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Sökning: onr:"swepub:oai:DiVA.org:uu-502555" > Associations betwee...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008107naa a2200505 4500
001oai:DiVA.org:uu-502555
003SwePub
008230601s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5025552 URI
0247 a https://doi.org/10.1039/d2em00480a2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fu, Xiu Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.4 aut
2451 0a Associations between environmental characteristics, high-resolution indoor microbiome, metabolome and allergic and non-allergic rhinitis symptoms for junior high school students
264 c 2023
264 1b Royal Society of Chemistry,c 2023
338 a print2 rdacarrier
520 a Rhinitis is one of the most prevalent chronic diseases globally. Microbiome exposure affects the occurrence of rhinitis. However, previous studies did not differentiate allergic rhinitis (AR) and non-allergic rhinitis (NAR) in the microbial association analysis. In this study, we investigate 347 students in 8 junior high schools, Terengganu, Malaysia, who were categorized as healthy (70.9%), AR (13.8%) and NAR (15.3%) based on a self-administered questionnaire and skin prick tests of pollen, pet, mould and house dust mite allergens. Classroom microbial and metabolite exposure in vacuumed dust was characterized by PacBio long-read amplicon sequencing, quantitative PCR and LC-MS-based untargeted metabolomics. Our findings indicate a similar microbial association pattern between AR and NAR. The richness in Gammaproteobacteria was negatively associated with AR and NAR symptoms, whereas total fungal richness was positively associated with AR and NAR symptoms (p < 0.05). Brasilonema bromeliae and Aeromonas enteropelogenes were negatively associated with AR and NAR, and Deinococcus was positively associated with AR and NAR (p < 0.01). Pipecolic acid was protectively associated with AR and NAR symptoms (OR = 0.06 and 0.13, p = 0.009 and 0.045). A neural network analysis showed that B. bromeliae was co-occurring with pipecolic acid, suggesting that the protective role of this species may be mediated by releasing pipecolic acid. Indoor relative humidity and the weight of vacuum dust were associated with AR and NAR, respectively (p < 0.05), but the health effects were mediated by two protective bacterial species, Aliinostoc morphoplasticum and Ilumatobacter fluminis. Overall, our study reported a similar microbial association pattern between AR and NAR and also revealed the complex interactions between microbial species, environmental characteristics, and rhinitis symptoms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
7001 a Du, Bingqianu Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.4 aut
7001 a Meng, Yiu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Li, Yanlingu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Zhu, Xunhuau South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Ou, Zheyuanu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Zhang, Meiu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Wen, Huarongu Baling Hlth Ctr, Dangyang 444100, Hubei, Peoples R China.4 aut
7001 a Ma'pol, Aminnuddinu Minist Hlth, Gombak Dist Hlth Off, Batu Caves, Selangor Darul, Malaysia.4 aut
7001 a Hashim, Jamal Hishamu Univ Selangor, Shah Alam, Selangor, Malaysia.4 aut
7001 a Hashim, Zailinau Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, UPM, Serdang, Selangor, Malaysia.4 aut
7001 a Wieslander, Gunillau Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)guniwies
7001 a Chen, Qingmeiu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Jiang, Junu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Wang, Juanu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)juawa350
7001 a Norbäck, Danu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba
7001 a Xia, Yunu Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.4 aut
7001 a Chen, Qingsongu Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.4 aut
7001 a Sun, Yuu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7102 a Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & Ass, Sch Publ Hlth, Guangzhou 510006, Peoples R China.b South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr Or, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.4 org
7730 t Environmental Scienced : Royal Society of Chemistryg 25:4, s. 791-804q 25:4<791-804x 2050-7887x 2050-7895
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502555
8564 8u https://doi.org/10.1039/d2em00480a

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