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  • Vogt, Elinor ChelsomDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway (författare)

Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Bioscientifica,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-478260
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478260URI
  • https://doi.org/10.1530/EC-22-0024DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-196823URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150575614URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63-3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Real, Francisco GómezDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway (författare)
  • Husebye, Eystein SverreDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway (författare)
  • Björnsdottir, SigridurKarolinska Institutet (författare)
  • Benediktsdottir, BryndisMedical Faculty, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland (författare)
  • Bertelsen, Randi JacobsenDepartment of Clinical Science, University of Bergen, Bergen, Norway (författare)
  • Demoly, PascalUniversity Hospital of Montpellier, IDESP, Univ Montpellier-Inserm, Montpellier, France (författare)
  • Franklin, Karl AndersUmeå universitet,Kirurgi(Swepub:umu)kafr0021 (författare)
  • de Aja Gallastegui, Leire SainzUnit of Epidemiology and Public Health, Department of Health, Basque Government, Vitoria-Gasteiz, Spain (författare)
  • González, Francisco Javier CallejasDepartment of Respiratory Medicine, Albacete University Hospital, Albacete, Spain (författare)
  • Heinrich, JoachimInstitute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia (författare)
  • Holm, MathiasOccupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (författare)
  • Jogi, Nils OscarDepartment of Clinical Science, University of Bergen, Bergen, Norway (författare)
  • Leynaert, BenedicteUniversité Paris-Saclay, Inserm U1018, Center for Epidemiology and Population Health, Integrative Respiratory Epidemiology Team, Villejuif, France (författare)
  • Lindberg, EvaUppsala universitet,Lung- allergi- och sömnforskning,Department of Medical Sciences, Respiratory, Allergy and Sleep Medicine, Uppsala University, Uppsala, Sweden(Swepub:uu)evalb (författare)
  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi,Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden(Swepub:uu)anmal535 (författare)
  • Martínez-Moratalla, JesúsPneumology Service of the General University Hospital of Albacete, Albacete, Spain; Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain (författare)
  • Mayoral, Raúl GodoyDepartment of Respiratory Medicine, Albacete University Hospital, Albacete, Spain (författare)
  • Oudin, AnnaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)anou0004 (författare)
  • Pereira-Vega, AntonioJuan Ramón Jiménez University Hospital in Huelva, Huelva, Spain (författare)
  • Semjen, Chantal RaherisonINSERM, EpiCene Team U1219, University of Bordeaux, Talence, France (författare)
  • Schlünssen, ViviDepartment of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; The National Research Center for the Working Environment, Copenhagen, Denmark (författare)
  • Triebner, KaiDepartment of Clinical Science, University of Bergen, Bergen, Norway (författare)
  • Øksnes, MarianneDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway (författare)
  • Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Endocrine Connections: Bioscientifica11:52049-3614

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