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Coupling between serotoninergic and noradrenergic neurones and gamma-motoneurones in the cat.
- Gladden, M H (författare)
- Maxwell, D J (författare)
- Sahal, A (författare)
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- 2000
- 2000
- Engelska.
- Ingår i: The Journal of physiology. - 0022-3751. ; 527 Pt 2, s. 213-23
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Noradrenaline is known to suppress transmission from group II muscle afferents when locally applied to gamma-motoneurones, and serotonin (5-HT) facilitates the transmission. The purpose of this investigation was to search for evidence of monoaminergic innervation of gamma-motoneurones. Eight gamma-motoneurones were labelled with rhodamine-dextran, and 50 micrometer thick sagittal sections of the spinal cord containing them were exposed to antibodies against dopamine beta-hydroxylase (DBH) and 5-HT. All the cells were directly and/or indirectly excited by muscle group II afferents from the muscle they innervated and/or other muscles. Appositions between monoaminergic fibres and the labelled somata and dendrites were located with three-colour confocal laser scanning microscopy by examining series of optical sections at 1 or 0.5 micrometer intervals. DBH and 5-HT varicosities formed appositions with the somata and dendrites of all the gamma-motoneurones. The mean packing densities for 5-HT (1.12 +/- 0.11 appositions per 100 micrometer(2) for somata and 0.91 +/- 0.07 per 100 micrometer(2) for dendrites) were similar to the densities of contacts reported for alpha-motoneurones. Monoaminergic varicosities in apposition to dendrites greatly outnumbered those on the somata. The density of DBH appositions was consistently lower - corresponding means were 53% and 62% of those for 5-HT on the somata and dendrites, respectively. It is concluded from an analysis of the distribution and density of varicosities in apposition to the gamma-motoneurones compared with the density in the immediate surround of the dendrites that there is indeed both a serotoninergic and noradrenergic innervation of gamma-motoneurones.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Animals
- Cats
- Cell Communication
- physiology
- Dendrites
- physiology
- Dextrans
- Dopamine beta-Hydroxylase
- metabolism
- Hindlimb
- innervation
- Image Processing
- Computer-Assisted
- Microscopy
- Confocal
- Motor Neurons
- Gamma
- physiology
- ultrastructure
- Nerve Fibers
- physiology
- Neurons
- physiology
- ultrastructure
- Norepinephrine
- physiology
- Rhodamines
- Serotonin
- physiology
- Spinal Cord
- cytology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Maxwell, D J
- Sahal, A
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