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Radiotherapy-induce...
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Remes, Tiina MariaKivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
(författare)
Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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Oxford University Press,2024
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-533245
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533245URI
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https://doi.org/10.1093/neuonc/noad186DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Suo-Palosaari, Maria HelenaOulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.
(författare)
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Arikoski, Pekka MattiUniv Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland.
(författare)
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Harila, MarikaUniv Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland.
(författare)
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Koskenkorva, Paeivi Katri TuulikkiKuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.
(författare)
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Lahteenmaki, Paivi MariaTurku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
(författare)
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Lonnqvist, Tuula Riitta IrmeliUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
(författare)
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Ojaniemi, Marja KatariinaOulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.
(författare)
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Pohjasniemi, Heli
(författare)
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Puosi, RiinaUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
(författare)
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Ritari, NiinaUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
(författare)
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Sirkia, Kirsti HelenaUniv Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland.
(författare)
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Sutela, Anna KaarinaKuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.
(författare)
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Toiviainen-Salo, Sanna-MariaUniv Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland.
(författare)
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Rantala, Heikki Markku JohannesOulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.
(författare)
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Harila, ArjaUppsala universitet,Barnonkologisk och neurologisk forskning(Swepub:uu)arjha456
(författare)
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Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuro-Oncology: Oxford University Press26:2, s. 362-3731522-85171523-5866
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Remes, Tiina Mar ...
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Suo-Palosaari, M ...
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Arikoski, Pekka ...
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Harila, Marika
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Koskenkorva, Pae ...
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Lahteenmaki, Pai ...
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visa fler...
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Lonnqvist, Tuula ...
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Ojaniemi, Marja ...
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Pohjasniemi, Hel ...
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Puosi, Riina
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Ritari, Niina
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Sirkia, Kirsti H ...
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Sutela, Anna Kaa ...
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Toiviainen-Salo, ...
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Rantala, Heikki ...
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Harila, Arja
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Neuro-Oncology
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