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Sökning: onr:"swepub:oai:DiVA.org:uu-513050" > Dronedarone versus ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004291naa a2200457 4500
001oai:DiVA.org:uu-513050
003SwePub
008231017s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5130502 URI
0247 a https://doi.org/10.1002/clc.240112 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Singh, Jagmeet P.u Harvard Med Sch, Massachusetts Gen Hosp, Cardiol Div, Boston, MA USA.4 aut
2451 0a Dronedarone versus sotalol in patients with atrial fibrillation :b A systematic literature review and network meta-analysis
264 1b John Wiley & Sons,c 2023
338 a electronic2 rdacarrier
520 a BackgroundThere are limited comparative data on safety and efficacy within commonly used Vaughan-Williams (VW) class III antiarrhythmic drugs (AADs) for maintenance of sinus rhythm in adults with atrial fibrillation (AF). HypothesisWe hypothesized that dronedarone and sotalol, two commonly prescribed VW class III AADs with class II properties, have different safety and efficacy effects in patients with nonpermanent AF. MethodsA systematic literature review was conducted searching MEDLINE (R), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to June 15, 2021 (NCT05279833). Clinical trials and observational studies that evaluated safety and efficacy of dronedarone or sotalol in adults with AF were included. Bayesian random-effects network meta-analysis (NMA) was used to quantify comparative safety and efficacy. Where feasible, we performed sensitivity analyses by including only randomized controlled trials (RCTs). ResultsOf 3581 records identified through database searches, 37 unique studies (23 RCTs, 13 observational studies, and 1 nonrandomized trial) were included in the NMA. Dronedarone was associated with a statistically significantly lower risk of all-cause death versus sotalol (hazard ratio [HR] = 0.38 [95% credible interval, CrI: 0.19, 0.74]). The association was numerically similar in the sensitivity analysis (HR = 0.46 [95% CrI: 0.21, 1.02]). AF recurrence and cardiovascular death results were not significantly different between dronedarone and sotalol in all-studies and sensitivity analyses. ConclusionThe NMA findings indicate that, across all clinical trials and observational studies included, dronedarone compared with sotalol was associated with a lower risk of all-cause death, but with no difference in AF recurrence.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a antiarrhythmia agents
653 a atrial fibrillation
653 a dronedarone
653 a network meta-analysis
653 a sotalol
653 a systematic review
7001 a Blomström-Lundqvist, Carinau Uppsala universitet,Kardiologi-arrytmi,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Dept Cardiol, Örebro, Sweden.4 aut0 (Swepub:uu)carinabl
7001 a Turakhia, Mintu P.u Stanford Univ, Ctr Digital Hlth, Dept Med Cardiovasc Med, Stanford, CA USA.4 aut
7001 a Camm, A. Johnu St Georges Univ London, Cardiac Acad Grp, London, England.4 aut
7001 a Fazeli, Mir Sohailu Evidinno Outcomes Res Inc, Vancouver, BC, Canada.4 aut
7001 a Kreidieh, Bahiju Lankenau Inst Med Res, Wynnewood, PA USA.4 aut
7001 a Crotty, Christopheru Evidinno Outcomes Res Inc, Vancouver, BC, Canada.4 aut
7001 a Kowey, Peter R.u Lankenau Inst Med Res, Wynnewood, PA USA.;Thomas Jefferson Univ, Dept Med, Philadelphia, PA USA.4 aut
7102 a Harvard Med Sch, Massachusetts Gen Hosp, Cardiol Div, Boston, MA USA.b Kardiologi-arrytmi4 org
7730 t Clinical Cardiologyd : John Wiley & Sonsg 46:6, s. 589-597q 46:6<589-597x 0160-9289x 1932-8737
8564 u https://doi.org/10.1002/clc.24011y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1805429/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-513050
8564 8u https://doi.org/10.1002/clc.24011

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