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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005493naa a2200517 4500
001oai:DiVA.org:uu-533245
003SwePub
008240701s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5332452 URI
0247 a https://doi.org/10.1093/neuonc/noad1862 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Remes, Tiina Mariau Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
2451 0a Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
264 1b Oxford University Press,c 2024
338 a print2 rdacarrier
520 a Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a brain tumor
653 a cerebrovascular disease
653 a childhood
653 a cognitive impairment
653 a radiotherapy
7001 a Suo-Palosaari, Maria Helenau Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.4 aut
7001 a Arikoski, Pekka Mattiu Univ Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland.4 aut
7001 a Harila, Marikau Univ Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland.4 aut
7001 a Koskenkorva, Paeivi Katri Tuulikkiu Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.4 aut
7001 a Lahteenmaki, Paivi Mariau Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.4 aut
7001 a Lonnqvist, Tuula Riitta Irmeliu Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
7001 a Ojaniemi, Marja Katariinau Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.4 aut
7001 a Pohjasniemi, Heli4 aut
7001 a Puosi, Riinau Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
7001 a Ritari, Niinau Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut
7001 a Sirkia, Kirsti Helenau Univ Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland.4 aut
7001 a Sutela, Anna Kaarinau Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.4 aut
7001 a Toiviainen-Salo, Sanna-Mariau Univ Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland.4 aut
7001 a Rantala, Heikki Markku Johannesu Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.4 aut
7001 a Harila, Arjau Uppsala universitet,Barnonkologisk och neurologisk forskning4 aut0 (Swepub:uu)arjha456
7102 a Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.b Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.4 org
7730 t Neuro-Oncologyd : Oxford University Pressg 26:2, s. 362-373q 26:2<362-373x 1522-8517x 1523-5866
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533245
8564 8u https://doi.org/10.1093/neuonc/noad186

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