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Sökning: onr:"swepub:oai:gup.ub.gu.se/176158" > Molecular Character...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004459naa a2200469 4500
001oai:gup.ub.gu.se/176158
003SwePub
008240528s2013 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1761582 URI
0247 a https://doi.org/10.1128/jcm.02971-122 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gonzales, Luciau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xgonlu
2451 0a Molecular Characterization of Enterotoxigenic Escherichia coli Isolates Recovered from Children with Diarrhea during a 4-Year Period (2007 to 2010) in Bolivia
264 1b American Society for Microbiology,c 2013
520 a Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea. This study aimed to characterize ETEC strains isolated from Bolivian children aged <5 years according to enterotoxin profile, colonization factors (CFs), suggested virulence genes, and severity of disease. A total of 299 ETEC isolates recovered from children with diarrhea and 55 ETEC isolates from children without diarrhea (controls) were isolated over a period of 4 years. Strains expressing heat-labile toxin (LT) or heat-stable toxin (ST) alone were about equally common and twice as common as ETEC producing both toxins (20%). ETEC strains expressing human ST (STh) were more common in children aged <2 years, while ETEC strains expressing LT plus STh (LT/STh) were more frequent in 2- to 5-year-old children. Severity of disease was not related to the toxin profile of the strains. CF-positive isolates were more frequently identified in diarrheal samples than in control samples (P = 0.02). The most common CFs were CFA/I and CS14. CFA/I ETEC strains were more frequent in children aged <2 years than CS1+CS3 isolates and CS14 isolates, which were more prevalent in 2- to 5-year-old children. The presence of suggested ETEC virulence genes (clyA, eatA, tia, tibC, leoA, and east-1) was not associated with disease. However, east-1 was associated with LT/STh strains (P < 0.001), eatA with STh strains (P < 0.001), and tia with LT/STh strains (P < 0.001). A minor seasonal peak of ETEC infections was identified in May during the cold-dry season and coincided with the peak of rotavirus infections; this pattern is unusual for ETEC and may be important for vaccination strategies in Bolivia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
653 a colonization factor antigens
653 a prospective cohort
653 a disease burden
653 a strains
653 a prevalence
653 a bangladesh
653 a identification
653 a infection
653 a toxins
653 a etec
7001 a Sanchez, S.4 aut
7001 a Zambrana, S.4 aut
7001 a Iniguez, V.4 aut
7001 a Wiklund, Gudrun,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xwiklg
7001 a Svennerholm, Ann-Mari,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsannx
7001 a Sjöling, Åsa,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsjoas
7102 a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org
7730 t Journal of Clinical Microbiologyd : American Society for Microbiologyg 51:4, s. 1219-1225q 51:4<1219-1225x 0095-1137x 1098-660X
8564 u https://jcm.asm.org/content/jcm/51/4/1219.full.pdf
8564 8u https://gup.ub.gu.se/publication/176158
8564 8u https://doi.org/10.1128/jcm.02971-12

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