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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03104naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-58362 | |
| 003 | SwePub | |
| 008 | 081017s2001 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1929754 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-583622 URI |
| 024 | 7 | a https://doi.org/10.1053/ejso.2000.10842 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19297542 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Holmberg, Larsu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery4 aut |
| 245 | 1 0 | a Pre-operative oestradiol levels - relation to survival in breast cancer |
| 264 | 1 | b Elsevier BV,c 2001 |
| 338 | a print2 rdacarrier | |
| 520 | a AIMS: There are clinical observations that operation during the luteal phase of the menstrual cycle (with high oestradiol levels) may positively influence prognosis in breast cancer. However, few studies have information on plasma levels of hormones pre-operatively. METHODS: We studied 774 women treated for breast cancer where plasma levels of oestradiol had been measured 1-2 days pre-operatively. Date and cause of death were ascertained from the files of the Swedish Cancer Register and 5434 person-years were observed. The endpoint was death with breast cancer as the underlying cause (n=41 and n=158 in the pre- and post-menopausal group, respectively). RESULTS: In life-table analyses, only pre-menopausal patients with oestradiol 500 pmol/l and above had a tendency (not statistically significant) for better survival. Multivariate Cox models with oestradiol modelled in continuous form yielded relative hazards (RH) close to unity in all women and in strata according to menopausal status. CONCLUSIONS: When oestradiol was analysed in categorized form, only women with the highest levels had a tendency for improved prognosis (RH around 0.7; not statistically significant). Moreover, this pattern was not apparent for pre-menopausal women. Our findings contradict the notion that the pre-operative oestradiol level is independently associated with breast cancer prognosis. | |
| 653 | a breast cancer | |
| 653 | a oestradiol | |
| 653 | a menstrual phase | |
| 653 | a survival | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Nordén, T.4 aut |
| 700 | 1 | a Lindgren, A.4 aut |
| 700 | 1 | a Wide, Leifu Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical Chemistry4 aut |
| 700 | 1 | a Degerman, M.4 aut |
| 700 | 1 | a Adami, Hans-Olovu Karolinska Institutet4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för kirurgiska vetenskaper4 org |
| 773 | 0 | t European Journal of Surgical Oncologyd : Elsevier BVg 27:2, s. 152-156q 27:2<152-156x 0748-7983x 1532-2157 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-58362 |
| 856 | 4 8 | u https://doi.org/10.1053/ejso.2000.1084 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1929754 |
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- Holmberg, Lars
- Nordén, T.
- Lindgren, A.
- Wide, Leif
- Degerman, M.
- Adami, Hans-Olov
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