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FältnamnIndikatorerMetadata
00005242naa a2200553 4500
001oai:gup.ub.gu.se/104611
003SwePub
008240528s1999 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1946241
0247 a https://gup.ub.gu.se/publication/1046112 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19462412 URI
0247 a https://doi.org/10.1046/j.1365-2796.1999.00524.x2 DOI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Andreasson, Björnu Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut
2451 0a The measurement of venous haematocrit in patients with polycythaemia vera.
264 1b Wiley,c 1999
520 a OBJECTIVE: In clinical practice, patients with polycythaemia vera (PV) are monitored by measurement of venous packed cell volume (PCV). However, whereas treatment recommendations are still based upon studies in which the results were obtained with the centrifuged microhaematocrit, currently in most instances automated blood cell counters are used to calculate PCV. In a group of patients with polycythaemia we therefore compared the results obtained by the microhaematocrit method with PCV calculated by haematology analysers. DESIGN: The study was carried out on a prospective basis. Duplicate venous blood samples were collected. The centrifuged microhaemotocrit was obtained by using an IEC Micro-MB Centrifuge. Depending on different routine methods used in the participating hospitals, the blood cell counter PCV was calculated using Coulter STKS, Bayer Technicon H2 or H3. SETTING: Patients were included from four Swedish university hospitals: Akademiska (Uppsala), Huddinge and Karolinska (Stockholm) and Sahlgrenska (Göteborg). SUBJECTS: Seventy-four patients with PV and 10 patients with secondary polycythaemia were included and a total of 150 duplicate blood samples were analysed from these subjects. RESULTS: In the 150 measurements the mean blood cell counter calculated PCV was 0.448 +/- 0.037; the mean for centrifuged microhaematocrit was 0.467 +/- 0. 037 and the difference between means was highly significant (P = 6.8 x 10-25). The means for centrifuged haematocrit and calculated PCV differed significantly in the groups of PV patients treated with phlebotomy only, hydroxyurea or radiophosphorous (P < 0.0001, respectively). In PV patients treated with alpha-interferon and in patients with secondary polycythaemia the difference in means did not reach statistical significance (P = 0.07 and P = 0.13, respectively). The groups of patients with MCV <80 fL and >/=80 fL both presented significant differences between means for calculated PCV and centrifuged haematocrit. CONCLUSIONS: If PV patients are monitored with blood cell counter calculated PCV it appears that the therapeutic goal should be to maintain the calculated PCV below 0.43, provided the local differences in calculated PCV and centrifuged haematocrit are of the same magnitude as in this study.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653 a Aged
653 a Aged
653 a 80 and over
653 a Female
653 a Hematocrit
653 a methods
653 a Humans
653 a Male
653 a Middle Aged
653 a Polycythemia Vera
653 a blood
653 a Veins
7001 a Wahlström, E4 aut
7001 a Jacobsson, Stefan,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine4 aut0 (Swepub:gu)xjacst
7001 a Björkholm, Magnusu Karolinska Institutet4 aut
7001 a Samuelsson, Ju Karolinska Institutet4 aut
7001 a Birgegård, Gunnar4 aut
7001 a Wadenvik, Hans,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xwadha
7001 a Kutti, Jacku Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xkutja
7102 a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för internmedicin4 org
7730 t Journal of internal medicined : Wileyg 246:3, s. 293-7q 246:3<293-7x 0954-6820x 1365-2796
8564 8u https://gup.ub.gu.se/publication/104611
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1946241
8564 8u https://doi.org/10.1046/j.1365-2796.1999.00524.x

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