The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

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Fältnamn	Indikatorer	Metadata
000		07014naa a2201621 4500
001		oai:DiVA.org:uu-74416
003		SwePub
008		060622s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:1949447
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-744162 URI
024	7	a https://doi.org/10.1126/science.11126312 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:19494472 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a El-Sayed, Najib M.4 aut
245	1 0	a The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.
264	1	b American Association for the Advancement of Science (AAAS),c 2005
338		a print2 rdacarrier
520		a Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
650	7	a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
653		a Animals
653		a Chagas Disease/drug therapy/parasitology
653		a DNA Repair
653		a DNA Replication
653		a DNA; Mitochondrial/genetics
653		a DNA; Protozoan/genetics
653		a Genes; Protozoan
653		a Genome; Protozoan
653		a Humans
653		a Meiosis
653		a Membrane Proteins/chemistry/genetics/physiology
653		a Multigene Family
653		a Protozoan Proteins/chemistry/*genetics/physiology
653		a Recombination; Genetic
653		a Repetitive Sequences; Nucleic Acid
653		a Research Support; N.I.H.; Extramural
653		a Research Support; Non-U.S. Gov't
653		a Research Support; U.S. Gov't; P.H.S.
653		a Retroelements
653		a Sequence Analysis; DNA
653		a Signal Transduction
653		a Telomere/genetics
653		a Trypanocidal Agents/pharmacology/therapeutic use
653		a Trypanosoma cruzi/chemistry/*genetics/physiology
653		a Genetics
653		a Genetik
700	1	a Myler, Peter J4 aut
700	1	a Bartholomeu, Daniella C4 aut
700	1	a Nilsson, Danielu Karolinska Institutet4 aut
700	1	a Aggarwal, Gautam4 aut
700	1	a Tran, Anh-Nhiu Karolinska Institutet4 aut
700	1	a Ghedin, Elodie4 aut
700	1	a Worthey, Elizabeth A4 aut
700	1	a Delcher, Arthur L4 aut
700	1	a Blandin, Gaêlle4 aut
700	1	a Westenberger, Scott J4 aut
700	1	a Caler, Elisabet4 aut
700	1	a Cerqueira, Gustavo C4 aut
700	1	a Branche, Carole4 aut
700	1	a Haas, Brian4 aut
700	1	a Anupama, Atashi4 aut
700	1	a Arner, Erik4 aut
700	1	a Aslund, Lenau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)lenaaslu
700	1	a Attipoe, Philip4 aut
700	1	a Bontempi, Esteban4 aut
700	1	a Bringaud, Frederic4 aut
700	1	a Burton, Peter4 aut
700	1	a Cadag, Eithon4 aut
700	1	a Campbell, David A4 aut
700	1	a Carrington, Mark4 aut
700	1	a Crabtree, Jonathan4 aut
700	1	a Darban, Hamid4 aut
700	1	a da Silveira, Jose Franco4 aut
700	1	a de Jong, Pieter4 aut
700	1	a Edwards, Kimberly4 aut
700	1	a Englund, Paul T4 aut
700	1	a Fazelina, Gholam4 aut
700	1	a Feldblyum, Tamara4 aut
700	1	a Ferella, Marcelau Karolinska Institutet4 aut
700	1	a Frasch, Alberto Carlos4 aut
700	1	a Gull, Keith4 aut
700	1	a Horn, David4 aut
700	1	a Hou, Lihua4 aut
700	1	a Huang, Yiting4 aut
700	1	a Kindlund, Ellenu Karolinska Institutet4 aut
700	1	a Klingbeil, Michele4 aut
700	1	a Kluge, Sindy4 aut
700	1	a Koo, Hean4 aut
700	1	a Lacerda, Daniela4 aut
700	1	a Levin, Mariano J4 aut
700	1	a Lorenzi, Hernan4 aut
700	1	a Louie, Tin4 aut
700	1	a Machado, Carlos Renato4 aut
700	1	a McCulloch, Richard4 aut
700	1	a McKenna, Alan4 aut
700	1	a Mizuno, Yumi4 aut
700	1	a Mottram, Jeremy C4 aut
700	1	a Nelson, Siri4 aut
700	1	a Ochaya, Stephenu Karolinska Institutet4 aut
700	1	a Osoegawa, Kazutoyo4 aut
700	1	a Pai, Grace4 aut
700	1	a Parsons, Marilyn4 aut
700	1	a Pentony, Martin4 aut
700	1	a Pettersson, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfpette
700	1	a Pop, Mihai4 aut
700	1	a Ramirez, Jose Luis4 aut
700	1	a Rinta, Joel4 aut
700	1	a Robertson, Laura4 aut
700	1	a Salzberg, Steven L4 aut
700	1	a Sanchez, Daniel O4 aut
700	1	a Seyler, Amber4 aut
700	1	a Sharma, Reuben4 aut
700	1	a Shetty, Jyoti4 aut
700	1	a Simpson, Anjana J4 aut
700	1	a Sisk, Ellen4 aut
700	1	a Tammi, Martti Tu Karolinska Institutet4 aut
700	1	a Tarleton, Rick4 aut
700	1	a Teixeira, Santuza4 aut
700	1	a Van Aken, Susan4 aut
700	1	a Vogt, Christy4 aut
700	1	a Ward, Pauline N4 aut
700	1	a Wickstead, Bill4 aut
700	1	a Wortman, Jennifer4 aut
700	1	a White, Owen4 aut
700	1	a Fraser, Claire M4 aut
700	1	a Stuart, Kenneth D4 aut
700	1	a Andersson, Björnu Karolinska Institutet4 aut
710	2	a Karolinska Institutetb Institutionen för genetik och patologi4 org
773	0	t Scienced : American Association for the Advancement of Science (AAAS)g 309:5733, s. 409-15q 309:5733<409-15x 1095-9203x 0036-8075
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16020725&dopt=Citation
856	4	u http://sgc.anlis.gob.ar/bitstream/123456789/381/1/Science%2c2005%2c309%285733%29%2c409-415..pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-74416
856	4 8	u https://doi.org/10.1126/science.1112631
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:1949447

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Av författaren/redakt...: El-Sayed, Najib ...; Myler, Peter J; Bartholomeu, Dan ...; Nilsson, Daniel; Aggarwal, Gautam; Tran, Anh-Nhi; visa fler...; Ghedin, Elodie; Worthey, Elizabe ...; Delcher, Arthur ...; Blandin, Gaêlle; Westenberger, Sc ...; Caler, Elisabet; Cerqueira, Gusta ...; Branche, Carole; Haas, Brian; Anupama, Atashi; Arner, Erik; Aslund, Lena; Attipoe, Philip; Bontempi, Esteba ...; Bringaud, Freder ...; Burton, Peter; Cadag, Eithon; Campbell, David ...; Carrington, Mark; Crabtree, Jonath ...; Darban, Hamid; da Silveira, Jos ...; de Jong, Pieter; Edwards, Kimberl ...; Englund, Paul T; Fazelina, Gholam; Feldblyum, Tamar ...; Ferella, Marcela; Frasch, Alberto ...; Gull, Keith; Horn, David; Hou, Lihua; Huang, Yiting; Kindlund, Ellen; Klingbeil, Miche ...; Kluge, Sindy; Koo, Hean; Lacerda, Daniela; Levin, Mariano J; Lorenzi, Hernan; Louie, Tin; Machado, Carlos ...; McCulloch, Richa ...; McKenna, Alan; Mizuno, Yumi; Mottram, Jeremy ...; Nelson, Siri; Ochaya, Stephen; Osoegawa, Kazuto ...; Pai, Grace; Parsons, Marilyn; Pentony, Martin; Pettersson, Ulf; Pop, Mihai; Ramirez, Jose Lu ...; Rinta, Joel; Robertson, Laura; Salzberg, Steven ...; Sanchez, Daniel ...; Seyler, Amber; Sharma, Reuben; Shetty, Jyoti; Simpson, Anjana ...; Sisk, Ellen; Tammi, Martti T; Tarleton, Rick; Teixeira, Santuz ...; Van Aken, Susan; Vogt, Christy; Ward, Pauline N; Wickstead, Bill; Wortman, Jennife ...; White, Owen; Fraser, Claire M; Stuart, Kenneth ...; Andersson, Björn; visa färre...

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