Sökning: onr:"swepub:oai:DiVA.org:uu-88274" >
Acute effects of 1-...
Acute effects of 1-octen-3-ol, a microbial volatile organic compound (MVOC)--an experimental study
-
- Wålinder, Robert (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
-
- Ernstgård, Lena (författare)
- Karolinska Institutet
-
- Norbäck, Dan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
-
visa fler...
-
- Wieslander, Gunilla (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård
-
- Johanson, Gunnar (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
-
Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 181:3, s. 141-7
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Acute effects were assessed from exposure to a common volatile compound of microbial origin, the aliphatic alcohol 1-octen 3-ol (octenol). Twenty-nine volunteers performed symptom reports, measurement of blink frequency by electromyography, measurement of the eye break-up time, vital staining of the eye, nasal lavage, acoustic rhinometry, transfer tests and dynamic spirometry. Subjects were during 2h in random order exposed to either 10mg/m(3) of octenol or clean air as control. During octenol exposure subjective ratings of smell and nasal irritation were increased together with higher nasal lavage biomarker levels of eosinophil cationic protein, myeloperoxidase and lysozyme. Also eye irritation and blinking frequency were increased together with throat irritation, mild dyspnoea after 1-h but not after 2-h, and a small decrease in vital capacity. Ratings of headache and nausea were also increased. Atopics did not have more reactions due to exposure, whereas females experienced more smell and mucosal irritation. Thus, there were both subjective and objective signs of mild mucosal irritation of eyes and airways together with symptoms of headache and nausea.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas