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  • Remes, Tiina MariaKivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (författare)

Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-533245
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533245URI
  • https://doi.org/10.1093/neuonc/noad186DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Suo-Palosaari, Maria HelenaOulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland. (författare)
  • Arikoski, Pekka MattiUniv Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland. (författare)
  • Harila, MarikaUniv Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland. (författare)
  • Koskenkorva, Paeivi Katri TuulikkiKuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland. (författare)
  • Lahteenmaki, Paivi MariaTurku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland. (författare)
  • Lonnqvist, Tuula Riitta IrmeliUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (författare)
  • Ojaniemi, Marja KatariinaOulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland. (författare)
  • Pohjasniemi, Heli (författare)
  • Puosi, RiinaUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (författare)
  • Ritari, NiinaUniv Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (författare)
  • Sirkia, Kirsti HelenaUniv Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland. (författare)
  • Sutela, Anna KaarinaKuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland. (författare)
  • Toiviainen-Salo, Sanna-MariaUniv Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland. (författare)
  • Rantala, Heikki Markku JohannesOulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland. (författare)
  • Harila, ArjaUppsala universitet,Barnonkologisk och neurologisk forskning(Swepub:uu)arjha456 (författare)
  • Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neuro-Oncology: Oxford University Press26:2, s. 362-3731522-85171523-5866

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