Search: onr:"swepub:oai:DiVA.org:uu-533245" > Radiotherapy-induce...
Fältnamn | Indikatorer | Metadata |
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000 | 05493naa a2200517 4500 | |
001 | oai:DiVA.org:uu-533245 | |
003 | SwePub | |
008 | 240701s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5332452 URI |
024 | 7 | a https://doi.org/10.1093/neuonc/noad1862 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Remes, Tiina Mariau Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut |
245 | 1 0 | a Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor |
264 | 1 | b Oxford University Press,c 2024 |
338 | a print2 rdacarrier | |
520 | a Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years. Markers of CVD and WMHs were evaluated using brain MRI, and the sum of CVD-related findings was calculated. Additionally, the associations among CVD findings, WMHs, and neuropsychological test results were analyzed.Results: Of the 68 childhood BT survivors, 54 (79%) were diagnosed with CVD and/or WMHs at a median age of 27 years. CVD and/or WMHs were associated with lower scores for verbal intelligence quotient, performance intelligence quotient (PIQ), executive function, memory, and visuospatial ability (P < .05). Additionally, survivors with microbleeds had greater impairments in the PIQ, processing speed, executive function, and visuospatial ability (P < .05). WMHs and CVD burden were associated with greater difficulties in memory function and visuospatial ability (P < .05). Small-vessel disease burden was associated with PIQ scores, processing speed, working memory, and visuospatial ability.Conclusions: The study results suggest that markers of radiotherapy-induced CVD, the additive effect of CVD markers, and risk factors of dementia are associated with cognitive impairment, which may suggest that the survivors are at a high risk of developing early-onset dementia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a brain tumor | |
653 | a cerebrovascular disease | |
653 | a childhood | |
653 | a cognitive impairment | |
653 | a radiotherapy | |
700 | 1 | a Suo-Palosaari, Maria Helenau Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.4 aut |
700 | 1 | a Arikoski, Pekka Mattiu Univ Eastern Finland, Kuopio Univ Hosp, Kuopio Pediat Res Unit, Kuopio, Finland.4 aut |
700 | 1 | a Harila, Marikau Univ Oulu, Oulu Univ Hosp, Dept Neurol, Oulu, Finland.4 aut |
700 | 1 | a Koskenkorva, Paeivi Katri Tuulikkiu Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.4 aut |
700 | 1 | a Lahteenmaki, Paivi Mariau Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.4 aut |
700 | 1 | a Lonnqvist, Tuula Riitta Irmeliu Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut |
700 | 1 | a Ojaniemi, Marja Katariinau Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.4 aut |
700 | 1 | a Pohjasniemi, Heli4 aut |
700 | 1 | a Puosi, Riinau Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut |
700 | 1 | a Ritari, Niinau Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.4 aut |
700 | 1 | a Sirkia, Kirsti Helenau Univ Helsinki, Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland.4 aut |
700 | 1 | a Sutela, Anna Kaarinau Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland.4 aut |
700 | 1 | a Toiviainen-Salo, Sanna-Mariau Univ Helsinki, Helsinki Univ Hosp, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland.4 aut |
700 | 1 | a Rantala, Heikki Markku Johannesu Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.4 aut |
700 | 1 | a Harila, Arjau Uppsala universitet,Barnonkologisk och neurologisk forskning4 aut0 (Swepub:uu)arjha456 |
710 | 2 | a Kivela City Hosp Helsinki, POB 6100, Helsinki 00099, Finland.;Oulu Univ Hosp, Dept Pediat & Adolescence, Oulu, Finland.;Univ Oulu, Res Unit Clin Med, Oulu, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.b Oulu Univ Hosp, Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol,Dept Diagnost, Oulu, Finland.4 org |
773 | 0 | t Neuro-Oncologyd : Oxford University Pressg 26:2, s. 362-373q 26:2<362-373x 1522-8517x 1523-5866 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533245 |
856 | 4 8 | u https://doi.org/10.1093/neuonc/noad186 |
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