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Sökning: onr:"swepub:oai:DiVA.org:uu-502265" > Development of sens...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004614naa a2200565 4500
001oai:DiVA.org:uu-502265
003SwePub
008230524s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:151178933
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5022652 URI
0247 a https://doi.org/10.1111/all.155682 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1511789332 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tedner, Sandra G.u Karolinska Institutet4 aut
2451 0a Development of sensitization to peanut and storage proteins and relation to markers of airway and systemic inflammation :b A 24-year follow-up
264 c 2022-11-14
264 1b John Wiley & Sons,c 2023
338 a electronic2 rdacarrier
520 a BackgroundLong-time data of peanut allergy over time is sparse. We aimed to study the longitudinal development of sensitization to peanut extract and storage protein allergen molecules and associations with asthma status, airway and systemic inflammation markers.MethodsThe Swedish birth cohort BAMSE followed 4089 participants with questionnaires, clinical investigations and blood sampling between 0 and 24 years. Information on (i) background factors at 2 months, (ii) peanut allergy symptoms and IgE data (ImmunoCAP) at 4, 8, 16, and 24 years, and (iii) IgE to storage proteins, lung function data including exhaled nitric oxide (FENO) as well as systemic inflammatory markers at 24 years of age were collected.ResultsThe prevalence of peanut extract sensitization, defined as IgE ≥ 0.35 kUA/L, was 5.4%, 8.0%, 7.5%, and 6.2% at 4, 8, 16, and 24 years of age, respectively. Between 8 and 24 years of age, (33/1565) participants developed IgE-ab to peanut extract (median 1,4, range 0.7–2.6 kUA/L), and among those 85% were also sensitized to birch. Only six individuals developed sensitization to Ara h 2 (≥0.1 kUA/L) between 8 and 24 years of age, of whom three had an IgE-ab level between 0.1–0.12 kUA/L. Storage protein sensitization was associated with elevated FENO, blood eosinophils and type 2 inflammation-related systemic proteins.ConclusionSensitization to peanut extract after 4 years of age is mainly induced by birch cross-sensitization and IgE to Ara h 2 rarely emerges after eight years of age. Storage protein sensitization is associated with respiratory and systemic inflammation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a birth cohort
653 a FENO
653 a molecular allergology
653 a OLINK
653 a peanut allergy
653 a sensitization
7001 a Klevebro, Susannau Karolinska Institutet4 aut
7001 a Bergström, Annau Karolinska Institutet4 aut
7001 a Kull, Ingeru Karolinska Institutet4 aut
7001 a Andersson, Niklasu Karolinska Institutet4 aut
7001 a Borres, Magnus P.,d 1956-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Scientific, Uppsala, Sweden4 aut0 (Swepub:uu)magbo385
7001 a Ballardini, Nataliau Karolinska Institutet4 aut
7001 a Westman, Maritu Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Praktikertjanst, St Goran Asthma & Allergy Clin, Stockholm, Sweden.4 aut
7001 a Konradsen, Jon R.u Karolinska Institutet4 aut
7001 a van Hage, Marianneu Karolinska Institutet4 aut
7001 a Nilsson, Carolineu Karolinska Institutet4 aut
7001 a Melén, Eriku Karolinska Institutet4 aut
7001 a Asarnoj, Annau Karolinska Institutet4 aut
7102 a Karolinska Institutetb Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 org
7730 t Allergy. European Journal of Allergy and Clinical Immunologyd : John Wiley & Sonsg 78:2, s. 488-499q 78:2<488-499x 0105-4538x 1398-9995
8564 u https://doi.org/10.1111/all.15568y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1759078/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502265
8564 8u https://doi.org/10.1111/all.15568
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151178933

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