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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02595naa a2200457 4500 | |
| 001 | oai:DiVA.org:uu-492149 | |
| 003 | SwePub | |
| 008 | 230102s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4921492 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-022-34636-42 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Banerjee, Sambhasan4 aut |
| 245 | 1 0 | a Amyloid fibril structure from the vascular variant of systemic AA amyloidosis |
| 264 | c 2022-11-25 | |
| 264 | 1 | b Springer Nature,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Systemic AA amyloidosis is a debilitating protein misfolding disease in humans and animals. In humans, it occurs in two variants that are called 'vascular' and 'glomerular', depending on the main amyloid deposition site in the kidneys. Using cryo electron microscopy, we here show the amyloid fibril structure underlying the vascular disease variant. Fibrils purified from the tissue of such patients are mainly left-hand twisted and contain two non-equal stacks of fibril proteins. They contrast in these properties to the fibrils from the glomerular disease variant which are right-hand twisted and consist of two structurally equal stacks of fibril proteins. Our data demonstrate that the different disease variants in systemic AA amyloidosis are associated with different fibril morphologies. | |
| 700 | 1 | a Baur, Julian4 aut |
| 700 | 1 | a Daniel, Christoph4 aut |
| 700 | 1 | a Pfeiffer, Peter Benedikt4 aut |
| 700 | 1 | a Hitzenberger, Manuel4 aut |
| 700 | 1 | a Kuhn, Lukas4 aut |
| 700 | 1 | a Wiese, Sebastian4 aut |
| 700 | 1 | a Bijzet, Johan4 aut |
| 700 | 1 | a Haupt, Christian4 aut |
| 700 | 1 | a Amann, Kerstin U4 aut |
| 700 | 1 | a Zacharias, Martin4 aut |
| 700 | 1 | a Hazenberg, Bouke P C4 aut |
| 700 | 1 | a Westermark, Gunillau Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)gunwe105 |
| 700 | 1 | a Schmidt, Matthias4 aut |
| 700 | 1 | a Fändrich, Marcus4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
| 773 | 0 | t Nature Communicationsd : Springer Natureg 13:1q 13:1x 2041-1723 |
| 856 | 4 | u https://doi.org/10.1038/s41467-022-34636-4y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1723257/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-492149 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-022-34636-4 |
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