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Ambient air polluti...
Ambient air pollution and inflammation-related proteins during early childhood
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- He, Shizhen (författare)
- Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.
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- Klevebro, Susanna (författare)
- Karolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.
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- Baldanzi, Gabriel (författare)
- Uppsala universitet,Molekylär epidemiologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.
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- Pershagen, Goran (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden.
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- Lundberg, Bjorn (författare)
- Karolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.
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- Eneroth, Kristina (författare)
- SLB Anal, Environm & Hlth Adm, Stockholm, Sweden.
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- Hedman, Anna M. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Andolf, Ellika (författare)
- Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden.
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- Almqvist, Catarina (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden.
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- Bottai, Matteo (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.
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- Melen, Erik (författare)
- Karolinska Institutet,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.
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- Gruzieva, Olena (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden.;Reg Stockholm, Ctr Occupat & Environm Med, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Inst Environm Med, Nobels Vag 13,Box 210, SE-17177 Stockholm, Sweden (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Elsevier. - 0013-9351 .- 1096-0953. ; 215
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background and aim: Experimental studies show that short-term exposure to air pollution may alter cytokine concentrations. There is, however, a lack of epidemiological studies evaluating the association between long-term air pollution exposure and inflammation-related proteins in young children. Our objective was to examine whether air pollution exposure is associated with inflammation-related proteins during the first 2 years of life. Methods: In a pooled analysis of two birth cohorts from Stockholm County (n = 158), plasma levels of 92 systemic inflammation-related proteins were measured by Olink Proseek Multiplex Inflammation panel at 6 months, 1 year and 2 years of age. Time-weighted average exposure to particles with an aerodynamic diameter of <10 mu m (PM10), <2.5 mu m (PM2.5), and nitrogen dioxide (NO2) at residential addresses from birth and onwards was estimated via validated dispersion models. Stratified by sex, longitudinal cross-referenced mixed effect models were applied to estimate the overall effect of preceding air pollution exposure on combined protein levels, "inflammatory proteome", over the first 2 years of life, followed by cross-sectional protein-specific bootstrapped quantile regression analysis. Results: We identified significant longitudinal associations of inflammatory proteome during the first 2 years of life with preceding PM2.5 exposure, while consistent associations with PM10 and NO2 across ages were only observed among girls. Subsequent protein-specific analyses revealed significant associations of PM10 exposure with an increase in IFN-gamma and IL-12B in boys, and a decrease in IL-8 in girls at different percentiles of proteins levels, at age 6 months. Several inflammation-related proteins were also significantly associated with preceding PM10, PM2.5 and NO2 exposures, at ages 1 and 2 years, in a sex-specific manner. Conclusions: Ambient air pollution exposure influences inflammation-related protein levels already during early childhood. Our results also suggest age-and sex-specific differences in the impact of air pollution on children's inflammatory profiles.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Air pollution
- Particulate matter
- Inflammation
- Proteins
- Proteome
- Children
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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He, Shizhen
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Klevebro, Susann ...
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Baldanzi, Gabrie ...
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Pershagen, Goran
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Lundberg, Bjorn
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Eneroth, Kristin ...
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visa fler...
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Hedman, Anna M.
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Andolf, Ellika
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Almqvist, Catari ...
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Bottai, Matteo
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Melen, Erik
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Gruzieva, Olena
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visa färre...
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Uppsala universitet
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