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Associations between environmental characteristics, high-resolution indoor microbiome, metabolome and allergic and non-allergic rhinitis symptoms for junior high school students

Fu, Xi (author)
Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.
Du, Bingqian (author)
Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.
Meng, Yi (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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Li, Yanling (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Zhu, Xunhua (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Ou, Zheyuan (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Zhang, Mei (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Wen, Huarong (author)
Baling Hlth Ctr, Dangyang 444100, Hubei, Peoples R China.
Ma'pol, Aminnuddin (author)
Minist Hlth, Gombak Dist Hlth Off, Batu Caves, Selangor Darul, Malaysia.
Hashim, Jamal Hisham (author)
Univ Selangor, Shah Alam, Selangor, Malaysia.
Hashim, Zailina (author)
Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang, Selangor, Malaysia.
Wieslander, Gunilla (author)
Uppsala universitet,Arbets- och miljömedicin
Chen, Qingmei (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Jiang, Jun (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
Wang, Juan (author)
Uppsala universitet,Arbets- och miljömedicin
Norbäck, Dan (author)
Uppsala universitet,Arbets- och miljömedicin
Xia, Yun (author)
Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.
Chen, Qingsong (author)
Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.
Sun, Yu (author)
South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.
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Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China. (creator_code:org_t)
2023
2023
English.
In: Environmental Science. - : Royal Society of Chemistry. - 2050-7887 .- 2050-7895. ; 25:4, s. 791-804
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Rhinitis is one of the most prevalent chronic diseases globally. Microbiome exposure affects the occurrence of rhinitis. However, previous studies did not differentiate allergic rhinitis (AR) and non-allergic rhinitis (NAR) in the microbial association analysis. In this study, we investigate 347 students in 8 junior high schools, Terengganu, Malaysia, who were categorized as healthy (70.9%), AR (13.8%) and NAR (15.3%) based on a self-administered questionnaire and skin prick tests of pollen, pet, mould and house dust mite allergens. Classroom microbial and metabolite exposure in vacuumed dust was characterized by PacBio long-read amplicon sequencing, quantitative PCR and LC-MS-based untargeted metabolomics. Our findings indicate a similar microbial association pattern between AR and NAR. The richness in Gammaproteobacteria was negatively associated with AR and NAR symptoms, whereas total fungal richness was positively associated with AR and NAR symptoms (p < 0.05). Brasilonema bromeliae and Aeromonas enteropelogenes were negatively associated with AR and NAR, and Deinococcus was positively associated with AR and NAR (p < 0.01). Pipecolic acid was protectively associated with AR and NAR symptoms (OR = 0.06 and 0.13, p = 0.009 and 0.045). A neural network analysis showed that B. bromeliae was co-occurring with pipecolic acid, suggesting that the protective role of this species may be mediated by releasing pipecolic acid. Indoor relative humidity and the weight of vacuum dust were associated with AR and NAR, respectively (p < 0.05), but the health effects were mediated by two protective bacterial species, Aliinostoc morphoplasticum and Ilumatobacter fluminis. Overall, our study reported a similar microbial association pattern between AR and NAR and also revealed the complex interactions between microbial species, environmental characteristics, and rhinitis symptoms.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

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art (subject category)

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