Search: onr:"swepub:oai:DiVA.org:uu-97760" > No evidence of asso...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05389naa a2200889 4500 | |
001 | oai:DiVA.org:uu-97760 | |
003 | SwePub | |
008 | 081114s2007 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5beea8dd-4dd2-4aa9-bbbf-d90cd0916e60 | |
009 | oai:prod.swepub.kib.ki.se:13929807 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-977602 URI |
024 | 7 | a https://doi.org/10.1038/sj.gene.63643602 DOI |
024 | 7 | a https://lup.lub.lu.se/record/6762952 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:139298072 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Abelson, Anna-Karinu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)anive102 |
245 | 1 0 | a No evidence of association between genetic variants of the PDCD1 ligands and SLE |
264 | c 2006-11-30 | |
264 | 1 | b Springer Science and Business Media LLC,c 2007 |
338 | a print2 rdacarrier | |
520 | a PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z=2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N=149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N=90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a systemic lupus erythematosus | |
653 | a genetic association | |
653 | a linkage disequilibrium | |
653 | a autoimmunity | |
653 | a PD-L1 | |
653 | a PD-L2 | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a systemic lupus erythematosus | |
653 | a genetic association | |
653 | a linkage disequilibrium | |
653 | a autoimmunity | |
653 | a PD-L1 | |
653 | a PD-L2 | |
700 | 1 | a Johansson, Cecilia M.u Uppsala universitet,Institutionen för genetik och patologi4 aut |
700 | 1 | a Kozyrev, Sergey V.u Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)sekoz957 |
700 | 1 | a Kristjansdottir, Helgau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)helkr245 |
700 | 1 | a Gunnarsson, Ivau Karolinska Institutet4 aut |
700 | 1 | a Svenungsson, Elisabetu Karolinska Institutet4 aut |
700 | 1 | a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-ajo |
700 | 1 | a Lima, Guadalupe4 aut |
700 | 1 | a Scherbarth, Hugo R4 aut |
700 | 1 | a Gamron, Susana4 aut |
700 | 1 | a Allievi, Alejandro4 aut |
700 | 1 | a Palatnik, Sergio A4 aut |
700 | 1 | a Alvarellos, Antonio4 aut |
700 | 1 | a Paira, Sergio4 aut |
700 | 1 | a Graf, Cesar4 aut |
700 | 1 | a Guillerón, Carlos4 aut |
700 | 1 | a Catoggio, Luis J4 aut |
700 | 1 | a Prigione, Carlos4 aut |
700 | 1 | a Battagliotti, Cesar G4 aut |
700 | 1 | a Berbotto, Guillermo A4 aut |
700 | 1 | a García, Mercedes A4 aut |
700 | 1 | a Perandones, Carlos E4 aut |
700 | 1 | a Truedsson, Lennart4 aut |
700 | 1 | a Steinsson, Kristjan4 aut |
700 | 1 | a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst |
700 | 1 | a Pons-Estel, Bernardo4 aut |
700 | 1 | a Alarcón-Riquelme, Marta E.u Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala |
700 | 1 | a Garcia, Ma4 aut |
700 | 1 | a Grp, Argentinean Collaborative4 aut |
710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
773 | 0 | t Genes and Immunityd : Springer Science and Business Media LLCg 8:1, s. 69-74q 8:1<69-74x 1466-4879x 1476-5470 |
856 | 4 | u https://www.nature.com/articles/6364360.pdf |
856 | 4 | u http://dx.doi.org/10.1038/sj.gene.6364360y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97760 |
856 | 4 8 | u https://doi.org/10.1038/sj.gene.6364360 |
856 | 4 8 | u https://lup.lub.lu.se/record/676295 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:13929807 |
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