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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03647naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-96825 | |
| 003 | SwePub | |
| 008 | 080314s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-968252 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jsbmb.2007.03.0242 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Johansson, Tobiasu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)tojoh789 |
| 245 | 1 0 | a Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells |
| 264 | 1 | b Elsevier BV,c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Activation of the NMDA receptor leads to increased intracellular Ca2+ levels ([Ca2+]i) which induces outgrowth of and morphologic changes in the neurites of the NG108-15 cell line. This effect can be blocked by antagonists for this glutamate receptor subtype (e.g. ifenprodil or AP5). We have previously shown that nanomolar concentrations of various neurosteroids modulate ifenprodil binding to the NMDA receptor. To investigate whether this interaction affects the functioning of the receptor, we studied the effect of 24 and 48 h of pregnenolone sulphate (PS) or pregnanolone sulphate (3α5βS) on glutamate-stimulated NG108-15 cells. Unexpectedly, the neurosteroids themselves had an inhibitory effect on glutamate-induced changes in neurite patterns. This effect was comparable to that of ifenprodil or AP5. Moreover, the effect of combined treatment with 3α5βS and ifenprodil on neurite morphology indicated a functional interaction between the substances. Interestingly, PS induced cell detachment over time, an effect that was further enhanced by ifenprodil. Cell detachment was also seen after 48 h of treatment with 3α5βS; however, the effect was blocked by ifenprodil and weaker than that of PS. The interaction with the NR2B-selective antagonist ifenprodil indicates that this NMDA receptor subunit may be involved in neurosteroid-induced NG108-15 cell detachment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
| 653 | a NMDA receptor | |
| 653 | a NR2B subunit | |
| 653 | a Neurosteroids | |
| 653 | a Ifenprodil | |
| 653 | a Pregnenolone sulphate (PS) | |
| 653 | a Pregnanolone sulphate (3α5βS) | |
| 653 | a NG108-15 | |
| 653 | a Neurite outgrowth | |
| 653 | a Cell adhesion | |
| 653 | a PHARMACY | |
| 653 | a FARMACI | |
| 700 | 1 | a Elfverson, Martinu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut |
| 700 | 1 | a Birgner, Carolinau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut |
| 700 | 1 | a Frändberg, Per-Andersu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut |
| 700 | 1 | a Nyberg, Fredu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)frednybe |
| 700 | 1 | a Le Grevès, Pierreu Uppsala universitet,Institutionen för neurovetenskap4 aut0 (Swepub:uu)pierlegr |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
| 773 | 0 | t Journal of Steroid Biochemistry and Molecular Biologyd : Elsevier BVg 104:3-5, s. 215-219q 104:3-5<215-219x 0960-0760x 1879-1220 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-96825 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jsbmb.2007.03.024 |
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