SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-500750"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-500750" > The association bet...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005598naa a2200805 4500
001oai:DiVA.org:uu-500750
003SwePub
008230424s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5007502 URI
0247 a https://doi.org/10.1016/j.ebiom.2023.1045102 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haycock, Philip C4 aut
2451 0a The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
264 1b Elsevier,c 2023
338 a electronic2 rdacarrier
520 a BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain.METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were defined as omega 3 and omega 6 PUFAs that could be proxied by genetic polymorphisms outside the FADS region. Our study used summary genetic data on 10 PUFAs and 67 cancers, corresponding to 562,871 cases and 1,619,465 controls, collected by the Fatty Acids in Cancer Mendelian Randomization Collaboration. We estimated odds ratios (ORs) for cancer per standard deviation increase in genetically proxied PUFA exposures.FINDINGS: Genetically elevated PUFA desaturase activity was associated (P < 0.0007) with higher risk (OR [95% confidence interval]) of colorectal cancer (1.09 [1.07-1.11]), esophageal squamous cell carcinoma (1.16 [1.06-1.26]), lung cancer (1.06 [1.03-1.08]) and basal cell carcinoma (1.05 [1.02-1.07]). There was little evidence for associations with reproductive cancers (OR = 1.00 [95% CI: 0.99-1.01]; Pheterogeneity = 0.25), urinary system cancers (1.03 [0.99-1.06], Pheterogeneity = 0.51), nervous system cancers (0.99 [0.95-1.03], Pheterogeneity = 0.92) or blood cancers (1.01 [0.98-1.04], Pheterogeneity = 0.09). Findings for colorectal cancer and esophageal squamous cell carcinoma remained compatible with causality in sensitivity analyses for violations of assumptions. Secondary MR analyses highlighted higher omega 6 PUFAs (arachidonic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid) as potential mediators. PUFA biosynthesis is known to interact with aspirin, which increases risk of bleeding and inflammatory bowel disease. In a phenome-wide MR study of non-neoplastic diseases, we found that genetic lowering of PUFA desaturase activity, mimicking a hypothetical intervention to reduce cancer risk, was associated (P < 0.0006) with increased risk of inflammatory bowel disease but not bleeding.INTERPRETATION: The PUFA biosynthesis pathway may be an intervention target for prevention of colorectal cancer and esophageal squamous cell carcinoma but with potential for increased risk of inflammatory bowel disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
653 a Cancer risk
653 a Delta-5 desaturase
653 a Delta-6 desaturase
653 a Mendelian randomization
653 a Omega 3
653 a Omega 6
653 a Polyunsaturated fatty acids
7001 a Borges, Maria Carolina4 aut
7001 a Burrows, Kimberley4 aut
7001 a Lemaitre, Rozenn N4 aut
7001 a Burgess, Stephen4 aut
7001 a Khankari, Nikhil K4 aut
7001 a Tsilidis, Konstantinos K4 aut
7001 a Gaunt, Tom R4 aut
7001 a Hemani, Gibran4 aut
7001 a Zheng, Jie4 aut
7001 a Truong, Therese4 aut
7001 a Birmann, Brenda M4 aut
7001 a OMara, Tracy4 aut
7001 a Spurdle, Amanda B4 aut
7001 a Iles, Mark M4 aut
7001 a Law, Matthew H4 aut
7001 a Slager, Susan L4 aut
7001 a Saberi Hosnijeh, Fatemeh4 aut
7001 a Mariosa, Daniela4 aut
7001 a Cotterchio, Michelle4 aut
7001 a Cerhan, James R4 aut
7001 a Peters, Ulrike4 aut
7001 a Enroth, Stefan,d 1976-u Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Gyllensten4 aut0 (Swepub:uu)stenr451
7001 a Gharahkhani, Puya4 aut
7001 a Le Marchand, Loic4 aut
7001 a Williams, Ann C4 aut
7001 a Block, Robert C4 aut
7001 a Amos, Christopher I4 aut
7001 a Hung, Rayjean J4 aut
7001 a Zheng, Wei4 aut
7001 a Gunter, Marc J4 aut
7001 a Smith, George Davey4 aut
7001 a Relton, Caroline4 aut
7001 a Martin, Richard M4 aut
7102 a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org
7730 t EBioMedicined : Elsevierg 91q 91x 2352-3964
8564 u https://doi.org/10.1016/j.ebiom.2023.104510y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1752642/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-500750
8564 8u https://doi.org/10.1016/j.ebiom.2023.104510

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy