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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04299nam a2200445 4500 | |
| 001 | oai:DiVA.org:uu-9297 | |
| 003 | SwePub | |
| 008 | 081002s2008 | |||||||||||000 ||eng| | |
| 020 | a 9789155472931q print | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-92972 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Holdstock, Camilla,d 1975-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut |
| 245 | 1 0 | a Gastric Bypass in Morbid Obesity :b Postoperative Changes in Metabolic, Inflammatory and Gut Regulatory Peptides |
| 264 | 1 | a Uppsala :b Acta Universitatis Upsaliensis,c 2008 |
| 300 | a 59 s. | |
| 338 | a electronic2 rdacarrier | |
| 490 | 0 | a Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,x 1651-6206 ;v 380 |
| 520 | a This thesis examines the effect of surgical weight loss on gut and adipose tissue peptides involved in appetite regulation and energy homeostasis in morbidly obese humans. Roux-en-Y gastric bypass (RYGBP) is the gold standard operation used for effective long-term weight loss and improved health. The exact mechanisms for this outcome are under investigation.We measured ghrelin, a recently discovered hunger hormone, insulin, adiponectin and leptin along with anthropometry measures in 66 morbidly obese patients prior to and 6 and 12 months after RYGBP. Impressive weight loss occurred postoperatively as did alterations in the peptides. Consistent correlations were found between weight, leptin, ghrelin and insulin. The main findings were low ghrelin concentrations in obesity and an increase after RYGBP.We explored inflammatory proteins C-reactive protein (CRP), serum amyloid A and interleukin-6 before and during massive weight loss 6 and 12 months after RYGBP in morbidly obese subjects. The studied proteins declined after surgery and a correlation between CRP and homeostatic model of assessment for insulin resistance, independent of BMI, strongly linked insulin resistance and inflammation. CRP declined most in insulin-sensitive subjects.We examined the excluded stomach mucosa and vagus nerve by measuring gastrin, pepsinogen I (PGI), pancreatic polypeptide (PP) and ghrelin levels during week 1 and year after RYGBP. Ghrelin levels rose with weight loss but declined 24-hours after surgery, like PP, indicating transient vagal nerve damage. Low levels of gastrin and PGI suggest a resting mucosa.We evaluated gut peptides: peptide YY (PYY), glucaogon like peptide-1 (GLP-1), pro-neurotensin (pro-NT) and PP, in lean (young and middle-aged), obese and postoperative RYGBP subjects pre- and postprandially. RYGBP subjects had exaggerated levels of PYY and GLP-1 postprandially and higher basal proNT levels, implying a ‘satiety peptide tone’ that may contribute to the maintenance of weight loss.In summary, RYGBP results in marked weight loss and alterations in gut and adipose tissue peptides involved in appetite regulation and energy homeostasis. These postoperative peptide changes may contribute to impressive weight loss observed after RYGBP. | |
| 650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Klinisk vetenskap0 (SwePub)403032 hsv//swe |
| 650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Clinical Science0 (SwePub)403032 hsv//eng |
| 653 | a gastric bypass | |
| 653 | a morbid obesity | |
| 653 | a ghrelin | |
| 653 | a C-reactive protein | |
| 653 | a pancreatic polypeptide | |
| 653 | a peptide YY | |
| 653 | a glucagon-like peptide-1 | |
| 653 | a Medicine | |
| 653 | a Medicin | |
| 700 | 1 | a Edén Engström, Britt,c MDu Uppsala universitet,Institutionen för medicinska vetenskaper4 ths |
| 700 | 1 | a Karlsson, Anders,c Professoru Uppsala universitet,Institutionen för medicinska vetenskaper4 ths |
| 700 | 1 | a Hellström, Per,c Professoru Karolinska Institutet4 opn |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:172583/FULLTEXT01.pdfx primaryx Raw objecty fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:172583/COVER01.pdfy cover |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9297 |
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