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P2RX7: Expression R...
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Backlund, L.Karolinska Institutet
(författare)
P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-08-28
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Public Library of Science (PLoS),2012
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/165228
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https://gup.ub.gu.se/publication/165228URI
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https://doi.org/10.1371/journal.pone.0043057DOI
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https://lup.lub.lu.se/record/3191448URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125350930URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124980962URI
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Ämneskategori:art swepub-publicationtype
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Context: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. Objectives: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is associated with rapid cycling in bipolar patients. Design: Gene expression analysis in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and case-case and case-control SNP/haplotype association analyses in patients. Participants: Healthy volunteers at the sleep research center, University of California, Irvine Medical Center (UCIMC), USA (n = 8) and Swedish outpatients recruited from specialized psychiatric clinics for bipolar disorder, diagnosed with bipolar disorder type 1 (n = 569; rapid cycling: n = 121) and anonymous blood donor controls (n = 1,044). Results: P2RX7 RNA levels were significantly increased during sleep deprivation in PBMCs from healthy volunteers (p = 2.3*10(-9)). The P2RX7 rs2230912_A allele was more common (OR = 2.2, p = 0.002) and the ACGTTT haplotype in P2RX7 (rs1718119 to rs1621388) containing the protective rs2230912_G allele (OR = 0.45-0.49, p = 0.003-0.005) was less common, among rapid cycling cases compared to non-rapid cycling bipolar patients and blood donor controls. Conclusions: Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder. This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lavebratt, C.Karolinska Institutet
(författare)
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Frisen, L.Karolinska Institutet
(författare)
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Nikamo, P.Karolinska Institutet
(författare)
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Sudic, D. H.
(författare)
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Träskman Bendz, LilLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)psyk-lt8
(författare)
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Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt
(författare)
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Edman, G.Karolinska Institutet
(författare)
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Vawter, M. P.
(författare)
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Osby, U.Karolinska Institutet
(författare)
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Schalling, M.Karolinska Institutet
(författare)
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Karolinska InstitutetPsykiatri, Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Plos One: Public Library of Science (PLoS)271932-6203
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Ingår i:EUROPEAN PSYCHIATRY: Public Library of Science (PLoS)270924-9338
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Backlund, L.
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Lavebratt, C.
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Frisen, L.
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Nikamo, P.
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Sudic, D. H.
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Träskman Bendz, ...
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visa fler...
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Landén, Mikael, ...
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Edman, G.
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Vawter, M. P.
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Osby, U.
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Schalling, M.
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Göteborgs universitet
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