether HRQoL of treated patients is comparable to the general population. In a cross-sectional study of 444 patients (1751 questionnaires) in the RAXO-study population, we show that HRQoL of intensively treated patients, sometimes with multiple and multisite metastasectomies-usually combined with systemic therapy-remains at a high level during and after curative treatment and when compared with the general population. Good HRQoL was also seen during non-curative treatment from first- to later-lines, with an impaired HRQoL only at end-of-life. Thus, we should aim at maximising metastasectomies since they give long-term survival and sometimes cure with a high HRQoL. Metastasectomy and/or local ablative therapy in metastatic colorectal cancer (mCRC) patients often provide long-term survival. Health-related quality of life (HRQoL) data in curatively treated mCRC are limited. In the RAXO-study that evaluated repeated resectability, a multi-cross-sectional HRQoL substudy with 15D, EQ-5D-3L, QLQ-C30, and QLQ-CR29 questionnaires was conducted. Mean values of patients in different treatment groups were compared with age- and gender-standardized general Finnish populations. The questionnaire completion rate was 444/477 patients (93%, 1751 questionnaires). Mean HRQoL was 0.89-0.91 with the 15D, 0.85-0.87 with the EQ-5D, 68-80 with the EQ-5D-VAS, and 68-79 for global health status during curative treatment phases, with improvements in the remission phase (disease-free >18 months). In the remission phase, mean EQ-5D and 15D scores were similar to the general population. HRQoL remained stable during first- to later-line treatments, when the aim was no longer cure, and declined notably when tumour-controlling therapy was no longer meaningful. The symptom burden affecting mCRC survivors' well-being included insomnia, impotence, urinary frequency, and fatigue. Symptom burden was lower after treatment and slightly higher, though stable, through all phases of systemic therapy. HRQoL was high in curative treatment phases, further emphasizing the strategy of metastasectomy in mCRC when clinically meaningful.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a metastatic colorectal cancer
653 a metastasectomy
653 a local ablative therapy
653 a health-related quality of life
653 a QLQ-C30
653 a EQ-5D
653 a 15D
653 a QLQ-CR29
653 a systemic therapy
653 a chemotherapy
7001 a Stedt, Hanna P.u Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland.4 aut
7001 a Österlund, Emeriku Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)emeos639
7001 a Muhonen, Timou South Carelia Cent Hosp, Dept Oncol, Valto Kakelan Katu 1, Lappeenranta 53130, Finland.;Joint Municipal Author Hlth Care & Social Serv Ke, Home Care, Sairaalakatu 1, Hyvinkaa 05850, Finland.4 aut
7001 a Soveri, Leena-Maijau Joint Municipal Author Hlth Care & Social Serv Ke, Home Care, Sairaalakatu 1, Hyvinkaa 05850, Finland.;Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.4 aut
7001 a Halonen, Paiviu Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.;Helsinki Univ Hosp, Dept Oncol, Haartmaninkatu 4, Helsinki 00290, Finland.4 aut
7001 a Salminen, Tapio K.u Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.4 aut
7001 a Kononen, Juhau Cent Finland Cent Hosp, Dept Oncol, Keskussairaalantie 19, Jyvaskyla 40620, Finland.;Docrates Hosp, Docrates Canc Ctr, Saukonpaadenranta 2, Helsinki 00180, Finland.4 aut
7001 a Kallio, Raijau Oulu Univ Hosp, Dept Oncol, Kajaanintie 50, Oulu 90220, Finland.;Univ Oulu, Dept Oncol, Pentti Kaiteran Katu 1, Oulu 90570, Finland.4 aut
7001 a Algars, Annikau Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.4 aut
7001 a Heerva, Eetuu Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.4 aut
7001 a Lamminmaki, Annamarjau Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland.4 aut
7001 a Uutela, Akiu Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.4 aut
7001 a Nordin, Arnou Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.4 aut
7001 a Lehto, Juhou Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.;Tampere Univ Hosp, Palliat Care Ctr, Teiskontie 35, Tampere 33520, Finland.4 aut
7001 a Saarto, Tiinau Univ Helsinki, Dept Oncol, Haartmaninkatu 8, Helsinki 00290, Finland.;Helsinki Univ Hosp, Dept Palliat Care, Ctr Comprehens Canc, Haartmaninkatu 4, Helsinki 00290, Finland.4 aut
7001 a Sintonen, Harriu Univ Helsinki, Dept Publ Hlth, Tukholmankatu 8B, Helsinki 00290, Finland.4 aut
7001 a Kellokumpu-Lehtinen, Pirkko-Liisau Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.4 aut
7001 a Ristamaki, Raijau Turku Univ Hosp, Dept Oncol, Hameentie 11, Turku 20520, Finland.;Univ Turku, Dept Oncol, Kiinanmyllynkatu 10, Turku 20520, Finland.4 aut
7001 a Glimelius, Bengtu Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)bengglim
7001 a Isoniemi, Helenau Helsinki Univ Hosp, Dept Transplantat & Liver Surg, Abdominal Ctr, Haartmaninkatu 4, Helsinki 00290, Finland.;Univ Helsinki, Dept Surg, Haartmaninkatu 8, Helsinki 00290, Finland.4 aut
7001 a Osterlund, Piau Karolinska Institutet4 aut
7102 a Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33520, Finland.;Tampere Univ Hosp, Dept Oncol, Tays Canc Ctr, Teiskontie 35, Tampere 33520, Finland.b Kuopio Univ Hosp, Dept Oncol, Puijonlaaksontie 2, Kuopio 70210, Finland.;Univ Eastern Finland, Fac Hlth Sci, Yliopistonranta 1A, Kuopio 70210, Finland.4 org
7730 t Cancersd : MDPIg 14:7q 14:7x 2072-6694
8564 u https://doi.org/10.3390/cancers14071713y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1654886/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473585
8564 8u https://doi.org/10.3390/cancers14071713
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149311185

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