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Sökning: onr:"swepub:oai:DiVA.org:uu-521510" > Spatial multiomic i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003681nam a2200385 4500
001oai:DiVA.org:uu-521510
003SwePub
008240124| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5215102 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Nezhyva, Mariyau Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Jansson group4 aut0 (Swepub:uu)marne525
2451 0a Spatial multiomic insights into acute cocaine exposure
338 a print2 rdacarrier
520 a Recent studies provide compelling evidence that cocaine-induced neurotoxicity begins within hours of a single acute cocaine exposure. Despite this, a comprehensive understanding of the molecular alterations occurring in vivo within the reward system following such an exposure has been lacking. In this study, we developed an analytical workflow that combines mass spectrometry imaging with microscale proteomics of brain regions. Here, we present a multiomic perspective on the molecular consequences of acute cocaine exposure on the principal areas of the reward system and the hippocampus. Our findings include distinct region-specific alterations in the tricarboxylic acid (TCA) cycle and lipid synthesis within the reward circuitry highlighting a significant energy depletion in mice 24 hours post-cocaine injections. Additionally, we linked widespread reductions in key neurotransmitters (GABA, glutamate, aspartate) across the reward system and calcium level modifications to changes in synaptic plasticity and mitochondria dysfunction. Mitochondrial dysfunction and energy metabolism disruption were evident through imbalances in the mitochondrial ATP production and electron transport chain components, increased susceptibility to oxidative stress, disturbances in mitochondrial transport proteins, and fluctuations in creatine and taurine levels. Among the brain regions within the reward circuitry, the prefrontal cortex (PFC) exhibited the most pronounced effects. This study not only provides a holistic overview of the intricate interplay between proteins and metabolites within the reward circuitry regions during the onset of cocaine-induced neurotoxicity but also offers novel insights into the underlying molecular mechanisms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a Biological Research on Drug Dependence
653 a Biologisk beroendeforskning
7001 a Shahen, Samah4 aut
7001 a Kabirova, Marina4 aut
7001 a Bentov-Arav, Einav4 aut
7001 a Shalev, Ori4 aut
7001 a Andrén, Per E.,c Professor,d 1957-u Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)perandre
7001 a Thornton, Claire4 aut
7001 a Yaka, Rami4 aut
7001 a Margulis, Katherine4 aut
7001 a Jansson, Erik T.,c Docent, tekn. dr.d 1984-u Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)erija780
7102 a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521510

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