Sökning: onr:"swepub:oai:gup.ub.gu.se/108606" > Thrombocytopenia in...
Fältnamn | Indikatorer | Metadata |
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000 | 05525naa a2200733 4500 | |
001 | oai:gup.ub.gu.se/108606 | |
003 | SwePub | |
008 | 240910s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1086062 URI |
024 | 7 | a https://doi.org/10.1093/alcalc/agp0122 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berggren, Ulf,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbeulf |
245 | 1 0 | a Thrombocytopenia in early alcohol withdrawal is associated with development of delirium tremens or seizures. |
264 | c 2009-03-16 | |
264 | 1 | b Oxford University Press (OUP),c 2009 |
520 | a AIMS: In several studies, possible risk factors/predictors for severe alcohol withdrawal syndrome (AWS), i.e. delirium tremens (DT) and/or seizures, have been investigated. We have recently observed that low blood platelet count could be such a risk factor/predictor. We therefore investigated whether such an association could be found using a large number of alcohol-dependent individuals (n = 334). METHODS: This study is a retrospectively conducted cohort study based on data from female and male patients (>20 years of age), consecutively admitted to an alcohol treatment unit. The individuals had to fulfil the discharge diagnoses alcohol dependence and alcohol withdrawal syndrome according to DSM-IV. RESULTS: During the treatment period, 3% of the patients developed DT, 2% seizures and none had co-occurrence of both conditions. Among those with DT, a higher proportion had thrombocytopenia. Those with seizures had lower blood platelet count and a higher proportion of them had thrombocytopenia. The sensitivity and specificity of thrombocytopenia for the development of DT during the treatment period was 70% and 69%, respectively. The positive predictive value (PPV) was 6% and the negative predictive value (NPV) was 99%. For the development of seizures, the figure for sensitivity was 75% and for specificity 69%. The figures for PPV and NPV were similar as those for the development of DT. CONCLUSIONS: Thrombocytopenia is more frequent in patients who develop severe AWS (DT or seizures). The findings, including the high NPV of thrombocytopenia, must be interpreted with caution due to the small number of patients who developed AWS. Further studies replicating the present finding are therefore needed before the clinical usefulness can be considered. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
653 | a Adult | |
653 | a Aged | |
653 | a Alcohol Withdrawal Delirium | |
653 | a epidemiology | |
653 | a etiology | |
653 | a Blood Cell Count | |
653 | a Central Nervous System Depressants | |
653 | a adverse effects | |
653 | a Ethanol | |
653 | a adverse effects | |
653 | a Female | |
653 | a Hemoglobins | |
653 | a metabolism | |
653 | a Humans | |
653 | a Leukocyte Count | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Retrospective Studies | |
653 | a Risk Factors | |
653 | a Seizures | |
653 | a epidemiology | |
653 | a etiology | |
653 | a Sex Factors | |
653 | a Substance Withdrawal Syndrome | |
653 | a epidemiology | |
653 | a etiology | |
653 | a Thrombocytopenia | |
653 | a epidemiology | |
653 | a etiology | |
653 | a Young Adult | |
700 | 1 | a Fahlke, Claudia,d 1964u Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology4 aut0 (Swepub:gu)xfahcl |
700 | 1 | a Berglund, Kristina,d 1969u Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology4 aut0 (Swepub:gu)xberkr |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Balldin, Jan,d 1935u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alcohol and alcoholism (Oxford, Oxfordshire)d : Oxford University Press (OUP)g 44:4, s. 382-6q 44:4<382-6x 1464-3502x 0735-0414 |
856 | 4 | u https://academic.oup.com/alcalc/article-pdf/44/4/382/688276/agp012.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/108606 |
856 | 4 8 | u https://doi.org/10.1093/alcalc/agp012 |
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