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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07435naa a2201201 4500 | |
| 001 | oai:gup.ub.gu.se/175712 | |
| 003 | SwePub | |
| 008 | 240528s2013 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-198061 | |
| 009 | oai:prod.swepub.kib.ki.se:126344974 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1757122 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pmed.10013832 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1980612 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1263449742 URI |
| 040 | a (SwePub)gud (SwePub)uud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Vimaleswaran, K. S.4 aut |
| 245 | 1 0 | a Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts |
| 264 | c 2013-02-05 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2013 |
| 520 | a BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. METHODS AND FINDINGS: We used information from 21 adult cohorts (up to 42,024 participants) with 12 BMI-related SNPs (combined in an allelic score) to produce an instrument for BMI and four SNPs associated with 25(OH)D (combined in two allelic scores, separately for genes encoding its synthesis or metabolism) as an instrument for vitamin D. Regression estimates for the IVs (allele scores) were generated within-study and pooled by meta-analysis to generate summary effects. Associations between vitamin D scores and BMI were confirmed in the Genetic Investigation of Anthropometric Traits (GIANT) consortium (n=123,864). Each 1 kg/m(2) higher BMI was associated with 1.15% lower 25(OH)D (p=6.52×10⁻²⁷). The BMI allele score was associated both with BMI (p=6.30×10⁻⁶²) and 25(OH)D (-0.06% [95% CI -0.10 to -0.02], p=0.004) in the cohorts that underwent meta-analysis. The two vitamin D allele scores were strongly associated with 25(OH)D (p≤8.07×10⁻⁵⁷ for both scores) but not with BMI (synthesis score, p=0.88; metabolism score, p=0.08) in the meta-analysis. A 10% higher genetically instrumented BMI was associated with 4.2% lower 25(OH)D concentrations (IV ratio: -4.2 [95% CI -7.1 to -1.3], p=0.005). No association was seen for genetically instrumented 25(OH)D with BMI, a finding that was confirmed using data from the GIANT consortium (p≥0.57 for both vitamin D scores). CONCLUSIONS: On the basis of a bi-directional genetic approach that limits confounding, our study suggests that a higher BMI leads to lower 25(OH)D, while any effects of lower 25(OH)D increasing BMI are likely to be small. Population level interventions to reduce BMI are expected to decrease the prevalence of vitamin D deficiency. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a body-mass index | |
| 653 | a cardiovascular-disease risk | |
| 653 | a genome-wide association | |
| 653 | a genetic-variants | |
| 653 | a instrumental variables | |
| 653 | a d deficiency | |
| 653 | a 25-hydroxyvitamin d | |
| 653 | a d insufficiency | |
| 653 | a common obesity | |
| 653 | a prevalence | |
| 700 | 1 | a Berry, D. J.4 aut |
| 700 | 1 | a Lu, C.4 aut |
| 700 | 1 | a Tikkanen, E.4 aut |
| 700 | 1 | a Pilz, S.4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Cooper, J. D.4 aut |
| 700 | 1 | a Dastani, Z.4 aut |
| 700 | 1 | a Li, R.4 aut |
| 700 | 1 | a Houston, D. K.4 aut |
| 700 | 1 | a Wood, A. R.4 aut |
| 700 | 1 | a Michaëlsson, Karlu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich |
| 700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
| 700 | 1 | a Zgaga, L.4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a McCarthy, M. I.4 aut |
| 700 | 1 | a Dupuis, J.4 aut |
| 700 | 1 | a Kaakinen, M.4 aut |
| 700 | 1 | a Kleber, M. E.4 aut |
| 700 | 1 | a Jameson, K.4 aut |
| 700 | 1 | a Arden, N.4 aut |
| 700 | 1 | a Raitakari, O.4 aut |
| 700 | 1 | a Viikari, J.4 aut |
| 700 | 1 | a Lohman, K. K.4 aut |
| 700 | 1 | a Ferrucci, L.4 aut |
| 700 | 1 | a Melhus, Håkanu Uppsala universitet,Klinisk farmakogenomik och osteoporos4 aut0 (Swepub:uu)hakamelh |
| 700 | 1 | a Ingelsson, E.4 aut |
| 700 | 1 | a Byberg, Liisau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)liisbybe |
| 700 | 1 | a Lind, L.4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Salomaa, V.4 aut |
| 700 | 1 | a Campbell, H.4 aut |
| 700 | 1 | a Dunlop, M.4 aut |
| 700 | 1 | a Mitchell, B. D.4 aut |
| 700 | 1 | a Herzig, K. H.4 aut |
| 700 | 1 | a Pouta, A.4 aut |
| 700 | 1 | a Hartikainen, A. L.4 aut |
| 700 | 1 | a Streeten, E. A.4 aut |
| 700 | 1 | a Theodoratou, E.4 aut |
| 700 | 1 | a Jula, A.4 aut |
| 700 | 1 | a Wareham, N. J.4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Frayling, T. M.4 aut |
| 700 | 1 | a Kritchevsky, S. B.4 aut |
| 700 | 1 | a Spector, T. D.4 aut |
| 700 | 1 | a Richards, J. B.4 aut |
| 700 | 1 | a Lehtimaki, T.4 aut |
| 700 | 1 | a Ouwehand, W. H.4 aut |
| 700 | 1 | a Kraft, P.4 aut |
| 700 | 1 | a Cooper, C.4 aut |
| 700 | 1 | a Marz, W.4 aut |
| 700 | 1 | a Power, C.4 aut |
| 700 | 1 | a Loos, R. J. F.4 aut |
| 700 | 1 | a Wang, T. J.4 aut |
| 700 | 1 | a Jarvelin, M. R.4 aut |
| 700 | 1 | a Whittaker, J. C.4 aut |
| 700 | 1 | a Hingorani, A. D.4 aut |
| 700 | 1 | a Hypponen, E.4 aut |
| 710 | 2 | a Uppsala universitetb Kardiovaskulär epidemiologi4 org |
| 773 | 0 | t Plos Medicined : Public Library of Science (PLoS)g 10:2q 10:2x 1549-1676x 1549-1277 |
| 856 | 4 | u https://doi.org/10.1371/journal.pmed.1001383 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:615334/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/175712 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pmed.1001383 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198061 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126344974 |
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